Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Alexander D. Scouras"'
Autor:
Adam R. Offenbacher, Shenshen Hu, Erin M. Poss, Cody A. M. Carr, Alexander D. Scouras, Daniil M. Prigozhin, Anthony T. Iavarone, Ali Palla, Tom Alber, James S. Fraser, Judith P. Klinman
Publikováno v:
ACS Central Science, Vol 3, Iss 6, Pp 570-579 (2017)
Externí odkaz:
https://doaj.org/article/9e694d41cae949cb94870565b513e6ae
Autor:
Daniil M. Prigozhin, Ali Palla, Erin M. Poss, Anthony T. Iavarone, Adam R. Offenbacher, Tom Alber, Alexander D. Scouras, James S. Fraser, Cody A. Marcus Carr, Shenshen Hu, Judith P. Klinman
Publikováno v:
ACS Central Science, Vol 3, Iss 6, Pp 570-579 (2017)
ACS Central Science
ACS Central Science
Defining specific pathways for efficient heat transfer from protein–solvent interfaces to their active sites represents one of the compelling and timely challenges in our quest for a physical description of the origins of enzyme catalysis. Enzymati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d5498bfc3a19973dc8d9b69841e4932
https://doi.org/10.1021/acscentsci.7b00142
https://doi.org/10.1021/acscentsci.7b00142
Autor:
Valerie Daggett, Alexander D. Scouras
Publikováno v:
Protein Science. 20:341-352
We have recently completed systematic molecular dynamics simulations of 807 different proteins representing 95% of the known autonomous protein folds in an effort we refer to as Dynameomics. Here we focus on the analysis of side chain conformations a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2a82485e78d1ab099e5eebf126ca8bc9
https://doi.org/10.1002/pro.565
https://doi.org/10.1002/pro.565
Autor:
Alexander D. Scouras, Valerie Daggett
Publikováno v:
Journal of Materials Science. 43:3625-3637
The misfolding and aggregation of the prion protein (PrP) is the primary cause of a group of infectious neurodegenerative diseases including Creutzfeldt-Jacob disease in humans and Bovine Spongiform Encephalopathy in cows. A single disease can exhibi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6bee62d4f06703ec1c1ac4d9ce7931e7
https://doi.org/10.1007/s10853-008-2578-1
https://doi.org/10.1007/s10853-008-2578-1
Autor:
Sharon Hammes-Schiffer, Alexander D. Scouras, Cody A. Marcus Carr, Judith P. Klinman, Alexander V. Soudackov, Shenshen Hu, Sudhir C. Sharma, Tom Alber
Publikováno v:
Journal of the American Chemical Society, vol 136, iss 23
Journal of the American Chemical Society
Journal of the American Chemical Society
The enzyme soybean lipoxygenase (SLO) has served as a prototype for hydrogen-tunneling reactions, as a result of its unusual kinetic isotope effects (KIEs) and their temperature dependencies. Using a synergy of kinetic, structural, and theoretical st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d11c0c05b1ef42910d2b88da5d10392
https://escholarship.org/uc/item/3zt303b4
https://escholarship.org/uc/item/3zt303b4
Autor:
Valerie Daggett, Alexander D. Scouras
Publikováno v:
Protein engineering, designselection : PEDS. 25(5)
The prion diseases are a class of neurodegenerative diseases caused by the misfolding and aggregation of the prion protein (PrP(C)) into toxic and infectious oligomers (PrP(Sc)). These oligomers are critical to understanding and combating these disea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03af6d25094fc746a8fbf9d6dad1190e
https://pubmed.ncbi.nlm.nih.gov/22447804
https://pubmed.ncbi.nlm.nih.gov/22447804
Autor:
Peter C. Anderson, Noah C. Benson, Dennis Bromley, Steven J. Rysavy, Marc W. van der Kamp, Alexander D. Scouras, Andrew M. Simms, Eric D. Merkley, R. Dustin Schaeffer, Valerie Daggett, David A. C. Beck, Rudesh D. Toofanny, Amanda L. Jonsson
Publikováno v:
Structure (London, England : 1993). 18(4)
The dynamic behavior of proteins is important for an understanding of their function and folding. We have performed molecular dynamics simulations of the native state and unfolding pathways of over 2000 protein/peptide systems (approximately 11,000 i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70693fbeac5d814ee89a9a0e10b4ea20
https://pubmed.ncbi.nlm.nih.gov/20524218
https://pubmed.ncbi.nlm.nih.gov/20524218
Autor:
Samuel D. Gale, Alexander D. Scouras, Elizabeth A. Stoll, Paul E. M. Phillips, Francisco A. Perez, Eric J. Kremer, Richard D. Palmiter, Thomas S. Hnasko, Serge Luquet
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 103(23)
A line of dopamine-deficient (DD) mice was generated to allow selective restoration of normal dopamine signaling to specific brain regions. These DD floxed stop (DDfs) mice have a nonfunctional Tyrosine hydroxylase ( Th ) gene because of insertion of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12afa58ac69e62f20fab9f95867413c3
https://pubmed.ncbi.nlm.nih.gov/16723393
https://pubmed.ncbi.nlm.nih.gov/16723393
Autor:
Alexander D. Scouras, Vishwanath R. Iyer, Andrew D. Ellington, Wei Niu, Edward M. Marcotte, Rammohan Narayanaswamy, Jonathan Davies, Traver Hart
Publikováno v:
The FASEB Journal. 20
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::88660ca5f12d609560d1632d41f28156
https://doi.org/10.1096/fasebj.20.5.lb61-c
https://doi.org/10.1096/fasebj.20.5.lb61-c
Autor:
Rammohan Narayanaswamy, Alexander D. Scouras, Andrew D. Ellington, Vishwanath R. Iyer, Edward M. Marcotte, G. Traver Hart, Jonathan Davies, Wei Niu
Publikováno v:
The FASEB Journal. 20
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::89d99aa2953433bc283afa0419ea7a44
https://doi.org/10.1096/fasebj.20.5.a928-d
https://doi.org/10.1096/fasebj.20.5.a928-d