Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Alexander E. Kabakov"'
Publikováno v:
Cells, Vol 10, Iss 12, p 3446 (2021)
The high frequency of breast cancer worldwide and the high mortality among women with this malignancy are a serious challenge for modern medicine. A deeper understanding of the mechanisms of carcinogenesis and emergence of metastatic, therapy-resista
Externí odkaz:
https://doaj.org/article/c5064f22a7994820af339e854fab0425
Autor:
Alexander E. Kabakov, Anna O. Yakimova
Publikováno v:
Cancers, Vol 13, Iss 5, p 1102 (2021)
Within aggressive malignancies, there usually are the “hypoxic zones”—poorly vascularized regions where tumor cells undergo oxygen deficiency through inadequate blood supply. Besides, hypoxia may arise in tumors as a result of antiangiogenic th
Externí odkaz:
https://doaj.org/article/f0411d994f574c8ab1492d9def1dfb2a
Autor:
Vladimir A Kudryavtsev, Anna V Khokhlova, Vera A Mosina, Elena I Selivanova, Alexander E Kabakov
Publikováno v:
PLoS ONE, Vol 12, Iss 3, p e0173640 (2017)
We studied a role of the inducible heat shock protein 70 (Hsp70) in cellular response to radiosensitizing treatments with inhibitors of the heat shock protein 90 (Hsp90) chaperone activity. Cell lines derived from solid tumors of different origin wer
Externí odkaz:
https://doaj.org/article/c69150df6b7942b0bfc8b62f7c395350
Autor:
Anna O Yakimova, Alexander E Kabakov
Publikováno v:
Cancers
Cancers, Vol 13, Iss 1102, p 1102 (2021)
Cancers, Vol 13, Iss 1102, p 1102 (2021)
Simple Summary Some regions of aggressive malignancies experience hypoxia due to inadequate blood supply. Cancer cells adapting to hypoxic conditions somehow become more resistant to radiation exposure and this decreases the efficacy of radiotherapy
Publikováno v:
Cells
Cells, Vol 9, Iss 892, p 892 (2020)
Cells, Vol 9, Iss 892, p 892 (2020)
Cancer stem cells (CSCs) are a great challenge in the fight against cancer because these self-renewing tumorigenic cell fractions are thought to be responsible for metastasis dissemination and cases of tumor recurrence. In comparison with non-stem ca
Publikováno v:
"Radiation and Risk" Bulletin of the National Radiation and Epidemiological Registry. 27:62-75
Publikováno v:
Proceedings for Annual Meeting of The Japanese Pharmacological Society. :PO3-7
Publikováno v:
Methods in Molecular Biology ISBN: 9781493974764
Heat shock proteins are well-known protectors from cell death. Cell death (in particular, apoptosis and necrosis) is accompanied by certain hallmarks manifested as specific alterations in cellular membranes, cytoplasm, nucleus, and mitochondria. Some
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::07b39d8658bbc8a0c4bdf6e3d56a2e7e
https://doi.org/10.1007/978-1-4939-7477-1_9
https://doi.org/10.1007/978-1-4939-7477-1_9
Autor:
Vera A. Mosina, Elena I. Selivanova, Vladimir A. Kudryavtsev, Anna V. Khokhlova, Alexander E. Kabakov
Publikováno v:
PLoS ONE, Vol 12, Iss 3, p e0173640 (2017)
PLoS ONE
PLoS ONE
We studied a role of the inducible heat shock protein 70 (Hsp70) in cellular response to radiosensitizing treatments with inhibitors of the heat shock protein 90 (Hsp90) chaperone activity. Cell lines derived from solid tumors of different origin wer
Publikováno v:
Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry. 6:61-67
Effects of inhibitors of the heat shock protein 90 (HSP90) chaperone activity and inhibitors of the heat shock protein (HSP) expression on sensitivity of HeLa tumor cells to hyperthermia were studied. It was found that nanomolar concentrations of inh