Zobrazeno 1 - 10
of 391
pro vyhledávání: '"Alexander D, Borowsky"'
Autor:
Jihao Xu, Jae‐Seok Roe, EunJung Lee, Claudia Tonelli, Keely Y. Ji, Omar W. Younis, Tim D.D. Somervile, Melissa Yao, Joseph P. Milazzo, Herve Tiriac, Anna M. Kolarzyk, Esak Lee, Jean L. Grem, Audrey J. Lazenby, James A. Grunkemeyer, Michael A. Hollingsworth, Paul M. Grandgenett, Alexander D. Borowsky, Youngkyu Park, Christopher R. Vakoc, David A. Tuveson, Chang‐Il Hwang
Publikováno v:
Advanced Science, Vol 11, Iss 6, Pp n/a-n/a (2024)
Abstract Engrailed‐1 (EN1) is a critical homeodomain transcription factor (TF) required for neuronal survival, and EN1 expression has been shown to promote aggressive forms of triple negative breast cancer. Here, it is reported that EN1 is aberrant
Externí odkaz:
https://doaj.org/article/fa247bd53d254f95b68bf57810402255
Convection and extracellular matrix binding control interstitial transport of extracellular vesicles
Autor:
Peter A. Sariano, Rachel R. Mizenko, Venktesh S. Shirure, Abigail K. Brandt, Bryan B. Nguyen, Cem Nesiri, Bhupinder S. Shergill, Terza Brostoff, David M. Rocke, Alexander D. Borowsky, Randy P. Carney, Steven C. George
Publikováno v:
Journal of Extracellular Vesicles, Vol 12, Iss 4, Pp n/a-n/a (2023)
Abstract Extracellular vesicles (EVs) influence a host of normal and pathophysiological processes in vivo. Compared to soluble mediators, EVs can traffic a wide range of proteins on their surface including extracellular matrix (ECM) binding proteins,
Externí odkaz:
https://doaj.org/article/33101c8c7b304085b00e6da903cf7249
Autor:
Hong Wang, Qianqian Wang, Guodi Cai, Zhijian Duan, Zoann Nugent, Jie Huang, Jianwei Zheng, Alexander D. Borowsky, Jian Jian Li, Peiqing Liu, Hsing-Jien Kung, Leigh Murphy, Hong-Wu Chen, Junjian Wang
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 12, Iss 4, Pp 1871-1884 (2022)
Metabolic and epigenetic reprogramming play important roles in cancer therapeutic resistance. However, their interplays are poorly understood. We report here that elevated TIGAR (TP53-induced glycolysis and apoptosis regulator), an antioxidant and gl
Externí odkaz:
https://doaj.org/article/538925d98d464283b8a69c88387e94f7
Autor:
Jennifer Griessinger, Julian Schwab, Qian Chen, Anna Kühn, Jonathan Cotton, Gregory Bowden, Heike Preibsch, Gerald Reischl, Leticia Quintanilla-Martinez, Hidetoshi Mori, An Nguyen Dang, Ursula Kohlhofer, Olulanu H. Aina, Alexander D. Borowsky, Bernd J. Pichler, Robert D. Cardiff, Andreas M. Schmid
Publikováno v:
npj Breast Cancer, Vol 8, Iss 1, Pp 1-13 (2022)
Abstract The staging and local management of breast cancer involves the evaluation of the extent and completeness of excision of both the invasive carcinoma component and also the intraductal component or ductal carcinoma in situ. When both invasive
Externí odkaz:
https://doaj.org/article/ea7f74d102994bf0875ebadd686c5923
Autor:
Daniela Nachmanson, Adam Officer, Hidetoshi Mori, Jonathan Gordon, Mark F. Evans, Joseph Steward, Huazhen Yao, Thomas O’Keefe, Farnaz Hasteh, Gary S. Stein, Kristen Jepsen, Donald L. Weaver, Gillian L. Hirst, Brian L. Sprague, Laura J. Esserman, Alexander D. Borowsky, Janet L. Stein, Olivier Harismendy
Publikováno v:
npj Breast Cancer, Vol 8, Iss 1, Pp 1-13 (2022)
Abstract Microenvironmental and molecular factors mediating the progression of Breast Ductal Carcinoma In Situ (DCIS) are not well understood, impeding the development of prevention strategies and the safe testing of treatment de-escalation. We addre
Externí odkaz:
https://doaj.org/article/25a046ee37fb400db82cd80023557ef6
Autor:
Yash S. Huilgol, Holly Keane, Yiwey Shieh, Robert A. Hiatt, Jeffrey A. Tice, Lisa Madlensky, Leah Sabacan, Allison Stover Fiscalini, Elad Ziv, Irene Acerbi, Mandy Che, Hoda Anton-Culver, Alexander D. Borowsky, Sharon Hunt, Arash Naeim, Barbara A. Parker, Laura J. van ‘T Veer, Athena Breast Health Network Investigators and Advocate Partners, Laura J. Esserman
Publikováno v:
npj Breast Cancer, Vol 7, Iss 1, Pp 1-7 (2021)
Abstract Risk-reducing endocrine therapy use, though the benefit is validated, is extremely low. The FDA has approved tamoxifen and raloxifene for a 5-year Breast Cancer Risk Assessment Tool (BCRAT) risk ≥ 1.67%. We examined the threshold at which
Externí odkaz:
https://doaj.org/article/91eaf37ec54149658dd7d48f84d13d80
Autor:
Brett Z. Fite, James Wang, Aris J. Kare, Asaf Ilovitsh, Michael Chavez, Tali Ilovitsh, Nisi Zhang, Weiyu Chen, Elise Robinson, Hua Zhang, Azadeh Kheirolomoom, Matthew T. Silvestrini, Elizabeth S. Ingham, Lisa M. Mahakian, Sarah M. Tam, Ryan R. Davis, Clifford G. Tepper, Alexander D. Borowsky, Katherine W. Ferrara
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract High intensity focused ultrasound (HIFU) rapidly and non-invasively destroys tumor tissue. Here, we sought to assess the immunomodulatory effects of MR-guided HIFU and its combination with the innate immune agonist CpG and checkpoint inhibit
Externí odkaz:
https://doaj.org/article/3b05fd16d36d4a2eaa4db739670dbc41
Autor:
Mehdi Damaghi, Hidetoshi Mori, Samantha Byrne, Liping Xu, Tingan Chen, Joseph Johnson, Nathan D. Gallant, Andriy Marusyk, Alexander D. Borowsky, Robert J. Gillies
Publikováno v:
Evolutionary Applications, Vol 13, Iss 10, Pp 2689-2703 (2020)
Abstract Growing tumors are dynamic and nonlinear ecosystems, wherein cancer cells adapt to their local microenvironment, and these adaptations further modify the environment, inducing more changes. From nascent intraductal neoplasms to disseminated
Externí odkaz:
https://doaj.org/article/639b8642c53846b58ca97707abf5e0e4
Autor:
Daniela Nachmanson, Joseph Steward, Huazhen Yao, Adam Officer, Eliza Jeong, Thomas J. O’Keefe, Farnaz Hasteh, Kristen Jepsen, Gillian L. Hirst, Laura J. Esserman, Alexander D. Borowsky, Olivier Harismendy
Publikováno v:
BMC Medical Genomics, Vol 13, Iss 1, Pp 1-15 (2020)
Abstract Background Systematic cancer screening has led to the increased detection of pre-malignant lesions (PMLs). The absence of reliable prognostic markers has led mostly to over treatment resulting in potentially unnecessary stress, or insufficie
Externí odkaz:
https://doaj.org/article/1f9e00e7637c4021a342f7e36b39379a
Publikováno v:
Experimental and Molecular Medicine, Vol 52, Iss 4, Pp 538-547 (2020)
Cancer: Inflammatory enzyme linked to skin and esophageal tumors Drugs that block a pro-inflammatory enzyme implicated in cancer initiation and progression could help suppress the development of skin and esophageal cancers that arise from abnormal sq
Externí odkaz:
https://doaj.org/article/1e006bd90b4f418c8b2ad19d12b2d899