Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Alexander D, Barrow"'
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Externí odkaz:
https://doaj.org/article/16e1d5eda02f4f96aad26e98e964e647
Autor:
Ryan Hutchinson, Alexander D. Barrow, Yitong Fang, Samuel S Widodo, Stefano Mangiola, Christopher M. Hovens, Stanley S. Stylli, Theo Mantamadiotis, Marija Dinevska, Phillip K. Darcy, Paul J Neeson
Publikováno v:
Cancer Immunology, Immunotherapy. 70:1811-1820
Recent developments in cancer immunotherapy promise better outcomes for cancer patients, although clinical trials for difficult to treat cancers such as malignant brain cancer present special challenges, showing little response to first generation im
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Autor:
Yaseelan Palarasah, Alexander James Sedgwick, Abdullah-Al-Kamran Khan, Stefano Mangiola, Alexander D. Barrow, Yuhan Sun
Publikováno v:
Frontiers in Immunology
Sun, Y, Sedgwick, A J, Khan, M A-A-K, Palarasah, Y, Mangiola, S & Barrow, A D 2021, ' A Transcriptional Signature of IL-2 Expanded Natural Killer Cells Predicts More Favorable Prognosis in Bladder Cancer ', Frontiers in Immunology, vol. 12, 724107 . https://doi.org/10.3389/fimmu.2021.724107
Frontiers in Immunology, Vol 12 (2021)
Sun, Y, Sedgwick, A J, Khan, M A-A-K, Palarasah, Y, Mangiola, S & Barrow, A D 2021, ' A Transcriptional Signature of IL-2 Expanded Natural Killer Cells Predicts More Favorable Prognosis in Bladder Cancer ', Frontiers in Immunology, vol. 12, 724107 . https://doi.org/10.3389/fimmu.2021.724107
Frontiers in Immunology, Vol 12 (2021)
Activation of natural killer (NK) cell function is regulated by cytokines, such as IL-2, and secreted factors upregulated in the tumor microenvironment, such as platelet-derived growth factor D (PDGF-DD). In order to elucidate a clinical role for the
Autor:
Alexander D. Barrow, Yuhan Sun, Stefano Mangiola, Yaseelan Palarasah, Alexander James Sedgwick
Publikováno v:
Frontiers in Immunology
Frontiers in Immunology, Vol 12 (2021)
Sun, Y, Sedgwick, A J, Palarasah, Y & Mangiola, S 2021, ' A Transcriptional Signature of PDGF-DD Activated Natural Killer Cells Predicts More Favorable Prognosis in Low-Grade Glioma ', Frontiers in Immunology, vol. 12, 668391 . https://doi.org/10.3389/fimmu.2021.668391
Frontiers in Immunology, Vol 12 (2021)
Sun, Y, Sedgwick, A J, Palarasah, Y & Mangiola, S 2021, ' A Transcriptional Signature of PDGF-DD Activated Natural Killer Cells Predicts More Favorable Prognosis in Low-Grade Glioma ', Frontiers in Immunology, vol. 12, 668391 . https://doi.org/10.3389/fimmu.2021.668391
The binding of platelet-derived growth factor D (PDGF-DD) to the NKp44 receptor activates a distinct transcriptional program in primary IL-2 expanded human natural killer (NK) cells. We were interested in knowing if the PDGF-DD-NKp44 pathway of NK ce
Autor:
Huan Cao, John Elvin, Emma Gudgin, Andreas Neerincx, Brian J. P. Huntly, John Trowsdale, Bernard de Bono, Clare Pridans, Mark A. Vickers, Ursula Lakner, Catherine Huntington, Alexander D. Barrow
Publikováno v:
British journal of haematologyReferences. 193(5)
Sialic acid-binding immunoglobulin-like lectin (Siglec)-15 has recently been identified as a critical tumour checkpoint, augmenting the expression and function of programmed death-ligand 1. We raised a monoclonal antibody, A9E8, specific for Siglec-1
Autor:
Samuel S, Widodo, Ryan A, Hutchinson, Yitong, Fang, Stefano, Mangiola, Paul J, Neeson, Phillip K, Darcy, Alexander D, Barrow, Christopher M, Hovens, Marija, Dinevska, Stanley S, Stylli, Theo, Mantamadiotis
Publikováno v:
Cancer immunology, immunotherapy : CII. 70(7)
Recent developments in cancer immunotherapy promise better outcomes for cancer patients, although clinical trials for difficult to treat cancers such as malignant brain cancer present special challenges, showing little response to first generation im
Autor:
Robert A Eagle, Gillian Flack, Anthony Warford, Jesús Martínez-Borra, Insiya Jafferji, James A Traherne, Maki Ohashi, Louise H Boyle, Alexander D Barrow, Sophie Caillat-Zucman, Neil T Young, John Trowsdale
Publikováno v:
PLoS ONE, Vol 4, Iss 2, p e4503 (2009)
BackgroundThe activating immunoreceptor NKG2D is expressed on Natural Killer (NK) cells and subsets of T cells. NKG2D contributes to anti-tumour and anti-viral immune responses in vitro and in vivo. The ligands for NKG2D in humans are diverse protein
Externí odkaz:
https://doaj.org/article/fc713ba0efb440538c1dc3d4584813bd
Autor:
Robert A. Eagle, Gillian Flack, Anthony Warford, Jesús Martínez-Borra, Insiya Jafferji, James A. Traherne, Maki Ohashi, Louise H. Boyle, Alexander D. Barrow, Sophie Caillat-Zucman, Neil T. Young, John Trowsdale
Publikováno v:
PLoS ONE, Vol 4, Iss 3 (2009)
Externí odkaz:
https://doaj.org/article/f56eb3ea515b4f6daf938b3d384b283d
Autor:
Marco Colonna, Alexander D. Barrow
Publikováno v:
Seminars in Immunology. 31:30-36
Natural killer (NK) cells are cytotoxic and cytokine-secreting cells that can mediate potent anti-tumour activity. Accumulating evidence indicates that NK cell functions are severely compromised within the confines of the tumour microenvironment thus