Výsledky vyhledávání - "Alexander E. Felice"

Novel leukocyte-depleted platelet-rich plasma-based skin equivalent as an in vitro model of chronic wounds: a preliminary study

Autor: Alexander E. Felice, Kevin Schembri, Elisa Seria, Gabriella Grech, Sarah Samut Tagliaferro, George Galea, Joseph Borg

Publikováno v: BMC Molecular and Cell Biology
BMC Molecular and Cell Biology, Vol 22, Iss 1, Pp 1-13 (2021)

Background: Chronic leg ulcerations are associated with Haemoglobin disorders, Type2 Diabetes Mellitus, and long-term venous insufficiency, where poor perfusion and altered metabolism develop into a chronic inflammation that impairs wound closure. Sk

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a053d7035e2dc2703f804d681dccb4fc
https://pubmed.ncbi.nlm.nih.gov/33971814

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Genetic Heterogeneity of KLF1, a Master Regulator of Erythropoiesis, Revealed an Autosomal Recessive Ψβ-Thalassemia and a Very Strong Promoter In Vivo

Autor: Alexander E. Felice, Laura Grech, Carmen Attard, Ruth Galdies, Sjaak Philipsen, Christian Scerri, Joseph Borg

Publikováno v: Blood. 136:7-7

The Erythroid Kruppel-like Factor 1 or KLF1 is a transcription factor that functioned in the early stage genetic programming of erythroid progenitors to promote physiological γ to β globin gene switching. Indeed, we showed that a truncation mutatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7b66e7d87ec08b117e36950196305753
https://doi.org/10.1182/blood-2020-143018

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A Functional Single Nucleotide Polymorphism in the Aγ Globin Gene Promoter Affects Globin Chain Synthesis

Autor: Alexander E. Felice, Elena Spiteri, Laura Grech, Joseph Borg

Publikováno v: Blood. 136:20-20

Beta Thalassemia and related hemoglobinopathies (such as sickle cell disease), are usually characterized by high levels of HbF since this compensates for the lack of, or abnormal HbA that is expressed in vivo. Further insight on how the hemoglobin sw

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dd28cb95bb1cdbba29f49057831834be
https://doi.org/10.1182/blood-2020-143116

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ComparativeIn VivoExpression of β+-Thalassemia Alleles

Autor: S O Zarroag, C A Scerri, Marina Kleanthous, A Cao, Andriani Kyrri, Michael Angastiniotis, Alexander E. Felice, M M Marwan, Panos Ioannou, E. Kalogirou

Publikováno v: Europe PubMed Central

Double heterozygotes who inherit one abnormal though stable beta-globin variant in association with a molecularly identified beta(+)-thalassaemia allele provide unique opportunities to quantify the in vivo expression of particular beta(+)-thalassemia

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42b9968676e2ae9ba5ad82cb7715b5b1
https://doi.org/10.3109/03630269909005702

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Genomic variation in the MAP3K5 gene is associated with β-thalassemia disease severity and hydroxyurea treatment efficacy

Autor: Eleana F. Stavrou, Arsinoi Paizi, Sjaak Philipsen, Sonja Pavlovic, Branka Zukic, Alexandra Kourakli, Marianthi Georgitsi, Marina Bartsakoulia, Olga Giannakopoulou, Emily Giannopoulou, Maja Stojiljkovic-Petrovic, Christina Tafrali, Alexander E. Felice, Joseph Borg, George P. Patrinos, Milena Radmilovic, Adamantia Papachatzopoulou, Polyxeni Lambropoulou, Konstantinos Poulas

Publikováno v: Pharmacogenomics, 14(5), 469-483. Future Medicine Ltd.
Pharmacogenomics
Pharmacogenomics; Vol 14

Aim: In this study we explored the association between genetic variations in MAP3K5 and PDE7B genes, residing on chromosome 6q23, and disease severity in β-hemoglobinopathy patients, as well as the association between these variants with response to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5b16a9d90fb82a1b84b4b20d1043eb1
https://pubmed.ncbi.nlm.nih.gov/23556445

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Characterization and locus assignment of two alpha-globin variants present in the Maltese population: Hb St. Luke's [alpha95(G2)Pro--Arg] and Hb Setif [alpha94(G1)Asp--Tyr]

Autor: Ruth Galdies, S. Bezzina Wettinger, Alexander E. Felice, Christian Scerri

Publikováno v: Europe PubMed Central

Two types of alpha-globin variants were found in 0.2% of a large number of newborn from Malta. The two hemoglobins were identified from tryptic maps on a Vydac C18 column and by alpha-globin gene sequencing as Hb St. Luke's (isoelectric point = 7.18+

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9285bef51840b5815ba30e98415f3add
https://pubmed.ncbi.nlm.nih.gov/10335982

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Does Quantitative Heterogeneity of Human Fetal Hemoglobin (Hb F) Reveal Friends or Foes of KLF1 in Globin Gene Switching ?

Autor: George P. Patrinos, Joseph A. Borg, Ruth Galdies, Sjaak Philipsen, Godfrey Grech, Wilma Cassar, Christian Scerri, Alexander E. Felice

Publikováno v: Blood. 118:1092-1092

Abstract 1092 The chemical heterogeneity of fetal hemoglobin (Hb F) due to variable ratios of the Gγ and Aγ globin subunits reflects genetic complexity because of common dimorphisms such as Hb F Sardegna (or Aγ75(E19) Ile>Thr; also known as AγT)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::21dfcb32f6038b171b57f3f14519a735
https://doi.org/10.1182/blood.v118.21.1092.1092

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KLF1 Dependent Pathways In Developmental Globin Gene Switching

Autor: Alexander E. Felice

Publikováno v: Blood. 116:5162-5162

Abstract 5162 We provide additional data on members of the family from Malta with Hereditary Persistence of Fetal Hemoglobin (HPFH) due to KLF1 haplo-insufficiency. The data indicated a possible role of additional loci in the pathway of globin gene c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bac23a4feba35fb80b7b54d5add2b183
https://doi.org/10.1182/blood.v116.21.5162.5162

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