Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Alexander E. Davies"'
Autor:
Alexander E. Davies, John G. Albeck
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 6 (2018)
Intra-tumor cellular heterogeneity is a major challenge in cancer therapy. Tumors are composed of multiple phenotypic subpopulations that vary in their ability to initiate metastatic tumors and in their sensitivity to chemotherapy. In many cases, cel
Externí odkaz:
https://doaj.org/article/e8d45dddb46d48f1aaf2443893ca168c
Publikováno v:
Methods in Molecular Biology ISBN: 9781071630075
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0c6161d342162640a63a3f73beffd26d
https://doi.org/10.1007/978-1-0716-3008-2_13
https://doi.org/10.1007/978-1-0716-3008-2_13
Autor:
Daniel Zheng, Sam Blackwell, Charles Blundell, Demis Hassabis, Marc Lackenby, Alexander E. Davies, Richard Tanburn, Geordie Williamson, Nenad Tomasev, András Juhász, Lars Buesing, Pushmeet Kohli, Petar Veličković, Peter W. Battaglia
Publikováno v:
Nature
The practice of mathematics involves discovering patterns and using these to formulate and prove conjectures, resulting in theorems. Since the 1960s, mathematicians have used computers to assist in the discovery of patterns and formulation of conject
Autor:
Haylie R. Helms, Alexander E. Davies, Rebekka Duhen, Joshua M. Moreau, Ellen M. Langer, Luiz E. Bertassoni
Publikováno v:
Cancer Research. 83:LB161-LB161
The specific communication of multiple cell types in the tumor microenvironment plays a critical role in cancer progression. Current engineering methods have failed to adequately replicate the complexities of the tumor microenvironment (TME). In part
Autor:
Camille A. McAloney, Rawan Makkawi, Matthew V. Cannon, Amy C. Gross, Maren Cam, Emily Franz, Tatyana A. Vetter, Alexander E. Davies, Ryan D. Roberts
Publikováno v:
Cancer Research. 83:2533-2533
We sought to identify dependencies of slow growing, chemo-resistant osteosarcoma cells that anchor in the metastatic niche. These dependencies yield insight into what allows early cells to survive in the hostile lung environment, as well as potential
Publikováno v:
Veterinary and comparative oncology, vol 19, iss 3
Vet Comp Oncol
Vet Comp Oncol
Histone demethylases are overexpressed or display altered activity in numerous human cancers leading to alterations in cell cycle dynamics, DNA repair kinetics, and therapeutic resistance. Consequently, therapeutic targeting of histone demethylases h
Autor:
Alexander E. Davies, M.R. Watts, Justin T. Breitbach, Joelle M. Fenger, Savannah J. Tobin, Darian S. Louke
Publikováno v:
Veterinary and Comparative Oncology
Verdinexor (KPT‐335) is a novel orally bioavailable selective inhibitor of nuclear export (SINE) compound that inhibits the function of the nuclear export protein Exportin 1 (XPO1/CRM1). In the present study, we sought to characterize the expressio
Autor:
Vijaya Bharti, Reese Watkins, Amrendra Kumar, Rebecca L. Shattuck-Brandt, Alexis Mossing, Arjun Mittra, Chengli Shen, Allan Tsung, Alexander E. Davies, Walter Hanel, John C. Reneau, Catherine Chung, Gina M. Sizemore, Ann Richmond, Vivian L. Weiss, Anna E. Vilgelm
Publikováno v:
Cell Rep
Cancer therapies trigger diverse cellular responses, ranging from apoptotic death to acquisition of persistent therapy-refractory states such as senescence. Tipping the balance toward apoptosis could improve treatment outcomes regardless of therapeut
Autor:
Savannah J Tobin, Abhineet R. Ram, Gerald Quon, Alexander E. Davies, Taryn E. Gillies, Mina J. Bissell, Celina E. Juliano, Stefan Siebert, John G. Albeck, Michael Pargett
The EGFR/Ras/ERK signalling pathway is a driver of cancer cell proliferation and metastasis in tumours that exhibit high cell-to-cell heterogeneity. While the signalling activity of this pathway is frequently amplified in tumours, it is not understoo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21e5059074ff6ff964795db4a3753683
https://doi.org/10.1101/466656
https://doi.org/10.1101/466656
Publikováno v:
Essays in biochemistry, vol 62, iss 4
Communication between and within cells is essential for multicellular life. While intracellular signal transduction pathways are often specified in molecular terms, the information content they transmit remains poorly defined. Here, we review researc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59f3280b0a6190b53b7977bed4a84171
https://escholarship.org/uc/item/1732t2pp
https://escholarship.org/uc/item/1732t2pp