NMDA receptors on non-dopaminergic neurons in the VTA support cocaine sensitization.

Autor: Yu Luo, Cameron H Good, Oscar Diaz-Ruiz, YaJun Zhang, Alexander F Hoffman, Lufei Shan, Serena Y Kuang, Nasir Malik, Vladimir I Chefer, Andreas C Tomac, Carl R Lupica, Cristina M Bäckman

Publikováno v: PLoS ONE, Vol 5, Iss 8, p e12141 (2010)

The initiation of behavioral sensitization to cocaine and other psychomotor stimulants is thought to reflect N-methyl-D-aspartate receptor (NMDAR)-mediated synaptic plasticity in the mesolimbic dopamine (DA) circuitry. The importance of drug induced

Externí odkaz: https://doaj.org/article/6320367ff1ae43188ebccaaaa6504c2f

(-)-Phenserine and the prevention of pre-programmed cell death and neuroinflammation in mild traumatic brain injury and Alzheimer's disease challenged mice

Autor: Daniela Lecca, Miaad Bader, David Tweedie, Alexander F. Hoffman, Yoo Jin Jung, Shin-Chang Hsueh, Barry J. Hoffer, Robert E. Becker, Chaim G. Pick, Carl R. Lupica, Nigel H. Greig

Publikováno v: Neurobiology of Disease, Vol 130, Iss , Pp 104528- (2019)

Mild traumatic brain injury (mTBI) is a risk factor for neurodegenerative disorders, such as Alzheimer's disease (AD) and Parkinson's disease (PD). TBI-derived neuropathologies are promoted by inflammatory processes: chronic microgliosis and release

Externí odkaz: https://doaj.org/article/ec8d1f8e8b1749de8bc7867330abc497

Persistent binding at dopamine transporters determines sustained psychostimulant effects

Autor: Marco Niello, Spyridon Sideromenos, Ralph Gradisch, Ronan O´Shea, Jakob Schwazer, Julian Maier, Nina Kastner, Walter Sandtner, Kathrin Jäntsch, Carl R. Lupica, Alexander F. Hoffman, Gert Lubec, Claus J. Loland, Thomas Stockner, Daniela D. Pollak, Michael H. Baumann, Harald H. Sitte

Publikováno v: Niello, M, Sideromenos, S, Gradisch, R, O'Shea, R, Schwazer, J, Maier, J, Kastner, N, Sandtner, W, Jäntsch, K, Lupica, C R, Hoffman, A F, Lubec, G, Loland, C J, Stockner, T, Pollak, D D, Baumann, M H & Sitte, H H 2023, ' Persistent binding at dopamine transporters determines sustained psychostimulant effects ', Proceedings of the National Academy of Sciences of the United States of America, vol. 120, no. 6, e2114204120 . https://doi.org/10.1073/pnas.2114204120

Psychostimulants interacting with the dopamine transporter (DAT) can be used illicitly or for the treatment of specific neuropsychiatric disorders. However, they can also pro-duce severe and persistent adverse events. Often, their pharmacological pro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df188dfc32dc6e8ac10ea0975a519aa7
https://doi.org/10.1073/pnas.2114204120

Reversing anterior insular cortex neuronal hypoexcitability attenuates compulsive behavior in adolescent rats

Autor: Kshitij S. Jadhav, Aurélien P. Bernheim, Léa Aeschlimann, Guylène Kirschmann, Isabelle Decosterd, Alexander F. Hoffman, Carl R. Lupica, Benjamin Boutrel

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America. 119(21)

Development of self-regulatory competencies during adolescence is partially dependent on normative brain maturation. Here, we report that adolescent rats as compared to adults exhibit impulsive and compulsive-like behavioral traits, the latter being

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a93fccd19bc12a1541e59939d00d2b2b
https://pubmed.ncbi.nlm.nih.gov/35584117

Stress deceleration theory – chronic adolescent stress exposure results in decelerated neurobehavioral maturation

Autor: M. Burgisser, Alexander F. Hoffman, L. Aeschlimann, C. Rosetti, Benjamin Boutrel, Kshitij S. Jadhav, Carl R. Lupica

Normative development in adolescence indicates that the prefrontal cortex is still under development thereby unable to exert efficient top-down inhibitory control on subcortical regions such as the basolateral amygdala and the nucleus accumbens. This

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::132085f8d61b9b4ea549c325063db5f0
https://doi.org/10.1101/2021.11.21.469381