Toward precision immunotherapy using multiplex immunohistochemistry and in silico methods to define the tumor immune microenvironment

Autor: Ryan Hutchinson, Alexander D. Barrow, Yitong Fang, Samuel S Widodo, Stefano Mangiola, Christopher M. Hovens, Stanley S. Stylli, Theo Mantamadiotis, Marija Dinevska, Phillip K. Darcy, Paul J Neeson

Publikováno v: Cancer Immunology, Immunotherapy. 70:1811-1820

Recent developments in cancer immunotherapy promise better outcomes for cancer patients, although clinical trials for difficult to treat cancers such as malignant brain cancer present special challenges, showing little response to first generation im

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::aac30ab4147739d83deab1db1de018d2
https://doi.org/10.1007/s00262-020-02801-7

A Transcriptional Signature of IL-2 Expanded Natural Killer Cells Predicts More Favorable Prognosis in Bladder Cancer

Autor: Yaseelan Palarasah, Alexander James Sedgwick, Abdullah-Al-Kamran Khan, Stefano Mangiola, Alexander D. Barrow, Yuhan Sun

Publikováno v: Frontiers in Immunology
Sun, Y, Sedgwick, A J, Khan, M A-A-K, Palarasah, Y, Mangiola, S & Barrow, A D 2021, ' A Transcriptional Signature of IL-2 Expanded Natural Killer Cells Predicts More Favorable Prognosis in Bladder Cancer ', Frontiers in Immunology, vol. 12, 724107 . https://doi.org/10.3389/fimmu.2021.724107
Frontiers in Immunology, Vol 12 (2021)

Activation of natural killer (NK) cell function is regulated by cytokines, such as IL-2, and secreted factors upregulated in the tumor microenvironment, such as platelet-derived growth factor D (PDGF-DD). In order to elucidate a clinical role for the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80c8e320c18c7bffaa7fdc7d7bb366bb
https://doi.org/10.3389/fimmu.2021.724107

Sialic acid-binding immunoglobulin-like lectin (Sigelac)-15 is a rapidly internalised cell-surface antigen expressed by acute myeloid leukaemia cells

Autor: Huan Cao, John Elvin, Emma Gudgin, Andreas Neerincx, Brian J. P. Huntly, John Trowsdale, Bernard de Bono, Clare Pridans, Mark A. Vickers, Ursula Lakner, Catherine Huntington, Alexander D. Barrow

Publikováno v: British journal of haematologyReferences. 193(5)

Sialic acid-binding immunoglobulin-like lectin (Siglec)-15 has recently been identified as a critical tumour checkpoint, augmenting the expression and function of programmed death-ligand 1. We raised a monoclonal antibody, A9E8, specific for Siglec-1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::388773a8451fc26b3bf0137607c08c93
https://pubmed.ncbi.nlm.nih.gov/33951750

Cellular expression, trafficking, and function of two isoforms of human ULBP5/RAET1G.

Autor: Robert A Eagle, Gillian Flack, Anthony Warford, Jesús Martínez-Borra, Insiya Jafferji, James A Traherne, Maki Ohashi, Louise H Boyle, Alexander D Barrow, Sophie Caillat-Zucman, Neil T Young, John Trowsdale

Publikováno v: PLoS ONE, Vol 4, Iss 2, p e4503 (2009)

BackgroundThe activating immunoreceptor NKG2D is expressed on Natural Killer (NK) cells and subsets of T cells. NKG2D contributes to anti-tumour and anti-viral immune responses in vitro and in vivo. The ligands for NKG2D in humans are diverse protein

Externí odkaz: https://doaj.org/article/fc713ba0efb440538c1dc3d4584813bd

Tailoring Natural Killer cell immunotherapy to the tumour microenvironment

Autor: Marco Colonna, Alexander D. Barrow

Publikováno v: Seminars in Immunology. 31:30-36

Natural killer (NK) cells are cytotoxic and cytokine-secreting cells that can mediate potent anti-tumour activity. Accumulating evidence indicates that NK cell functions are severely compromised within the confines of the tumour microenvironment thus

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ae2bd16f92fce7c87d3ede656ade920
https://doi.org/10.1016/j.smim.2017.09.001