Cryo-EM structure of the fully-loaded asymmetric anthrax lethal toxin in its heptameric pre-pore state.

Autor: Claudia Antoni, Dennis Quentin, Alexander E Lang, Klaus Aktories, Christos Gatsogiannis, Stefan Raunser

Publikováno v: PLoS Pathogens, Vol 16, Iss 8, p e1008530 (2020)

Anthrax toxin is the major virulence factor secreted by Bacillus anthracis, causing high mortality in humans and other mammals. It consists of a membrane translocase, known as protective antigen (PA), that catalyzes the unfolding of its cytotoxic sub

Externí odkaz: https://doaj.org/article/a52dd63056ea47a8930898189a56eab0

Inhibition of Arp2/3 Complex after ADP-Ribosylation of Arp2 by Binary Clostridioides Toxins

Autor: Carsten Schwan, Alexander E. Lang, Andreas Schlosser, Setsuko Fujita-Becker, Abdulatif AlHaj, Rasmus R. Schröder, Jan Faix, Klaus Aktories, Hans Georg Mannherz

Publikováno v: Cells; Volume 11; Issue 22; Pages: 3661

Clostridioides bacteria are responsible for life threatening infections. Here, we show that in addition to actin, the binary toxins CDT, C2I, and Iota from Clostridioides difficile, botulinum, and perfrigens, respectively, ADP-ribosylate the actin-re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6391d981e3e3e3f94da4c2b6093e6859

Defined stereoisomers of 2″-amino NAD+ and their activity against human sirtuins and a bacterial (ADP-ribosyl) transferase

Autor: Sarah Zähringer, Tobias Rumpf, Jelena Melesina, Alexander E. Lang, Klaus Aktories, Wolfgang Sippl, Manfred Jung, Gerd K. Wagner

Publikováno v: Zähringer, S, Rumpf, T, Melesina, J, Lang, A E, Aktories, K, Sippl, W, Jung, M & Wagner, G K 2022, ' Defined stereoisomers of 2″-amino NAD+ and their activity against human sirtuins and a bacterial (ADP-ribosyl) transferase ', Bioorganic & Medicinal Chemistry, vol. 68, 116875 . https://doi.org/10.1016/j.bmc.2022.116875

Nicotinamide adenine dinucleotide (NAD+) is an important biomolecule with essential roles at the intersection of energy metabolism, epigenetic regulation and cell signalling. Synthetic analogues of NAD+ are therefore of great interest as chemical too

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1d0f36f7306d1e94a87786fe273540c
https://doi.org/10.1016/j.bmc.2022.116875

Rho-modifying bacterial protein toxins from Photorhabdus species

Autor: Klaus Aktories, Alexander E. Lang, Thomas Jank

Publikováno v: Toxicon. 116:17-22

Photorhabdus bacteria live in symbiosis with entomopathogenic nematodes. The nematodes invade insect larvae, where they release the bacteria, which then produce toxins to kill the insects. Recently, the molecular mechanisms of some toxins from Photor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d567ef8416b02bd70dac0ef0b99b692
https://doi.org/10.1016/j.toxicon.2015.05.017

Mechanism of Tc toxin action revealed in molecular detail

Autor: Stefan Raunser, Ingrid R. Vetter, Dominic Meusch, Rouslan G. Efremov, Oliver Hofnagel, Christos Gatsogiannis, Alexander E. Lang, Klaus Aktories

Publikováno v: Nature. 508:61-65

Tripartite Tc toxin complexes of bacterial pathogens perforate the host membrane and translocate toxic enzymes into the host cell, including in humans. The underlying mechanism is complex but poorly understood. Here we report the first, to our knowle

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05d2d39f379d5bf488bcaf46f27610bf
https://doi.org/10.1038/nature13015