Comparative proteomics reveals a diagnostic signature for pulmonary head‐and‐neck cancer metastasis

Autor: Hanibal Bohnenberger, Lars Kaderali, Philipp Ströbel, Diego Yepes, Uwe Plessmann, Neekesh V Dharia, Sha Yao, Carina Heydt, Sabine Merkelbach‐Bruse, Alexander Emmert, Jonatan Hoffmann, Julius Bodemeyer, Kirsten Reuter‐Jessen, Anna‐Maria Lois, Leif Hendrik Dröge, Philipp Baumeister, Christoph Walz, Lorenz Biggemann, Roland Walter, Björn Häupl, Federico Comoglio, Kuan‐Ting Pan, Sebastian Scheich, Christof Lenz, Stefan Küffer, Felix Bremmer, Julia Kitz, Maren Sitte, Tim Beißbarth, Marc Hinterthaner, Martin Sebastian, Joachim Lotz, Hans‐Ulrich Schildhaus, Hendrik Wolff, Bernhard C Danner, Christian Brandts, Reinhard Büttner, Martin Canis, Kimberly Stegmaier, Hubert Serve, Henning Urlaub, Thomas Oellerich

Publikováno v: EMBO Molecular Medicine, Vol 10, Iss 9, Pp 1-15 (2018)

Abstract Patients with head‐and‐neck cancer can develop both lung metastasis and primary lung cancer during the course of their disease. Despite the clinical importance of discrimination, reliable diagnostic biomarkers are still lacking. Here, we

Externí odkaz: https://doaj.org/article/9e1b98ca39654a949c2bd368ebedd85e

Sarcopenia as Prognostic Factor in Lung Cancer Patients: A Systematic Review and Meta-analysis

Autor: Judith Heinz, Shekhar Saha, Ingo Kutschka, Hanibal Bohnenberger, Christian Röver, Marc Hinterthaner, Judith Buentzel, Christoph Bauer, Annalen Bleckmann, Alexander Emmert, Hassina Baraki

Publikováno v: Anticancer Research. 39:4603-4612

Background/aim Sarcopenia describes the loss of skeletal muscle mass. While this condition is associated with a high mortality in cancer patients, its influence on survival is still underestimated. Patients and methods A systematic review for article

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5ae3c04105656e0a49370171f24bc76
https://doi.org/10.21873/anticanres.13640

An Integrated Gene Expression Landscape Profiling Approach to Identify Lung Tumor Endothelial Cell Heterogeneity and Angiogenic Candidates

Autor: Albert Wolthuis, Diether Lambrechts, Xavier Sagaert, Wouter Everaerts, Junbin Qian, Yingfeng Zheng, Johan Vansteenkiste, Guy Eelen, Luc Schoonjans, Lena-Christin Conradi, Herbert Decaluwé, Alexander Emmert, Stefan Vinckier, Erik Verbeken, Paul De Leyn, Lin Lin, Shawez Khan, Birgit Weynand, Mieke Dewerchin, Lucas Treps, Liliana Sokol, Baki Topal, Bernard Thienpont, Frank J. T. Staal, Rene J. Mclaughlin, Melissa García-Caballero, Jian Wang, Federico Taverna, Peter Carmeliet, Lars Bolund, Dena Panovska, Andreas Pircher, Laure-Anne Teuwen, Yonglun Luo, Huanming Yang, Els Wauters, Joanna Kalucka, Vincent Geldhof, Francis Impens, Jermaine Goveia, Hanibal Bohnenberger, Bram Boeckx, Massimiliano Mazzone, Frederik De Smet, Vincenzo Lagani, Xuri Li, Tobias K. Karakach, Laura P.M.H. de Rooij, Katerina Rohlenova

Publikováno v: Goveia, J, Rohlenova, K, Taverna, F, Treps, L, Conradi, L-C, Pircher, A, Geldhof, V, de Rooij, L P M H, Kalucka, J, Sokol, L, García-Caballero, M, Zheng, Y, Qian, J, Teuwen, L-A, Khan, S, Boeckx, B, Wauters, E, Decaluwé, H, De Leyn, P, Vansteenkiste, J, Weynand, B, Sagaert, X, Verbeken, E, Wolthuis, A, Topal, B, Everaert, W, Bohnenberger, H, Emmert, A, Panovska, D, De Smet, F, Staal, F J T, Mclaughlin, R J, Impens, F, Lagani, V, Vinckier, S, Mazzone, M, Schoonjans, L, Dewerchin, M, Eelen, G, Karakach, T K, Yang, H, Wang, J, Bolund, L, Lin, L, Thienpont, B, Li, X, Lambrechts, D, Luo, Y & Carmeliet, P 2020, ' An Integrated Gene Expression Landscape Profiling Approach to Identify Lung Tumor Endothelial Cell Heterogeneity and Angiogenic Candidates ', Cancer Cell, vol. 37, no. 1, pp. 21-36.e13 . https://doi.org/10.1016/j.ccell.2019.12.001
Cancer Cell
Cancer Cell, 37(1), 21-36.e13. CELL PRESS

Heterogeneity of lung tumor endothelial cell (TEC) phenotypes across patients, species (human/mouse), and models (in vivo/in vitro) remains poorly inventoried at the single-cell level. We single-cell RNA (scRNA)-sequenced 56,771 endothelial cells fro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8a8902654d06bbf401b9e1610520c8a
https://doi.org/10.1016/j.ccell.2019.12.001

Association between perioperative hypothermia and patient outcomes after thoracic surgery: A single center retrospective analysis

Autor: Alexander, Emmert, Gereon, Gries, Saskia, Wand, Judith, Buentzel, Anselm, Bräuer, Michael, Quintel, Ivo F, Brandes

Publikováno v: Medicine

Supplemental Digital Content is available in the text
Hypothermia due to anaesthetic-induced impairment of thermoregulatory control and exposure to a cool environment is common in surgical patients. Peripheral vasodilation due to neuroaxial bloc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::929fd38edd4ebacc9e14f5fad4031759
https://pubmed.ncbi.nlm.nih.gov/29703025

Apigenin Reduces NF-κB and Subsequent Cytokine Production as Protective Effect in a Rodent Animal Model of Lung Ischemia-Reperfusion Injury

Autor: Tomislav Stojanovic, Bernhard C. Danner, Friedrich A. Schoendube, Alexander Emmert, Ahmad Fawad Jebran, Ioannis Bougioukas, Vassilios Didilis, R. Waldmann-Beushausen

Publikováno v: Journal of investigative surgery : the official journal of the Academy of Surgical Research. 31(2)

Lung ischemia-reperfusion injury (LIRI) can complicate lung transplantation or cardiac surgery with cardiopulmonary bypass, increasing morbidity and mortality. In LIRI, pro-inflammatory cytokines are activated, reactive oxygen species are generated a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edac0700da98ae5626122bd36ab19742
https://pubmed.ncbi.nlm.nih.gov/28340319