Výsledky vyhledávání - "Alexander D. Jeffs"

Akademický článek

The role of leukotriene inhibition using a 5‐lipoxygenase (5‐LO) inhibitor in a joint contracture model

Autor: Alexander D. Jeffs, Michael Boyd, Landon Larabee, Matthew Shelton, Alexander Bassil, Ross Taylor, David Berkoff

Publikováno v: Journal of Experimental Orthopaedics, Vol 10, Iss 1, Pp n/a-n/a (2023)

Abstract Purpose Arthrofibrosis is a common inflammatory complication of joint trauma and surgery. 5lipoxygenase (5‐LO) is a key enzyme involved in inflammation. Inhibition of 5‐LO has been shown to reduce inflammation in heart and lung models bu

Externí odkaz: https://doaj.org/article/4ce0a946e3194d65837633c3ce3f881d

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2-Octyl Cyanoacrylate (Dermabond®) Inhibits Bridging Bone Formation of Articular Fractures in a Rat Model

Autor: Reid W. Draeger, Anthony V. Paterno, Mark A. Cairns, Paul S. Weinhold, Vincent Gomez, Benjamin A Bortner, Alexander D. Jeffs, Laurence E. Dahners

Publikováno v: Cureus

One technique often used for small intraarticular fracture fixation involves the use of 2-octyl-cyanoacrylate (2-OCTA) (Dermabond®, Ethicon, Inc., Raritan, USA). The purpose of this study was to determine if 2-OCTA impedes bony healing. Osteochondra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e01ae8649f5a9149da0058ee20d29f9e
http://europepmc.org/articles/PMC8403484

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Stimulating Type 1 Angiotensin Receptors on T Lymphocytes Attenuates Renal Fibrosis

Autor: Steven D. Crowley, Alexander D. Jeffs, Yi Wen, Nathan P. Rudemiller, Xiaohan Lu, Jamie R. Privratsky, Jiafa Ren, Jiandong Zhang, Robert Griffiths

Publikováno v: Am J Pathol

Most forms of chronic kidney disease culminate in renal fibrosis that heralds organ failure. In contrast to the protective effects of globally blocking type 1 angiotensin (AT(1)) receptors throughout the body, activating AT(1) receptors directly on i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c2f678dd7868b3b3eb182d33e891faf
https://europepmc.org/articles/PMC6521889/

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C-C Motif Chemokine 5 Attenuates Angiotensin II–Dependent Kidney Injury by Limiting Renal Macrophage Infiltration

Autor: Jiandong Zhang, Steven D. Crowley, Mehul B. Patel, Michael D. Gunn, Anne F. Buckley, Robert Griffiths, Nathan P. Rudemiller, Alexander D. Jeffs, Matthew J. Kan, Norah S. Karlovich

Publikováno v: The American Journal of Pathology. 186:2846-2856

Inappropriate activation of the renin angiotensin system (RAS) is a key contributor to the pathogenesis of essential hypertension. During RAS activation, infiltration of immune cells into the kidney exacerbates hypertension and renal injury. However,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::182105d7ce5226981dccba6612b1bb3e
https://doi.org/10.1016/j.ajpath.2016.07.015

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Competing Actions of Type 1 Angiotensin II Receptors Expressed on T Lymphocytes and Kidney Epithelium during Cisplatin-Induced AKI

Autor: Steven D. Crowley, Marcela Herrera, Norah S. Karlovich, Sergei A. Nedospasov, Min Wu, Jiandong Zhang, Jamie R. Privratsky, Matthew A. Sparks, Susan B. Gurley, Nathan P. Rudemiller, Qingqing Wei, Mehul B. Patel, Alexander D. Jeffs

Publikováno v: Journal of the American Society of Nephrology. 27:2257-2264

Inappropriate activation of the renin-angiotensin system (RAS) contributes to many CKDs. However, the role of the RAS in modulating AKI requires elucidation, particularly because stimulating type 1 angiotensin II (AT1) receptors in the kidney or circ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::589357da3bc1ca39c765b98b96b11b4f
https://doi.org/10.1681/asn.2015060683

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