Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Alexander Coulton"'
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract The paradigm for macrophage characterization has evolved from the simple M1/M2 dichotomy to a more complex model that encompasses the broad spectrum of macrophage phenotypic diversity, due to differences in ontogeny and/or local stimuli. We
Externí odkaz:
https://doaj.org/article/269cfff46f0a40a6876c6588d0c9c2bc
Autor:
Alexander Coulton, Keith J. Edwards
Publikováno v:
BMC Bioinformatics, Vol 21, Iss 1, Pp 1-8 (2020)
Abstract Background Polyploid organisms such as wheat complicate even the simplest of procedures in molecular biology. Whilst knowledge of genomic sequences in crops is increasing rapidly, the scientific community is still a long way from producing a
Externí odkaz:
https://doaj.org/article/71b3cc3b12c9496bbb0a89a7d3fd716c
Publikováno v:
Frontiers in Plant Science, Vol 11 (2020)
Meiotic recombination plays a crucial role in the generation of new varieties. The effectiveness of recombination is limited by the distribution of crossover events, which in wheat and many other crops is skewed toward the distal regions of the chrom
Externí odkaz:
https://doaj.org/article/77be6033b9f34b09ad84d6ddb1ce1d39
Autor:
Alexander Coulton, Alexandra M Przewieslik-Allen, Amanda J Burridge, Daniel S Shaw, Keith J Edwards, Gary L A Barker
Publikováno v:
PLoS ONE, Vol 15, Iss 2, p e0228951 (2020)
Segregation distortion is the phenomenon in which genotypes deviate from expected Mendelian ratios in the progeny of a cross between two varieties or species. There is not currently a widely used consensus for the appropriate statistical test, or mor
Externí odkaz:
https://doaj.org/article/bf45a40d6d1741678ec3f40569e9ec18
Autor:
Samra Turajlic, Mariam Jamal-Hanjani, Charles Swanton, Kevin Litchfield, James Larkin, Anna Green, Ula Mahadeva, Ruby Stewart, Lisa Pickering, Andrew J.S. Furness, Kate Young, Emma L. Nye, Gordon W.H. Stamp, Ian Proctor, Mary Falzon, David A. Moore, Miriam Mitchison, Elaine Borg, Cristina Naceur-Lombardelli, Jun Murai, Maise Al Bakir, Nicholas McGranahan, Ariana Huebner, Hang Xu, Aljosja Rogiers, Robert Mason, Joanna Lynch, Husayn Ahmed Pallikonda, Camille L. Gerard, Max Emmerich, Anne-Laure Cattin, Molly O'Flaherty, Charlotte Lewis, Justine Korteweg, Aida Murra, Jennifer Biano, Denise Kelly, Lauren Terry, Mary Mangwende, Sarah Vaughan, Sarah Sarker, Kayleigh Kelly, Kema Peat, Lauren Grostate, Karla Lingard, Zayd Tippu, Andreas M. Schmitt, Charlotte Spencer, Diana C.J. Spierings, Rene Wardenaar, Hilda van den Bos, Floris Foijer, Jaime Nobbs, Peta Hughes, Christina Messiou, Alexandra Renn, Nikki Hunter, Eleanor Carlyle, Kim Edmonds, Lewis Au, Elisa Piperni, Maria Goicoechea, Fiona Byrne, Benjamin Shum, Scott T.C. Shepherd, Desiree Schnidrig, Andrew Rowan, Irene Lobon, Alexander Coulton, Lavinia Spain
Understanding the evolutionary pathways to metastasis and resistance to immune-checkpoint inhibitors (ICI) in melanoma is critical for improving outcomes. Here, we present the most comprehensive intrapatient metastatic melanoma dataset assembled to d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::682740b5baa2c65d53e95cea4595dfad
https://doi.org/10.1158/2159-8290.c.6649132
https://doi.org/10.1158/2159-8290.c.6649132
Autor:
Samra Turajlic, Mariam Jamal-Hanjani, Charles Swanton, Kevin Litchfield, James Larkin, Anna Green, Ula Mahadeva, Ruby Stewart, Lisa Pickering, Andrew J.S. Furness, Kate Young, Emma L. Nye, Gordon W.H. Stamp, Ian Proctor, Mary Falzon, David A. Moore, Miriam Mitchison, Elaine Borg, Cristina Naceur-Lombardelli, Jun Murai, Maise Al Bakir, Nicholas McGranahan, Ariana Huebner, Hang Xu, Aljosja Rogiers, Robert Mason, Joanna Lynch, Husayn Ahmed Pallikonda, Camille L. Gerard, Max Emmerich, Anne-Laure Cattin, Molly O'Flaherty, Charlotte Lewis, Justine Korteweg, Aida Murra, Jennifer Biano, Denise Kelly, Lauren Terry, Mary Mangwende, Sarah Vaughan, Sarah Sarker, Kayleigh Kelly, Kema Peat, Lauren Grostate, Karla Lingard, Zayd Tippu, Andreas M. Schmitt, Charlotte Spencer, Diana C.J. Spierings, Rene Wardenaar, Hilda van den Bos, Floris Foijer, Jaime Nobbs, Peta Hughes, Christina Messiou, Alexandra Renn, Nikki Hunter, Eleanor Carlyle, Kim Edmonds, Lewis Au, Elisa Piperni, Maria Goicoechea, Fiona Byrne, Benjamin Shum, Scott T.C. Shepherd, Desiree Schnidrig, Andrew Rowan, Irene Lobon, Alexander Coulton, Lavinia Spain
Supplementary figure 1: Cohort overview. Number of samples sequenced with whole exome, panel or whole RNA sequencing. Supplementary figure 2: Phylogeny and WGD events in CRUKP1047. Supplementary figure 3: Ploidy and SCNA burden. Supplementary figure
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f79ce57c107fe296590c39e19d1d2e6
https://doi.org/10.1158/2159-8290.22841335.v1
https://doi.org/10.1158/2159-8290.22841335.v1
Autor:
Samra Turajlic, Mariam Jamal-Hanjani, Charles Swanton, Kevin Litchfield, James Larkin, Anna Green, Ula Mahadeva, Ruby Stewart, Lisa Pickering, Andrew J.S. Furness, Kate Young, Emma L. Nye, Gordon W.H. Stamp, Ian Proctor, Mary Falzon, David A. Moore, Miriam Mitchison, Elaine Borg, Cristina Naceur-Lombardelli, Jun Murai, Maise Al Bakir, Nicholas McGranahan, Ariana Huebner, Hang Xu, Aljosja Rogiers, Robert Mason, Joanna Lynch, Husayn Ahmed Pallikonda, Camille L. Gerard, Max Emmerich, Anne-Laure Cattin, Molly O'Flaherty, Charlotte Lewis, Justine Korteweg, Aida Murra, Jennifer Biano, Denise Kelly, Lauren Terry, Mary Mangwende, Sarah Vaughan, Sarah Sarker, Kayleigh Kelly, Kema Peat, Lauren Grostate, Karla Lingard, Zayd Tippu, Andreas M. Schmitt, Charlotte Spencer, Diana C.J. Spierings, Rene Wardenaar, Hilda van den Bos, Floris Foijer, Jaime Nobbs, Peta Hughes, Christina Messiou, Alexandra Renn, Nikki Hunter, Eleanor Carlyle, Kim Edmonds, Lewis Au, Elisa Piperni, Maria Goicoechea, Fiona Byrne, Benjamin Shum, Scott T.C. Shepherd, Desiree Schnidrig, Andrew Rowan, Irene Lobon, Alexander Coulton, Lavinia Spain
S. Table 1: List of PEACE Consortium members. S. Table 2: Sample database used for the study for Panel, Exome and RNASeq samples. S. Table 3: Overview of lines of treatment given to each patient. S. Table 4: Lesions and patients included in the lesio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33ff6cf95efc3203d7876d1cbdc0ba2e
https://doi.org/10.1158/2159-8290.22841332
https://doi.org/10.1158/2159-8290.22841332
Autor:
Lavinia Spain, Alexander Coulton, Irene Lobon, Andrew Rowan, Desiree Schnidrig, Kevin Litchfield, Charles Swanton, Mariam Jamal-Hanjani, Samra Turajlic
Understanding the evolutionary pathways to metastasis and resistance to immune checkpoint inhibitors (ICI) in melanoma is critical for improving outcomes. Here we present the most comprehensive intra-patient metastatic melanoma dataset assembled to d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a63b8c69ab86588b6a8fe0be75f4e328
Autor:
Alexander Coulton, Samra Turajlic
Publikováno v:
Cancer Cell. 40:134-135
Autor:
Alexander Coulton, Irene Lobon, Lavinia Spain, Andrew Rowan, Desiree Shnidrig, Scott Shepherd, Ben Shum, Fiona Byrne, Lewis Au, Kim Edmonds, Ellie Carlyle, Alexandra Renn, Christina Messiou, Charlotte Spencer, Andreas M. Schmidt, Zayd Tippu, Aljosja Rogiers, Max Emmerich, Camille Gerard, Husayn Pallikonda, Cristina Naceur-Lombardelli, Floris Foijer, Hilda van den Bos, René Wardenaar, Diana Spierings, Kate Young, Lisa Pickering, Andrew Furness, Elaine Borg, Miriam Mitchison, David Moore, Mary Falzon, Ian Proctor, Ruby Stewart, Ula Mahadeva, Anna Green, James Larkin, Charles Swanton, Mariam Jamal-Hanjani, Kevin Litchfield, Samra Turajlic
Publikováno v:
Cancer Research. 82:A012-A012
This abstract is being presented as a short talk in the scientific program. A full abstract is available in the Proffered Abstracts section (PR002) of the Conference Proceedings. Citation Format: Alexander Coulton, Irene Lobon, Lavinia Spain, Andrew