Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Alexander Ewe"'
Autor:
Kristin Röhrborn, Martin Krueger, Mirjam Kalusa, Simone A. Fietz, Alexander Ewe, Achim Aigner, Michael Stumvoll, Peter Kovacs, Matthias Blüher, Imke Schamarek, Kerstin Rohde-Zimmermann
Publikováno v:
Nutrients, Vol 16, Iss 16, p 2633 (2024)
Background and aims: Saliva is essential for the proper dilution and distribution of taste molecules on the tongue. It harbors extracellular vesicles (EVs), which mediate cell–cell communication. Changes in the composition of salivary EVs may arise
Externí odkaz:
https://doaj.org/article/7d6a04e6e2274f5fb2a5424e06c04a60
Autor:
Franziska Mitrach, Maximilian Schmid, Magali Toussaint, Sladjana Dukic-Stefanovic, Winnie Deuther-Conrad, Heike Franke, Alexander Ewe, Achim Aigner, Christian Wölk, Peter Brust, Michael C. Hacker, Michaela Schulz-Siegmund
Publikováno v:
Pharmaceutics, Vol 14, Iss 2, p 326 (2022)
Convection-enhanced delivery (CED) has been introduced as a concept in cancer treatment to generate high local concentrations of anticancer therapeutics and overcome the limited diffusional distribution, e.g., in the brain. RNA interference provides
Externí odkaz:
https://doaj.org/article/a2442b8c8e9d46428d86ea4ed200a1d3
Autor:
Willi Jugel, Achim Aigner, Susanne Michen, Alexander Hagstotz, Alexander Ewe, Dietmar Appelhans, Gabriele Schackert, Achim Temme, Stefanie Tietze
Publikováno v:
Pharmaceutics, Vol 13, Iss 5, p 676 (2021)
Delivery of siRNAs for the treatment of tumors critically depends on the development of efficient nucleic acid carrier systems. The complexation of dendritic polymers (dendrimers) results in nanoparticles, called dendriplexes, that protect siRNA from
Externí odkaz:
https://doaj.org/article/fca5a2e3a35a4ba48e83b762ebacfcec
Publikováno v:
Nanomaterials, Vol 10, Iss 9, p 1809 (2020)
The delivery of small interfering RNAs (siRNA) is an efficient method for gene silencing through the induction of RNA interference (RNAi). It critically relies, however, on efficient vehicles for siRNA formulation, for transfection in vitro as well a
Externí odkaz:
https://doaj.org/article/72bf15517e7b4e0486dce299967652c9
Autor:
Susanne Przybylski, Michaela Gasch, Anne Marschner, Marcus Ebert, Alexander Ewe, Gisa Helmig, Nadja Hilger, Stephan Fricke, Susanne Rudzok, Achim Aigner, Jana Burkhardt
Publikováno v:
PLoS ONE, Vol 12, Iss 5, p e0176517 (2017)
INTRODUCTION:One of the main obstacles in the widespread application of gene therapeutic approaches is the necessity for efficient and safe transfection methods. For the introduction of small oligonucleotide gene therapeutics into a target cell, nano
Externí odkaz:
https://doaj.org/article/b941bdf6cdf24198a3b2aea67c33ba79
Autor:
Małgorzata Kubczak, Sylwia Michlewska, Michael Karimov, Alexander Ewe, Achim Aigner, Maria Bryszewska, Maksim Ionov
Publikováno v:
Nanotoxicology. 16:867-882
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::802501478e126a91f7b837a7b8d78bd1
https://doi.org/10.1080/17435390.2022.2159891
https://doi.org/10.1080/17435390.2022.2159891
Publikováno v:
Biotechnology Journal. 18
Classical two-dimensional (2D) cell culture as a drug or nanoparticle test system only poorly recapitulates in vivo conditions. Animal studies are costly, ethically controversial, and preclude large-scale testing.We established a three-dimensional (3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05417a6a00cd514cc37cd7d6e68504b1
https://doi.org/10.1002/biot.202200415
https://doi.org/10.1002/biot.202200415
Autor:
Albert Topf, Karl Sotlar, Matthias Hackl, Theo Kraus, Vera Paar, Simon Watzinger, Achim Aigner, Uta C. Hoppe, Rudin Pistulli, Moritz Mirna, Rer Nat Alexander Ewe, Bruno K. Podesser, Assoc Prof Michael Lichtenauer, Attila Kiss
Publikováno v:
Cardiovascular Research. 118:556-572
Aims Myocarditis is associated with formidable symptoms and increased risk of adverse outcomes. Current approaches mostly rely on symptomatic treatments, warranting novel concepts for clinical practice. The aim of this study was to investigate the mi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d500c4d0a9a51acd7ae0303306f18dd
https://doi.org/10.1093/cvr/cvab015
https://doi.org/10.1093/cvr/cvab015
Publikováno v:
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 161
Efficient and non-toxic DNA delivery is still a major limiting factor for non-viral gene therapy. Among the large diversity of non-viral vectors, the cationic polymer polyethylenimine (PEI) plays a prominent role in nucleic acid delivery. Since highe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::672e96a8bc63efbbb9d34f7aa3f1fd14
https://pubmed.ncbi.nlm.nih.gov/33582186
https://pubmed.ncbi.nlm.nih.gov/33582186