Zobrazeno 1 - 10
of 82
pro vyhledávání: '"Alexander D McLellan"'
Publikováno v:
PLoS ONE, Vol 15, Iss 7, p e0232915 (2020)
Chimeric antigen receptor (CAR) T cell therapy is an effective treatment for B cell malignancies, with emerging potential for the treatment of other hematologic cancers and solid tumors. The strength of the promoter within the CAR cassette will alter
Externí odkaz:
https://doaj.org/article/30e3408f75df4963958e005581722360
Publikováno v:
Clinical & Translational Immunology, Vol 8, Iss 5, Pp n/a-n/a (2019)
Abstract Costimulatory signals are required to achieve robust chimeric antigen receptor (CAR) T cell expansion, function, persistence and antitumor activity. These can be provided by incorporating intracellular signalling domains from one or more T c
Externí odkaz:
https://doaj.org/article/faf44b2f06044f53ba2c44b8713bec79
Autor:
Wenzel Czepluch, Amy C Dunn, Charlotte L Everitt, Dominik Dorer, Sarah C Saunderson, Frank E Aldwell, Alexander D McLellan
Publikováno v:
International Journal of Mycobacteriology, Vol 2, Iss 1, Pp 44-50 (2013)
Oral vaccination with BCG provides protective systemic immunity against pathogenic mycobacterial challenge. In this study, the anatomical distribution of Mycobacterium bovis BCG following oral vaccination was investigated. Replicating bacteria in the
Externí odkaz:
https://doaj.org/article/0dc5f9948f2f4ab89db6931fe4a4b4aa
Autor:
Seyed Mohammad Ali Hosseini Rad, Joshua Colin Halpin, Supannikar Tawinwung, Koramit Suppipat, Nattiya Hirankarn, Alexander D McLellan
Publikováno v:
Immunology & Cell Biology. 100:424-439
Advances made in chimeric antigen receptor (CAR) T cell therapy have revolutionized the treatment and management of certain cancers. Currently, B cell malignancies have been among the few cancers to which CAR T cells have shown persistent and resilie
Autor:
Dhammika Leshan Wannigama, Mohan Amarasiri, Parichart Hongsing, Cameron Hurst, Charin Modchang, Sudarat Chadsuthi, Suparinthon Anupong, Phatthranit Phattharapornjaroen, Ali Hosseini Rad S.M., Stefan Fernandez, Angkana T. Huang, Naris Kueakulpattana, Chanikan Tanasatitchai, Porames Vatanaprasan, Thammakorn Saethang, Sirirat Luk-in, Robin James Storer, Puey Ounjai, Naveen Kumar Devanga Ragupathi, Phitsanuruk Kanthawee, Daisuke Sano, Takashi Furukawa, Kazunari Sei, Asada Leelahavanichkul, Talerngsak Kanjanabuch, Nattiya Hirankarn, Paul G. Higgins, Anthony Kicic, Tanittha Chatsuwan, Alexander D. McLellan, Shuichi Abe
Publikováno v:
The Science of the total environment. 858(Pt 1)
The monkeypox virus is excreted in the feces of infected individuals. Therefore, there is an interest in using viral load detection in wastewater for sentinel early surveillance at a community level and as a complementary approach to syndromic survei
Publikováno v:
Genes. 13:1679
Tetracycline-inducible systems are widely used control elements for mammalian gene expression. Despite multiple iterations to improve inducibility, their use is still compromised by basal promoter activity in the absence of tetracyclines. In a mammal
Publikováno v:
Immunology & Cell Biology. 97:664-674
It is now becoming clear that less differentiated naive and memory T cells are superior to effector T cells in the transfer of immunity for adoptive cell therapy. This review will outline the challenges faced by chimeric antigen receptor (CAR) T cell
Autor:
Mojtaba Mollaei, Samuel W J Smith Bell, Ali Hosseini Rad S M, Joshua Colin Halpin, Alexander D. McLellan, Nattiya Hirankarn
Publikováno v:
Cancers
Cancers, Vol 13, Iss 1229, p 1229 (2021)
Cancers, Vol 13, Iss 1229, p 1229 (2021)
Simple Summary We review the mechanisms of cellular metabolism and mitochondrial function that have potential to impact on the success of chimeric antigen receptor (CAR) T cell therapy. The review focuses readers on mitochondrial functions to allow a
Publikováno v:
Cancers. 14:978
The precision guiding of endogenous or adoptively transferred lymphocytes to the solid tumour mass is obligatory for optimal anti-tumour effects and will improve patient safety. The recognition and elimination of the tumour is best achieved when anti
Publikováno v:
On Demand Talks.
Background CAR T cell therapy has been successful for targeting blood cancers, but treatment of solid cancers has been limited due to the heterogenous nature of tumour-associated antigen expression on solid cancers, and the suppressive tumour microen