Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Alexander D. Murphy"'
Autor:
Robert D. Morgan, Cristina Ferreras, Isabel Peset, Egle Avizienyte, Andrew G. Renehan, Richard J. Edmondson, Alexander D. Murphy, Shibani Nicum, Thomas Van Brussel, Andrew R. Clamp, Diether Lambrechts, Cong Zhou, Gordon C. Jayson
Publikováno v:
BMC Medicine, Vol 20, Iss 1, Pp 1-11 (2022)
Highlights Tissue microarrays and germline DNA from women recruited to the phase 3 trial, ICON7, underwent quantitative immunofluorescence for c-MET/VEGFR-2 co-expression and genetic sequencing for single nucleotide polymorphisms (SNPs) VEGF-pathway
Externí odkaz:
https://doaj.org/article/1954157b03284a32b79f59f1c52385eb
Autor:
Robert D. Morgan, Andrew R. Clamp, Daniel J. White, Marcus Price, George J. Burghel, W. David J. Ryder, Reem D. Mahmood, Alexander D. Murphy, Jurjees Hasan, Claire L. Mitchell, Zena Salih, Chelsey Wheeler, Emma Buckley, Joanna Truelove, Georgia King, Yasmina Ainaoui, Sanjeev S. Bhaskar, Joseph Shaw, D. Gareth R. Evans, Bedirhan Kilerci, Simon P. Pearce, Gerard Brady, Caroline Dive, James P.B. O'Connor, Andrew J. Wallace, Dominic G. Rothwell, Richard J. Edmondson, Gordon C. Jayson
Publikováno v:
Clinical Cancer Research. :OF1-OF10
Purpose: A single maintenance course of a PARP inhibitor (PARPi) improves progression-free survival (PFS) in germline BRCA1/2-mutant high-grade serous ovarian cancer (gBRCAm-HGSOC). The feasibility of a second maintenance course of PARPi was unknown.
Autor:
Jordan F Hastings, Alvaro Gonzalez Rajal, Sharissa L Latham, Jeremy ZR Han, Rachael A McCloy, Yolande EI O'Donnell, Monica Phimmachanh, Alexander D Murphy, Adnan Nagrial, Dariush Daneshvar, Venessa Chin, D Neil Watkins, Andrew Burgess, David R Croucher
Publikováno v:
eLife, Vol 9 (2020)
The identification of clinically viable strategies for overcoming resistance to platinum chemotherapy in lung adenocarcinoma has previously been hampered by inappropriately tailored in vitro assays of drug response. Therefore, using a pulse model tha
Externí odkaz:
https://doaj.org/article/6cdc2a0c965744e3b31564628d883756
Autor:
Gordon C. Jayson, Richard J. Edmondson, Dominic G. Rothwell, Andrew J. Wallace, James P.B. O'Connor, Caroline Dive, Gerard Brady, Simon P. Pearce, Bedirhan Kilerci, D. Gareth R. Evans, Joseph Shaw, Sanjeev S. Bhaskar, Yasmina Ainaoui, Georgia King, Joanna Truelove, Emma Buckley, Chelsey Wheeler, Zena Salih, Claire L. Mitchell, Jurjees Hasan, Alexander D. Murphy, Reem D. Mahmood, W. David J. Ryder, George J. Burghel, Marcus Price, Daniel J. White, Andrew R. Clamp, Robert D. Morgan
BRCA2 reversion mutation detected in cell-free circulating DNA from patient 16.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d8190683682e17f23bf7a91a183e796
https://doi.org/10.1158/1078-0432.22490383.v1
https://doi.org/10.1158/1078-0432.22490383.v1
Autor:
Gordon C. Jayson, Richard J. Edmondson, Dominic G. Rothwell, Andrew J. Wallace, James P.B. O'Connor, Caroline Dive, Gerard Brady, Simon P. Pearce, Bedirhan Kilerci, D. Gareth R. Evans, Joseph Shaw, Sanjeev S. Bhaskar, Yasmina Ainaoui, Georgia King, Joanna Truelove, Emma Buckley, Chelsey Wheeler, Zena Salih, Claire L. Mitchell, Jurjees Hasan, Alexander D. Murphy, Reem D. Mahmood, W. David J. Ryder, George J. Burghel, Marcus Price, Daniel J. White, Andrew R. Clamp, Robert D. Morgan
Purpose:A single maintenance course of a PARP inhibitor (PARPi) improves progression-free survival (PFS) in germline BRCA1/2-mutant high-grade serous ovarian cancer (gBRCAm-HGSOC). The feasibility of a second maintenance course of PARPi was unknown.P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::383a4bd467a2e8ab9634c5efb3f01674
https://doi.org/10.1158/1078-0432.c.6533146
https://doi.org/10.1158/1078-0432.c.6533146
Autor:
Gordon C. Jayson, Richard J. Edmondson, Dominic G. Rothwell, Andrew J. Wallace, James P.B. O'Connor, Caroline Dive, Gerard Brady, Simon P. Pearce, Bedirhan Kilerci, D. Gareth R. Evans, Joseph Shaw, Sanjeev S. Bhaskar, Yasmina Ainaoui, Georgia King, Joanna Truelove, Emma Buckley, Chelsey Wheeler, Zena Salih, Claire L. Mitchell, Jurjees Hasan, Alexander D. Murphy, Reem D. Mahmood, W. David J. Ryder, George J. Burghel, Marcus Price, Daniel J. White, Andrew R. Clamp, Robert D. Morgan
Supplementary Methodology.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ac4b273d975d5742c671ed36cc435ae
https://doi.org/10.1158/1078-0432.22490380
https://doi.org/10.1158/1078-0432.22490380
Autor:
Gordon C. Jayson, Richard J. Edmondson, Dominic G. Rothwell, Andrew J. Wallace, James P.B. O'Connor, Caroline Dive, Gerard Brady, Simon P. Pearce, Bedirhan Kilerci, D. Gareth R. Evans, Joseph Shaw, Sanjeev S. Bhaskar, Yasmina Ainaoui, Georgia King, Joanna Truelove, Emma Buckley, Chelsey Wheeler, Zena Salih, Claire L. Mitchell, Jurjees Hasan, Alexander D. Murphy, Reem D. Mahmood, W. David J. Ryder, George J. Burghel, Marcus Price, Daniel J. White, Andrew R. Clamp, Robert D. Morgan
Liquid biopsy time points.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e6c35925d33a5ace1475cad8e3ca56f
https://doi.org/10.1158/1078-0432.22490371
https://doi.org/10.1158/1078-0432.22490371
Autor:
Robert D, Morgan, Cristina, Ferreras, Isabel, Peset, Egle, Avizienyte, Andrew G, Renehan, Richard J, Edmondson, Alexander D, Murphy, Shibani, Nicum, Thomas, Van Brussel, Andrew R, Clamp, Diether, Lambrechts, Cong, Zhou, Gordon C, Jayson
Publikováno v:
BMC medicine. 20(1)
Bevacizumab improves survival outcomes in women diagnosed with epithelial ovarian cancer (EOC). Pre-clinical data showed that the c-MET/VEGFR-2 heterocomplex negates VEGF inhibition through activation of c-MET signalling, leading to a more invasive a
Autor:
Alvaro Gonzalez Rajal, Sharissa L. Latham, Rachael A. McCloy, D. Neil Watkins, Jeremy Z. R. Han, Dariush Daneshvar, Andrew Burgess, Adnan Nagrial, Monica Phimmachanh, Alexander D Murphy, Venessa T. Chin, Jordan F. Hastings, David R. Croucher, Yolande E. I. O’Donnell
Publikováno v:
eLife
eLife, Vol 9 (2020)
eLife, Vol 9 (2020)
The identification of clinically viable strategies for overcoming resistance to platinum chemotherapy in lung adenocarcinoma has previously been hampered by inappropriately tailored in vitro assays of drug response. Therefore, using a pulse model tha
Autor:
Dariush Daneshvar, Venessa T. Chin, Jordan F. Hastings, David R. Croucher, Yolande E. I. O’Donnell, Sharissa L. Latham, Jeremy Z. R. Han, Alvaro Gonzalez Rajal, Andrew Burgess, D. Neil Watkins, Adnan Nagrial, Rachael A. McCloy, Monica Phimmachanh, Alexander D Murphy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a7d20e95f6c679ac72ba22ef9028d9e3
https://doi.org/10.7554/elife.53367.sa2
https://doi.org/10.7554/elife.53367.sa2