Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Alexander E, Vlahos"'
Autor:
Alexander E. Vlahos, Jeewoo Kang, Carlos A. Aldrete, Ronghui Zhu, Lucy S. Chong, Michael B. Elowitz, Xiaojing J. Gao
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
To program intercellular communication for biomedicine, it is crucial to regulate the secretion and surface display of signaling proteins. Here the authors develop RELEASE, a modular approach to control intercellular signals using protein-based circu
Externí odkaz:
https://doaj.org/article/f5758511c0d74eabbc000d51e2a946a2
Autor:
Ronghui Zhu, Lucy Chong, Jeewoo Kang, Xiaojing J. Gao, Carlos A. Aldrete, Alexander E. Vlahos, Michael B. Elowitz
To program intercellular communication for biomedicine, it is crucial to regulate the secretion and surface display of signaling proteins. If such regulations are at the protein level, there are additional advantages, including compact delivery and d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::881276d19132d6335b01431f93157a0c
https://doi.org/10.1101/2021.10.18.464444
https://doi.org/10.1101/2021.10.18.464444
Autor:
Alexander E, Vlahos, Jeewoo, Kang, Carlos A, Aldrete, Ronghui, Zhu, Lucy S, Chong, Michael B, Elowitz, Xiaojing J, Gao
Publikováno v:
Nature communications. 13(1)
To program intercellular communication for biomedicine, it is crucial to regulate the secretion and surface display of signaling proteins. If such regulations are at the protein level, there are additional advantages, including compact delivery and d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4e6bb3af1ca0120a8568c9333b4fc5eb
https://pubmed.ncbi.nlm.nih.gov/35177637
https://pubmed.ncbi.nlm.nih.gov/35177637
The subcutaneous space has been shown to be a suitable site for islet transplantation, however an abundance of islets is required to achieve normoglycemia, often requiring multiple donors. The loss of islets is due to the hypoxic conditions islets ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6d99e87d75d0090bec79cef7ca19377
https://doi.org/10.1101/2020.06.26.172148
https://doi.org/10.1101/2020.06.26.172148
Autor:
Alexander E. Vlahos, Michael V. Sefton
The transplantation of pancreatic islets into the portal vein is a promising therapy for the treatment of type I diabetes. However, multiple donors are required due to the substantial loss of islets upon transplantation. Hence, alternative transplant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8f3ee9ea7b7ef126e2eccdd0ba2ea2c3
https://doi.org/10.1016/b978-0-12-814831-0.00020-8
https://doi.org/10.1016/b978-0-12-814831-0.00020-8
Autor:
Tomohiko Adachi, Toshiyuki Adachi, Rodolfo Alejandro, Ana M. Alvarez, Domenico Alvaro, Spencer R. Andrei, Matthew Armfield, Amish Asthana, Stephen F. Badylak, David A. Baidal, Appakalai N. Balamurugan, Gianpaolo Balzano, Ipsita Banerjee, Kaylene Barrera, Will Bataller, Greg J. Beilman, Melena D. Bellin, Dora M. Berman, Louise Berry, Daniel Bojar, Rita Bottino, Nathaniel W. Brigle, Henry Buchwald, Jane N. Buchwald, Vincenzo Cardinale, Guido Carpino, Renee Cercone, Deborah Chaimov, Christopher G. Chapman, Amanda Child, Srinath Chinnakotla, Gaetano Ciancio, Kristin P. Colling, Marie Cook, David K.C. Cooper, Alexandria Coughlan, Rick de Vries, Juan Domínguez-Bendala, Ty B. Dunn, Susumu Eguchi, Massimo Falconi, Austin K. Feeney, Magali J. Fontaine, Benjamin S. Freedman, Virginia Fuenmayor, Martin Fussenegger, Maureen Gannon, Eugenio Gauido, Michael A. Goedde, Rainer W.G. Gruessner, Carolin Hermanns, Masaaki Hidaka, Masataka Hirabaru, Michael G. Hughes, Abid Hussain, Hajime Imamura, Marco Infante, G. Janani, Marlon Jetten, Christopher M. Jones, Jagan Kalivarathan, Mazhar A. Kanak, David L. Kaplan, Tatsuya Kin, Manishekhar Kumar, Jonathan R.T. Lakey, Giacomo Lanzoni, Emily J. Larkin, Esther Latres, Yoojin C. Lee, Elina Linetsky, Gopalakrishnan Loganathan, Elisa Maillard, Biman B. Mandal, Adela Helvia Martinez, Hajime Matsushima, Jeffrey B. Matthews, Kendall McEachron, Raffaella Melzi, Alessia Mercalli, Giovanni Migliaccio, Samantha A. Mitchell, Sami Mohammed, Sean Muir, Rita Nano, Siddharth Narayanan, Koji Natsuda, Jon S. Odorico, Shinichiro Ono, Giuseppe Orlando, Nathalia Padilla, Silvia Pellegrini, Laura Perin, Lorenzo Piemonti, Antonello Pileggi, Catalina Pineda Molina, Elizabeth C. Poli, Mirza Muhammad Fahd Qadir, Camillo Ricordi, L. Rodriguez Rilo, R. Paul Robertson, William Rust, Sara Dutton Sackett, Pratik Saxena, Alexander Schwartzman, Sarah J. Schwarzenberg, Michael V. Sefton, Sidharth Sharma, Benjamin Smood, Davide Socci, Valeria Sordi, Adam Stell, Aaron A. Stock, Mitsuhisa Takatsuki, Alice A. Tomei, Daniel M. Tremmel, Bernard E. Tuch, Vijayaganapathy Vaithilingam, Aart van Apeldoorn, Valentina Villani, Alexander E. Vlahos, Stuart K. Williams, Xiangwei Xiao, Kunal Yadav, Manpei Yamashita, Henryk Zulewski
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cffbb876df39a69858e86447f2d48fb0
https://doi.org/10.1016/b978-0-12-814831-0.09992-9
https://doi.org/10.1016/b978-0-12-814831-0.09992-9
Publikováno v:
Biomaterials. 281:121342
Islet transplantation is a promising regenerative therapy that would reduce the dependence of type 1 diabetic patients on insulin injections. However, islet transplantation is not yet widely available, in part because there is no ideal transplant sit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6748cb3f92d691be4219e9ccb8d5e3f8
https://doi.org/10.1016/j.biomaterials.2021.121342
https://doi.org/10.1016/j.biomaterials.2021.121342
Publikováno v:
Proceedings of the National Academy of Sciences. 114:9337-9342
The transplantation of pancreatic islets, following the Edmonton Protocol, is a promising treatment for type I diabetics. However, the need for multiple donors to achieve insulin independence reflects the large loss of islets that occurs when islets
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::422ea60f24838accb140312739c09d03
https://doi.org/10.1073/pnas.1619216114
https://doi.org/10.1073/pnas.1619216114
Publikováno v:
ACS Biomaterials Science & Engineering. 4:3704-3712
The lack of vascularization limits the creation of engineered tissue constructs with clinically relevant sizes. We pioneered a bottom-up process (modular tissue engineering) in which constructs with intrinsic vasculature were assembled from endotheli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::280501521932d0242b55a18a613b409a
https://doi.org/10.1021/acsbiomaterials.7b00356
https://doi.org/10.1021/acsbiomaterials.7b00356
Publikováno v:
Biomaterials. 131:27-35
Injectable hydrogels are suitable for local cell delivery to the subcutaneous space, but the lack of vasculature remains a limiting factor. Previously we demonstrated that biomaterials containing methacrylic acid promoted vascularization. Here we rep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3032d56eb9c1c8ed06b62e8d82cdb613
https://doi.org/10.1016/j.biomaterials.2017.03.032
https://doi.org/10.1016/j.biomaterials.2017.03.032