Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Alexander E. Pashenko"'
Autor:
Oleksandr V. Oksiuta, Alexander E. Pashenko, Radomyr V. Smalii, Dmitry M. Volochnyuk, Serhii V. Ryabukhin
Publikováno v:
Журнал органічної та фармацевтичної хімії, Vol 21, Iss 1, Pp 3-19 (2023)
Aim. DNA-encoded libraries technologies (DELT) are gradually becoming an important part of standard drug discovery toolbox. DELT is looking to find its place between classic low-molecular-weight drug candidates on the one hand, and high-molecular-wei
Externí odkaz:
https://doaj.org/article/b8a205e657b04a6b81a395f328cea39f
Autor:
Alexey V. Rayevsky, Andrii S. Poturai, Iryna O. Kravets, Alexander E. Pashenko, Tatiana A. Borisova, Ganna M. Tolstanova, Dmitriy M. Volochnyuk, Petro O. Borysko, Olga B. Vadzyuk, Diana O. Alieksieieva, Yuliana Zabolotna, Olga Klimchuk, Dragos Horvath, Gilles Marcou, Sergey V. Ryabukhin, Alexandre Varnek
Publikováno v:
Molecules, Vol 27, Iss 17, p 5400 (2022)
New models for ACE2 receptor binding, based on QSAR and docking algorithms were developed, using XRD structural data and ChEMBL 26 database hits as training sets. The selectivity of the potential ACE2-binding ligands towards Neprilysin (NEP) and ACE
Externí odkaz:
https://doaj.org/article/178e51ad7468417082ac12b519f61623
Autor:
Iryna O. Kravets, Dmytro V. Dudenko, Alexander E. Pashenko, Tatiana A. Borisova, Ganna M. Tolstanova, Sergey V. Ryabukhin, Dmitriy M. Volochnyuk
Publikováno v:
Molecules, Vol 26, Iss 24, p 7584 (2021)
We elaborate new models for ACE and ACE2 receptors with an excellent prediction power compared to previous models. We propose promising workflows for working with huge compound collections, thereby enabling us to discover optimized protocols for virt
Externí odkaz:
https://doaj.org/article/f0b2a9e97b9841dab8165dd41be824ac
Autor:
Isaac F. Yu, Jenna L. Manske, Alejandro Diéguez-Vázquez, Antonio Misale, Alexander E. Pashenko, Pavel K. Mykhailiuk, Sergey V. Ryabukhin, Dmitriy M. Volochnyuk, John F. Hartwig
Publikováno v:
Nature Chemistry. 15:685-693
Autor:
Alexander E. Pashenko, Alexandr Gaidai, Nazar Hryhoriev, Olesia Volovenko, Igor Levandovskiy, Olga Maksymenko, Dmitriy M. Volochnyuk, Sergey V. Ryabukhin
Publikováno v:
Organic Process Research & Development. 27:477-487
Autor:
Dmitriy M. Volochnyuk, Denys A. Kvasha, Alexander B. Rozhenko, Alexander E. Pashenko, Mykola O. Pashko, Pavel S. Nosik, Sergiy Suikov, Andrii S. Poturai, Sergey V. Ryabukhin, Yurii L. Yagupolskii
Publikováno v:
European Journal of Organic Chemistry. 2021:6604-6615
Autor:
Eugeniy N. Ostapchuk, Alexander E. Pashenko, Sergey V. Ryabukhin, Eduard B. Rusanov, Yaroslav O. Chuchvera, Andriy I. Frolov, Dmitriy M. Volochnyuk
Publikováno v:
The Journal of Organic Chemistry. 86:7333-7346
The convenient and scalable preparative approach for the two-step α-methylation of ketones is described. The optimized protocols for regioselective preparation of enaminones with further diastereoselective and functional groups tolerant hydrogenatio
Autor:
Andrey A. Fokin, Olga K. Reshetylova, Vladyslav V. Bakhonsky, Alexander E. Pashenko, Alena Kivernik, Tatyana S. Zhuk, Jonathan Becker, Jeremy E. P. Dahl, Robert M. K. Carlson, Peter R. Schreiner
Publikováno v:
Organic letters. 24(27)
We present a strategy for the skeletal editing of diamondoid structures to selectively displace methylene for heteroatom moieties in the carbon framework. This constitutes a synthetic approach to doping diamond-like structures with electron donor dop
Autor:
Bifu Liu, Pavel A. Gunchenko, Alexander E. Pashenko, Tatyana S. Zhuk, Vladyslav V. Bakhonsky, Hongyan Chen, Jing Li, Andrey A. Fokin
Publikováno v:
Molecular Catalysis. 447:72-79
The potential of highly polar trifluoroacetic acid as a media for the metal-free aerobic oxidations propagated by phthalimide N-oxyl- (PINO) radical was demonstrated experimentally utilizing N-hydroxyphthalimide (NHPI) as a catalyst and HNO3 or NaNO2
Autor:
Lesya V. Chernish, Jonathan Becker, Peter R. Schreiner, Andrey A. Fokin, Alexander E. Pashenko, Pavel A. Gunchenko, Tatyana S. Zhuk, A. O. Kushko, Vladyslav V. Bakhonsky, Raffael C. Wende
Publikováno v:
Synthesis. 49:2003-2008
The reaction of 1-hydroxydiamantane with elemental bromine leads to consecutive cage opening and re-closure, thereby providing a straightforward approach to the class of previously unknown 1,2-disubstituted diamondoid derivatives. Functional group ex