Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Alexander Dubeykovskiy"'
Autor:
Zina Dubeykovskaya, Yiling Si, Xiaowei Chen, Daniel L. Worthley, Bernhard W. Renz, Aleksandra M. Urbanska, Yoku Hayakawa, Ting Xu, C. Benedikt Westphalen, Alexander Dubeykovskiy, Duan Chen, Richard A. Friedman, Samuel Asfaha, Karan Nagar, Yagnesh Tailor, Sureshkumar Muthupalani, James G. Fox, Jan Kitajewski, Timothy C. Wang
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
During colorectal inflammation and cancer, myeloid cells accumulate in the spleen and suppress the host immunity response. In this study, the authors use a mouse model of colitis to demonstrate that upon vagus stimulation splenic memory T cells relea
Externí odkaz:
https://doaj.org/article/67d8a761a2b64f5c8b8c4095b1685dfc
Autor:
Massimo Fantini, Justin M. David, Olga Saric, Alexander Dubeykovskiy, Yongzhi Cui, Sharon A. Mavroukakis, Andrew Bristol, Christina M. Annunziata, Kwong Y. Tsang, Philip M. Arlen
Publikováno v:
Frontiers in Immunology, Vol 8 (2018)
NEO-201 is a novel humanized IgG1 monoclonal antibody that was derived from an immunogenic preparation of tumor-associated antigens from pooled allogeneic colon tumor tissue extracts. It was found to react against a variety of cultured human carcinom
Externí odkaz:
https://doaj.org/article/c1fc282fdae44cc7933f1278a62417db
Autor:
Hiroyuki Tomita, Hiroshi Ariyama, Timothy C. Wang, James G. Fox, Harold Frucht, Alexander Dubeykovskiy, Zinaida A. Dubeykovskaya, Wataru Shibata, Sarah Stokes, Sureshkumar Muthupalani, Samuel Asfaha, Richard A. Friedman, Russell Ericksen, Xiangdong Yang
Publikováno v:
Paediatrics Publications
Elsevier
Elsevier
Background & Aims Interleukin (IL)-8 has an important role in initiating inflammation in humans, attracting immune cells such as neutrophils through their receptors CXCR1 and CXCR2. IL-8 has been proposed to contribute to chronic inflammation and can
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8de64fe16ed3aa9a8d8fe8da0b597b35
https://doi.org/10.1053/j.gastro.2012.09.057
https://doi.org/10.1053/j.gastro.2012.09.057
Autor:
Hongshan Wang, Yagnesh Tailor, Kosuke Sakitani, Guangchun Jin, Timothy C. Wang, Ying Jin, Daniel L. Worthley, Alexander Dubeykovskiy
Publikováno v:
Oncotarget
// Guangchun Jin 1, 2 , Kosuke Sakitani 1 , Hongshan Wang 1, 3 , Ying Jin 1 , Alexander Dubeykovskiy 1 , Daniel L. Worthley 4 , Yagnesh Tailor 1 and Timothy C. Wang 1 1 Division of Digestive and Liver Diseases, Department of Medicine, Columbia Univer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03232161df6d8b9d2083339d7c1dd1ae
https://pubmed.ncbi.nlm.nih.gov/28380450
https://pubmed.ncbi.nlm.nih.gov/28380450
Publikováno v:
Journal of Biological Chemistry. 284:3650-3662
The secreted trefoil factor family 2 (TFF2) protein contributes to the protection of the gastrointestinal mucosa from injury by strengthening and stabilizing mucin gels, stimulating epithelial restitution, and restraining the associated inflammation.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8abc990a098c945f2e7e283fc1bc8e9
https://doi.org/10.1074/jbc.m804935200
https://doi.org/10.1074/jbc.m804935200
Autor:
Guangchun Jin, Timothy C. Wang, Vigneshwaran Ramanathan, Shigeo Takaishi, Christoph B. Westphalen, Alexander Dubeykovskiy, Ashley Whelan
Publikováno v:
Cancer investigation. 30(4)
Transgenic mice overexpressing human progastrin (hGAS) show colonic crypt hyper-proliferation and elevated susceptibility to colon carcinogenesis. We aimed to investigate effects of p53 mutation on colon carcinogenesis in hGAS mice. We show that intr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::004161c410465f3beccfeddc97ab1323
https://pubmed.ncbi.nlm.nih.gov/22480191
https://pubmed.ncbi.nlm.nih.gov/22480191
Autor:
Timothy C. Wang, Lindsay J. Wojtukiewicz, Shi Lei, Alexander Dubeykovskiy, Abhijit Chakladar, Jitesh Pratap
Publikováno v:
Biochemical and biophysical research communications. 336(1)
While Wnt and Ras signaling pathways are activated during progression of colorectal cancers, many of their important downstream targets remain to be elucidated. The gastrin gene encodes for a family of peptide growth factors that are commonly upregul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::482073cac5f4b08b6b863b91594b160e
https://pubmed.ncbi.nlm.nih.gov/16139800
https://pubmed.ncbi.nlm.nih.gov/16139800
Publikováno v:
The Journal of biological chemistry. 279(41)
The transforming growth factor-beta (TGF-beta) and Wnt/wingless pathways play critical roles in the specification of cell fate during development and also contribute to cancer formation and progression. Whereas Wnt signaling is clearly pro-oncogenic,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eace0b81efc4c6e3582d695ec712ffbe
https://pubmed.ncbi.nlm.nih.gov/15292219
https://pubmed.ncbi.nlm.nih.gov/15292219
Autor:
Christoph B. Westphalen, Timothy C. Wang, Zinaida A. Dubeykovskaya, Kipyegon Kitur, Samuel Asfaha, Alexander Dubeykovskiy, Daniel L. Worthley
Publikováno v:
Gastroenterology. 143:e25
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::54cba962c314d9949001d093331cd860
https://doi.org/10.1053/j.gastro.2012.07.080
https://doi.org/10.1053/j.gastro.2012.07.080
Autor:
Wataru Shibata, Xiangdong Yang, Hiroyuki Tomita, Samuel Asfaha, Timothy C. Wang, Alexander Dubeykovskiy
Publikováno v:
Gastroenterology. 140:S-182
G A A b st ra ct s polyp number (WT-placebo=3±0.82, WT-DAPT=6.4±1.39). In addition, increased erosion of mucosal layer, infiltration of neutrophils and dysplasia were seen in the polyps of DAPT treated mice compared to placebo both induced with CAC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ec610a204559a24365c1f9d9e6c5c321
https://doi.org/10.1016/s0016-5085(11)60734-8
https://doi.org/10.1016/s0016-5085(11)60734-8