Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Alexander E. Linsalata"'
Autor:
Katelyn M. Green, M. Rebecca Glineburg, Michael G. Kearse, Brittany N. Flores, Alexander E. Linsalata, Stephen J. Fedak, Aaron C. Goldstrohm, Sami J. Barmada, Peter K. Todd
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
A nucleotide repeat expansion in C9orf72 is a common genetic cause of neurodegenerative disorders. Here, the authors provide insight into the molecular mechanism by which this repeat undergoes Repeat-Associated Non-AUG (RAN) translation, implicating
Externí odkaz:
https://doaj.org/article/265548349b414438ad9f9384c10a2220
Autor:
Amy Krans, Alexander E. Linsalata, Stephen J. Fedak, Peter K. Todd, M. R. Glineburg, Sam Natla, Hilary C. Archbold, Ahmed M. Malik, Katelyn M. Green, Brittany N. Flores, Fang He, Sami J. Barmada
Publikováno v:
EMBO Rep
A CGG trinucleotide repeat expansion in the 5' UTR of FMR1 causes the neurodegenerative disorder Fragile X-associated tremor/ataxia syndrome (FXTAS). This repeat supports a non-canonical mode of protein synthesis known as repeat-associated, non-AUG (
Autor:
Stephen J. Fedak, Aaron C. Goldstrohm, Brittany N. Flores, Katelyn M. Green, Peter K. Todd, Michael G. Kearse, Sami J. Barmada, M. Rebecca Glineburg, Alexander E. Linsalata
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Nature Communications
Nature Communications
Repeat-associated non-AUG (RAN) translation allows for unconventional initiation at disease-causing repeat expansions. As RAN translation contributes to pathogenesis in multiple neurodegenerative disorders, determining its mechanistic underpinnings m
Publikováno v:
Journal of Comparative Neurology. 522:921-936
The regulation of synaptic strength at γ-aminobutyric acid (GABA)-ergic synapses is dependent on the dynamic capture, retention, and modulation of GABA A-type receptors by cytoplasmic proteins at GABAergic postsynaptic sites. How these proteins are
Nucleotide-repeat expansions underlie a heterogeneous group of neurodegenerative and neuromuscular disorders for which there are currently no effective therapies. Recently, it was discovered that such repetitive RNA motifs can support translation ini
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07368b3b312a4805b241b76d5db58a54
https://europepmc.org/articles/PMC5003667/
https://europepmc.org/articles/PMC5003667/
Autor:
Amy Krans, Caitlin M. Rodriguez, Michael G. Kearse, Peter K. Todd, Alexander E. Linsalata, Aaron C. Goldstrohm, Katelyn M. Green
Repeat-associated non-AUG (RAN) translation produces toxic polypeptides from nucleotide repeat expansions in the absence of an AUG start codon and contributes to neurodegenerative disorders such as ALS and fragile X-associated tremor/ataxia syndrome.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b05a96884aeb4134ecd7f91d9807617e
https://europepmc.org/articles/PMC4854189/
https://europepmc.org/articles/PMC4854189/
Publikováno v:
The Journal of comparative neurology. 522(4)
The regulation of synaptic strength at γ-aminobutyric acid (GABA)-ergic synapses is dependent on the dynamic capture, retention, and modulation of GABA A-type receptors by cytoplasmic proteins at GABAergic postsynaptic sites. How these proteins are