Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Alexander D. Law"'
Autor:
Jun Yang, Yujuan Song, Alexander D. Law, Conner J. Rogan, Kelsey Shimoda, Danijel Djukovic, Jeffrey C. Anderson, Doris Kretzschmar, David A. Hendrix, Jadwiga M. Giebultowicz
Publikováno v:
Frontiers in Aging, Vol 3 (2022)
Blue light (BL) is becoming increasingly prevalent in artificial illumination, raising concerns about its potential health hazard to humans. In fact, there is evidence suggesting that acute BL exposure may lead to oxidative stress and death of retina
Externí odkaz:
https://doaj.org/article/86ef98bb2b204c55afe828ffcf464c6c
Autor:
Alexander D. Law, Marlène Cassar, Dani M. Long, Eileen S. Chow, Jadwiga M. Giebultowicz, Anjana Venkataramanan, Roland Strauss, Doris Kretzschmar
Publikováno v:
Neurobiology of Disease, Vol 170, Iss , Pp 105770- (2022)
Although mutations in the microtubules-associated protein Tau have long been connected with several neurodegenerative diseases, the underlying molecular mechanisms causing these tauopathies are still not fully understood. Studies in various models su
Externí odkaz:
https://doaj.org/article/5662c98be9934fca882e7065b3adf1e7
Autor:
Trevor R. Nash, Eileen S. Chow, Alexander D. Law, Samuel D. Fu, Elzbieta Fuszara, Aleksandra Bilska, Piotr Bebas, Doris Kretzschmar, Jadwiga M. Giebultowicz
Publikováno v:
npj Aging and Mechanisms of Disease, Vol 5, Iss 1, Pp 1-8 (2019)
Abstract Light is necessary for life, but prolonged exposure to artificial light is a matter of increasing health concern. Humans are exposed to increased amounts of light in the blue spectrum produced by light-emitting diodes (LEDs), which can inter
Externí odkaz:
https://doaj.org/article/b5a13df9da704333ac49a61936553663
Publikováno v:
Frontiers in Neuroscience, Vol 14 (2020)
A hallmark feature of Alzheimer’s disease (AD) and other Tauopathies, like Frontotemporal Dementia with Parkinsonism linked to chromosome 17 (FTDP-17), is the accumulation of neurofibrillary tangles composed of the microtubule-associated protein Ta
Externí odkaz:
https://doaj.org/article/6b32aeac766e4116acc3e5210b2b4f86
Publikováno v:
Frontiers in Neuroscience, Vol 13 (2019)
Mutations in patatin-like phospholipase domain-containing protein 6 (PNPLA6) have been linked with a number of inherited diseases with clinical symptoms that include spastic paraplegia, ataxia, and chorioretinal dystrophy. PNPLA6 is an evolutionary c
Externí odkaz:
https://doaj.org/article/17b640c442e747aab4fae475d28d8d34
ER responses play a key role in Swiss-Cheese/Neuropathy Target Esterase-associated neurodegeneration
Publikováno v:
Neurobiology of Disease, Vol 130, Iss , Pp 104520- (2019)
Swiss Cheese (SWS) is the Drosophila orthologue of Neuropathy Target Esterase (NTE), a phospholipase that when mutated has been shown to cause a spectrum of disorders in humans that range from intellectual disabilities to ataxia. Loss of SWS in Droso
Externí odkaz:
https://doaj.org/article/b9fbc0c758764243833c4bac06530d23
Autor:
Yujuan Song, Jun Yang, Alexander D. Law, David A. Hendrix, Doris Kretzschmar, Matthew Robinson, Jadwiga M. Giebultowicz
Publikováno v:
npj Aging. 8
Blue light is a predominant component of light emitting devices (LEDs), which are increasingly present in our environment. There is already accumulating evidence that blue light exposure causes damage to retinal cells in vitro and in vivo; however, m
Publikováno v:
Frontiers in Neuroscience, Vol 13 (2019)
Mutations in patatin-like phospholipase domain-containing protein 6 (PNPLA6) have been linked with a number of inherited diseases with clinical symptoms that include spastic paraplegia, ataxia, and chorioretinal dystrophy. PNPLA6 is an evolutionary c
Publikováno v:
The Journal of experimental biology. 222(Pt 1)
TAR DNA-binding protein 43 (TDP-43) is an RNA-binding protein that regulates transcription, translation and alternative splicing of mRNA. We have shown previously that null mutations of the Drosophila ortholog, Tar DNA-binding homolog (tbph), causes
Publikováno v:
Journal of Experimental Biology.
Tar DNA binding protein 43 (TDP-43) is an RNA binding protein that regulates transcription, translation, and alternative splicing of mRNA. We have shown previously that null mutations of the Drosophila orthologue, Tar DNA-binding homologue (tbph), ca