Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Alexander E.E. Mertens"'
Publikováno v:
Mertens, A E E, Pegtel, D M & Collard, J G 2006, ' Tiam1 takes PARt in cell polarity ', Trends in Cell Biology, vol. 16, no. 6, pp. 308-316 . https://doi.org/10.1016/j.tcb.2006.04.001
Cell polarity is an essential requirement for the proper tissue development of complex organisms. This is underscored by in vivo studies showing that loss of cell polarity contributes to the formation and progression of tumours. Evolutionary conserve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f4bd74453b32d34f463c1af9eeb4f4b
https://doi.org/10.1016/j.tcb.2006.04.001
https://doi.org/10.1016/j.tcb.2006.04.001
Autor:
Rob A. van der Kammen, John G. Collard, Alexander E.E. Mertens, Cristina Olivo, D. Michiel Pegtel, Irene H. L. Hamelers, Arnoud Sonnenberg
Publikováno v:
The Journal of Cell Biology
The Rho-like guanosine triphosphatase Rac1 regulates various signaling pathways, including integrin-mediated adhesion and migration of cells. However, the mechanisms by which integrins signal toward Rac are poorly understood. We show that the Rac-spe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2399135a33e4d4e110154b2e3dd73d61
https://doi.org/10.1083/jcb.200509172
https://doi.org/10.1083/jcb.200509172
Autor:
Alexander E.E. Mertens, Rob A. van der Kammen, Cristina Olivo, John G. Collard, Tomasz P. Rygiel
Publikováno v:
The Journal of Cell Biology
The GTPases Rac and Cdc42 play a pivotal role in the establishment of cell polarity by stimulating biogenesis of tight junctions (TJs). In this study, we show that the Rac-specific guanine nucleotide exchange factor Tiam1 (T-lymphoma invasion and met
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e00a15835a65e0ec5a48b8a99e11df65
https://doi.org/10.1083/jcb.200502129
https://doi.org/10.1083/jcb.200502129
Autor:
Kristin Strumane, Rob A. van der Kammen, Alexander E.E. Mertens, John G. Collard, Tomasz P. Rygiel
Publikováno v:
Journal of cell science. 121(Pt 8)
Tiam1 is a ubiquitously expressed activator of the small GTPase Rac. Previously, we found that Tiam1 knockout (KO) mice are resistant to DMBA-induced skin tumorigenicity, which correlated with increased apoptosis in keratinocytes of the skin epidermi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cdb5162810895fd6bfa36f63d5d5163
https://pubmed.ncbi.nlm.nih.gov/18349077
https://pubmed.ncbi.nlm.nih.gov/18349077
Autor:
Rob A. van der Kammen, Johan de Rooij, D. Michiel Pegtel, Alexander E.E. Mertens, Saskia I.J. Ellenbroek, John G. Collard
Publikováno v:
Current Biology, 17(19), 1623-1634. Cell Press
Pegtel, D M, Ellenbroek, S I J, Mertens, A E E, van der Kammen, R A, de Rooij, J & Collard, J G 2007, ' The Par-Tiam1 Complex Controls Persistent Migration by Stabilizing Microtubule-Dependent Front-Rear Polarity ', Current Biology, vol. 17, no. 19, pp. 1623-1634 . https://doi.org/10.1016/j.cub.2007.08.035
Pegtel, D M, Ellenbroek, S I J, Mertens, A E E, van der Kammen, R A, de Rooij, J & Collard, J G 2007, ' The Par-Tiam1 Complex Controls Persistent Migration by Stabilizing Microtubule-Dependent Front-Rear Polarity ', Current Biology, vol. 17, no. 19, pp. 1623-1634 . https://doi.org/10.1016/j.cub.2007.08.035
Background: The establishment and maintenance of cell polarity is crucial for many biological functions and is regulated by conserved protein complexes. The Par polarity complex consisting of Par3, Par6, and PKCζ, in conjunction with Tiam1-mediated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b9a41108f52df52ea9f34941346f718
https://research.vumc.nl/en/publications/987d7455-1545-497a-bc7d-1f87abe96ee3
https://research.vumc.nl/en/publications/987d7455-1545-497a-bc7d-1f87abe96ee3
Publikováno v:
Cell Motility in Cancer Invasion and Metastasis ISBN: 9781402040085
Rho proteins are small regulatory molecules that belong to the Ras superfamily of proteins. They act as molecular switches, shuffling between an active, GTP-bound state, and an inactive, GDP-bound state. Upon activation, they interact with a multitud
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::60d305879a711ac3c0f095736fd9f755
https://doi.org/10.1007/1-4020-4009-1_9
https://doi.org/10.1007/1-4020-4009-1_9
Publikováno v:
FEBS letters. 546(1)
The GTPases of the Rho family are molecular switches that play an important role in a wide range of cellular processes and are increasingly implicated in tumourigenesis. Unlike what was found for the Ras oncogenes in tumours, hardly any activating mu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0443e647632384ba4922460a96eb7cb
https://pubmed.ncbi.nlm.nih.gov/12829230
https://pubmed.ncbi.nlm.nih.gov/12829230
Autor:
Alexander E.E Mertens, Inge H. Briaire-de Bruijn, Manon J. Winter, Sergey V. Litvinov, Hellen A.M Rees-Bakker, Bas Nagelkerken
Publikováno v:
Experimental cell research. 285(1)
Various adhesion molecules play an important role in defining cell fate and maintaining tissue integrity. Therefore, cross-signaling between adhesion receptors should be a common phenomenon to support the orchestrated changes of cells' connections to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edec958aad68dc989d6e99103e61f7f5
https://pubmed.ncbi.nlm.nih.gov/12681286
https://pubmed.ncbi.nlm.nih.gov/12681286