Efficient generation of lower induced motor neurons by coupling Ngn2 expression with developmental cues

Autor: Francesco Limone, Irune Guerra San Juan, Jana M. Mitchell, Janell L.M. Smith, Kavya Raghunathan, Daniel Meyer, Sulagna Dia Ghosh, Alexander Couto, Joseph R. Klim, Brian J. Joseph, John Gold, Curtis J. Mello, James Nemesh, Brittany M. Smith, Matthijs Verhage, Steven A. McCarroll, Olli Pietiläinen, Ralda Nehme, Kevin Eggan

Publikováno v: Cell Reports, 42(1):111896, 1-21. Cell Press
Cell Reports, 42(1):111896. Cell Press
Limone, F, Guerra San Juan, I, Mitchell, J M, Smith, J L M, Raghunathan, K, Meyer, D, Ghosh, S D, Couto, A, Klim, J R, Joseph, B J, Gold, J, Mello, C J, Nemesh, J, Smith, B M, Verhage, M, McCarroll, S A, Pietiläinen, O, Nehme, R & Eggan, K 2023, ' Efficient generation of lower induced motor neurons by coupling Ngn2 expression with developmental cues ', Cell Reports, vol. 42, no. 1, 111896, pp. 1-21 . https://doi.org/10.1016/j.celrep.2022.111896
Limone, F, Guerra San Juan, I, Mitchell, J M, Smith, J L M, Raghunathan, K, Meyer, D, Ghosh, S D, Couto, A, Klim, J R, Joseph, B J, Gold, J, Mello, C J, Nemesh, J, Smith, B M, Verhage, M, McCarroll, S A, Pietiläinen, O, Nehme, R & Eggan, K 2023, ' Efficient generation of lower induced motor neurons by coupling Ngn2 expression with developmental cues ', Cell Reports, vol. 42, no. 1, 111896 . https://doi.org/10.1016/j.celrep.2022.111896

Human pluripotent stem cells (hPSCs) are a powerful tool for disease modeling of hard-to-access tissues (such as the brain). Current protocols either direct neuronal differentiation with small molecules or use transcription-factor-mediated programmin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20846473ea56d08b4a5ee688ff900315
http://hdl.handle.net/10138/357693

PIKFYVE inhibition mitigates disease in models of diverse forms of ALS

Autor: Shu-Ting Hung, Gabriel R. Linares, Wen-Hsuan Chang, Yunsun Eoh, Gopinath Krishnan, Stacee Mendonca, Sarah Hong, Yingxiao Shi, Manuel Santana, Chuol Kueth, Samantha Macklin-Isquierdo, Sarah Perry, Sarah Duhaime, Claudia Maios, Jonathan Chang, Joscany Perez, Alexander Couto, Jesse Lai, Yichen Li, Samuel V. Alworth, Eric Hendricks, Yaoming Wang, Berislav V. Zlokovic, Dion K. Dickman, J. Alex Parker, Daniela C. Zarnescu, Fen-Biao Gao, Justin K. Ichida

Publikováno v: Cell. 186:786-802.e28

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3bc0e2544e62c049ed95ead80120b6b2
https://doi.org/10.1016/j.cell.2023.01.005

Loss of mouse Stmn2 function causes motor neuropathy

Autor: Irune Guerra San Juan, Leslie A. Nash, Kevin S. Smith, Marcel F. Leyton-Jaimes, Menglu Qian, Joseph R. Klim, Francesco Limone, Alexander B. Dorr, Alexander Couto, Greta Pintacuda, Brian J. Joseph, D. Eric Whisenant, Caroline Noble, Veronika Melnik, Deirdre Potter, Amie Holmes, Aaron Burberry, Matthijs Verhage, Kevin Eggan

Publikováno v: Neuron
Neuron, 110(10), 1671-1688.e6. Cell Press
Guerra San Juan, I, Nash, L A, Smith, K S, Leyton-Jaimes, M F, Qian, M, Klim, J R, Limone, F, Dorr, A B, Couto, A, Pintacuda, G, Joseph, B J, Whisenant, D E, Noble, C, Melnik, V, Potter, D, Holmes, A, Burberry, A, Verhage, M & Eggan, K 2022, ' Loss of mouse Stmn2 function causes motor neuropathy ', Neuron, vol. 110, no. 10, pp. 1671-1688.e6 . https://doi.org/10.1016/j.neuron.2022.02.011

Amyotrophic lateral sclerosis (ALS) is characterized by motor neuron degeneration accompanied by aberrant accumulation and loss of function of the RNA-binding protein TDP43. Thus far, it remains unresolved to what extent TDP43 loss of function direct

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74f8b793528a00714433808ce22c13f6
https://doi.org/10.1016/j.neuron.2022.02.011

Em busca da nação : ação coletiva nos ensaios de Oliveira Vianna e Caio Prado Jr.

Autor: Alexander Couto Englander

Este livro contribui para o debate sobre o tema da ação coletiva no pensamento social brasileiro a partir da comparação de três ensaios de interpretação nacional: Populações meridionais do Brasil (1920), de Oliveira Vianna (1883-1951), Evolu