Zobrazeno 1 - 10
of 220
pro vyhledávání: '"Alexander D, Verin"'
Autor:
Evgenia Gerasimovskaya, Rahul S. Patil, Adrian Davies, McKenzie E. Maloney, Liselle Simon, Basmah Mohamed, Mary Cherian-Shaw, Alexander D. Verin
Publikováno v:
Frontiers in Physiology, Vol 15 (2024)
The purinergic signaling system is an evolutionarily conserved and critical regulatory circuit that maintains homeostatic balance across various organ systems and cell types by providing compensatory responses to diverse pathologies. Despite cardiova
Externí odkaz:
https://doaj.org/article/42e1427200574c2595c2de227c691497
Autor:
Praneet Veerapaneni, Brandee Goo, Samah Ahmadieh, Hong Shi, David S. Kim, Mourad Ogbi, Stephen Cave, Ronnie Chouhaita, Nicole Cyriac, David J. Fulton, Alexander D. Verin, Weiqin Chen, Yun Lei, Xin-Yun Lu, Ha Won Kim, Neal L. Weintraub
Publikováno v:
Biomolecules, Vol 14, Iss 4, p 494 (2024)
Histone deacetylase (HDAC) 9 is a negative regulator of adipogenic differentiation, which is required for maintenance of healthy adipose tissues. We reported that HDAC9 expression is upregulated in adipose tissues during obesity, in conjunction with
Externí odkaz:
https://doaj.org/article/4f86865224ed43ec834dcb37d6130824
Autor:
Rahul S. Patil, McKenzie E. Maloney, Rudolf Lucas, David J. R. Fulton, Vijay Patel, Zsolt Bagi, Anita Kovacs-Kasa, Laszlo Kovacs, Yunchao Su, Alexander D. Verin
Publikováno v:
Biomolecules, Vol 14, Iss 2, p 140 (2024)
A monolayer of endothelial cells (ECs) lines the lumen of blood vessels and, as such, provides a semi-selective barrier between the blood and the interstitial space. Compromise of the lung EC barrier due to inflammatory or toxic events may result in
Externí odkaz:
https://doaj.org/article/13389f60a41a4945b12c9ded7ddd2c0f
Autor:
Rahul S. Patil, Anita Kovacs-Kasa, Boris A. Gorshkov, David J. R. Fulton, Yunchao Su, Robert K. Batori, Alexander D. Verin
Publikováno v:
Biomedicines, Vol 11, Iss 6, p 1638 (2023)
Vascular barrier dysfunction is characterized by increased permeability and inflammation of endothelial cells (ECs), which are prominent features of acute lung injury (ALI), acute respiratory distress syndrome (ARDS), and sepsis, and a major complica
Externí odkaz:
https://doaj.org/article/ca6912e799864577b025471f55d1cc1f
Autor:
Robert K. Batori, Feng Chen, Zsuzsanna Bordan, Stephen Haigh, Yunchao Su, Alexander D. Verin, Scott A. Barman, David W. Stepp, Trinad Chakraborty, Rudolf Lucas, David J. R. Fulton
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Pneumolysin (PLY) is a bacterial pore forming toxin and primary virulence factor of Streptococcus pneumonia, a major cause of pneumonia. PLY binds cholesterol-rich domains of the endothelial cell (EC) plasma membrane resulting in pore assembly and in
Externí odkaz:
https://doaj.org/article/a855244bd2ed44449d1488efd66170f2
Autor:
Qian Ma, Qiuhua Yang, Jiean Xu, Hunter G Sellers, Zach L Brown, Zhiping Liu, Zsuzsanna Bordan, Xiaofan Shi, Dingwei Zhao, Yongfeng Cai, Vidhi Pareek, Chunxiang Zhang, Guangyu Wu, Zheng Dong, Alexander D Verin, Lin Gan, Quansheng Du, Stephen J Benkovic, Suowen Xu, John M Asara, Issam Ben-Sahra, Scott Barman, Yunchao Su, David J R Fulton, Yuqing Huo
Publikováno v:
European Heart Journal. 44:1265-1279
Aims Proliferation of vascular smooth muscle cells (VSMCs) is a hallmark of pulmonary hypertension (PH). Proliferative cells utilize purine bases from the de novo purine synthesis (DNPS) pathways for nucleotide synthesis; however, it is unclear wheth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9329c8bdebe442e7d6f812bed7c84572
https://doi.org/10.1093/eurheartj/ehad044
https://doi.org/10.1093/eurheartj/ehad044
Autor:
Xueyi Li, Yanfang Yu, Boris Gorshkov, Stephen Haigh, Zsuzsanna Bordan, Daniel Weintraub, Radu Daniel Rudic, Trinad Chakraborty, Scott A. Barman, Alexander D. Verin, Yunchao Su, Rudolf Lucas, David W. Stepp, Feng Chen, David J. R. Fulton
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Pneumonia is a leading cause of death in children and the elderly worldwide, accounting for 15% of all deaths of children under 5 years old. Streptococcus pneumoniae is a common and aggressive cause of pneumonia and can also contribute to meningitis
Externí odkaz:
https://doaj.org/article/f70a72936b734b8b8fcae30c5e3a0770
Autor:
Istvan Czikora, Abdel A. Alli, Supriya Sridhar, Michael A. Matthay, Helena Pillich, Martina Hudel, Besim Berisha, Boris Gorshkov, Maritza J. Romero, Joyce Gonzales, Guangyu Wu, Yuqing Huo, Yunchao Su, Alexander D. Verin, David Fulton, Trinad Chakraborty, Douglas C. Eaton, Rudolf Lucas
Publikováno v:
Frontiers in Immunology, Vol 8 (2017)
BackgroundStreptococcus pneumoniae is a major etiologic agent of bacterial pneumonia. Autolysis and antibiotic-mediated lysis of pneumococci induce release of the pore-forming toxin, pneumolysin (PLY), their major virulence factor, which is a promine
Externí odkaz:
https://doaj.org/article/e00463dfbf08482284ebe0f2bdc7fe4c
Autor:
Shivakumar Subbanna, Madhu Shivakumar, Nagavedi S. Umapathy, Mariko Saito, Panaiyur S. Mohan, Asok Kumar, Ralph A. Nixon, Alexander D. Verin, Delphine Psychoyos, Balapal S. Basavarajappa
Publikováno v:
Neurobiology of Disease, Vol 54, Iss , Pp 475-485 (2013)
Rodent exposure to binge-like ethanol during postnatal day 7 (P7), which is comparable to the third trimester of human pregnancy, induces neuronal cell loss. However, the molecular mechanisms underlying these neuronal losses are still poorly understo
Externí odkaz:
https://doaj.org/article/0cf56506ca7547cd8cfc143540712148
Autor:
Anita Kovacs-Kasa, Mary Cherian-Shaw, Christine Gross, Alexander D. Verin, Mary L Meadows, David J. Fulton
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
Scientific Reports
Scientific Reports
Lipopolysaccharide (LPS), a component of the outer membrane of gram-negative bacteria, disrupts the alveolar-capillary barrier, triggering pulmonary vascular leak thus inducing acute lung injury (ALI). Extracellular purines, adenosine and ATP, protec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64c0eed69da45ddf52c2955b79e5ae04
http://link.springer.com/article/10.1038/s41598-020-75224-0
http://link.springer.com/article/10.1038/s41598-020-75224-0