Zobrazeno 1 - 10
of 83
pro vyhledávání: '"Alexander D, Crawford"'
Autor:
Gia Melikishvili, Pasquale Striano, Elham Shojeinia, Tamar Gachechiladze, Ekaterine Kurua, Nazhi Tabatadze, Mariam Melikishvili, Otar Koniashvili, Gvantsa Khachiashvili, Nino Epitashvili, Gamirova Rimma, Oleg Belyaev, Tatyana Tomenko, Volodymyr Kharytonov, Ulviyya Guliyeva, Camila V. Esguerra, Alexander D. Crawford, Olivier Dulac
Publikováno v:
Epilepsia Open, Vol 9, Iss 5, Pp 1972-1980 (2024)
Abstract CHD2‐related epilepsy is characterized by early‐onset photosensitive myoclonic epilepsy with developmental delay and a high rate of pharmacoresistance. We sought to evaluate the efficacy of acetazolamide (ACZ) in CHD2‐related epilepsy,
Externí odkaz:
https://doaj.org/article/e5aa511207164ad89a4056dd55618203
Autor:
Elham Shojaeinia, Teresa L. Mastracci, Remon Soliman, Orrin Devinsky, Camila V. Esguerra, Alexander D. Crawford
Publikováno v:
Molecular Brain, Vol 17, Iss 1, Pp 1-10 (2024)
Abstract DHPS deficiency syndrome is an ultra-rare neurodevelopmental disorder (NDD) which results from biallelic mutations in the gene encoding the enzyme deoxyhypusine synthase (DHPS). DHPS is essential to synthesize hypusine, a rare amino acid for
Externí odkaz:
https://doaj.org/article/bf1fc1b2f36c455288d30524565c49a3
Autor:
Kathiresan Purushothaman, Alexander D. Crawford, Sérgio D.C. Rocha, Aleksandar B. Göksu, Byron Morales Lange, Liv Torunn Mydland, Shubha Vij, Lin Qingsong, Margareth Øverland, Charles McL. Press
Publikováno v:
Heliyon, Vol 10, Iss 5, Pp e26547- (2024)
Yeasts contain bioactive components that can enhance fish immune robustness and disease resistance. Our study focused on analyzing intestinal immunoregulatory pathways in zebrafish (Danio rerio) using iTRAQ and 2D LC-MS/MS to quantify intestinal prot
Externí odkaz:
https://doaj.org/article/ce7d47a82d004588bcc32aabf871fe92
Autor:
Remon Soliman, Maria Lorena Cordero-Maldonado, Teresa G. Martins, Mahsa Moein, Jean-François Conrotte, Rebeccah A. Warmack, Alexander Skupin, Alexander D. Crawford, Steven G. Clarke, Carole L. Linster
Publikováno v:
Frontiers in Genetics, Vol 11 (2021)
Isomerization of l-aspartyl and l-asparaginyl residues to l-isoaspartyl residues is one type of protein damage that can occur under physiological conditions and leads to conformational changes, loss of function, and enhanced protein degradation. Prot
Externí odkaz:
https://doaj.org/article/acd904b14ec240748fb3a76b7e3b8d6d
Autor:
Sofia Kokkaliari, Kim Pham, Nargess Shahbazi, Laurent Calcul, Lukasz Wojtas, Nerida G. Wilson, Alexander D. Crawford, Bill J. Baker
Publikováno v:
Marine Drugs, Vol 20, Iss 3, p 196 (2022)
Five new alkaloids have been isolated from the lipophilic extract of the Antarctic tunicate Synoicum sp. Deep-sea specimens of Synoicum sp. were collected during a 2011 cruise of the R/V Nathanial B. Palmer to the southern Scotia Arc, Antarctica. Cru
Externí odkaz:
https://doaj.org/article/76fea00d4e554751a6dcf80dc943ada0
Autor:
Daniëlle Copmans, Sara Kildgaard, Emma Roux, Michèle Partoens, Gert Steurs, Xinhui Wang, Wim M. De Borggraeve, Camila V. Esguerra, Alexander D. Crawford, Thomas O. Larsen, Peter A. M. de Witte
Publikováno v:
Pharmaceuticals, Vol 15, Iss 2, p 247 (2022)
PharmaSea performed large-scale in vivo screening of marine natural product (MNP) extracts, using zebrafish embryos and larvae, to identify compounds with the potential to treat epilepsy. In this study, we report the discovery of two new antiseizure
Externí odkaz:
https://doaj.org/article/367a45b4e88e4608b3466080bf98c684
Autor:
Maria Lorena Cordero-Maldonado, Simon Perathoner, Kees-Jan van der Kolk, Ralf Boland, Ursula Heins-Marroquin, Herman P Spaink, Annemarie H Meijer, Alexander D Crawford, Jan de Sonneville
Publikováno v:
PLoS ONE, Vol 14, Iss 1, p e0202377 (2019)
One of the most popular techniques in zebrafish research is microinjection. This is a rapid and efficient way to genetically manipulate early developing embryos, and to introduce microbes, chemical compounds, nanoparticles or tracers at larval stages
Externí odkaz:
https://doaj.org/article/1266eb973f8b4260b2fc9f1f5fb3c912
Autor:
Ursula Heins-Marroquin, Randolph R. Singh, Simon Perathoner, Floriane Gavotto, Carla Merino Ruiz, Myrto Patraskaki, Gemma Gomez-Giro, Felix Kleine Borgmann, Melanie Meyer, Anaïs Carpentier, Marc O. Warmoes, Christian Jäger, Michel Mittelbronn, Jens C. Schwamborn, Maria Lorena Cordero-Maldonado, Alexander D. Crawford, Emma L. Schymanski, Carole Linster
Juvenile Neuronal Ceroid Lipofuscinosis (or Batten disease) is an autosomal recessive, rare neurodegenerative disorder that affects mainly children above the age of 5 years and is most commonly caused by mutations in the highly conservedCLN3gene. Her
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::928be4d0d97e0657c373023c96c67d4f
https://doi.org/10.1101/2023.03.17.533107
https://doi.org/10.1101/2023.03.17.533107
Autor:
Théo Brillatz, Chiara Lauritano, Maxime Jacmin, Supitcha Khamma, Laurence Marcourt, Davide Righi, Giovanna Romano, Francesco Esposito, Adrianna Ianora, Emerson F Queiroz, Jean-Luc Wolfender, Alexander D Crawford
Publikováno v:
PLoS ONE, Vol 13, Iss 4, p e0196195 (2018)
With the goal of identifying neuroactive secondary metabolites from microalgae, a microscale in vivo zebrafish bioassay for antiseizure activity was used to evaluate bioactivities of the diatom Skeletonema marinoi, which was recently revealed as bein
Externí odkaz:
https://doaj.org/article/4dcdc4eae00f4c7e998f5244e8348653
Autor:
Eric Allémann, Jean-Luc Wolfender, Théo Brillatz, Antonella Riva, Nargess Shahbazi, Alexander D. Crawford, Emerson Ferreira Queiroz, Nathalie Boulens, Maxime Jacmin, Laurence Marcourt, Hugo Morin
Publikováno v:
ACS Chemical Neuroscience. 12:1791-1801
The resin of the tree Boswellia sacra Flueck. (synonym: B. carterii; Burseraceae), also known as "frankincense", is a traditional remedy used for central nervous system disorders in East Africa. Here we report the evaluation of its antiseizure activi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0304359998c778aa6db725cc85c47d45
https://doi.org/10.1021/acschemneuro.1c00044
https://doi.org/10.1021/acschemneuro.1c00044