Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Alexander Colbert"'
Autor:
Mallory Kato, Lawrence Tang, Quan Lam, David B. Goodin, Jessica N. Spradlin, Diana Lee, Sruthi Mahadevan, Oliver S. Shafaat, Lionel Cheruzel, Alexander Colbert, Mavish Mahomed, Marco Kloos
Publikováno v:
Biochimica et Biophysica Acta
Biochimica et biophysica acta, vol 1864, iss 12
Biochimica et biophysica acta, vol 1864, iss 12
Background: In order to perform selective C-H functionalization upon visible light irradiation, Ru(II)-diimine functionalized P450 heme enzymes have been developed. The sL407C-1 enzyme containing the Ru(bpy)_2PhenA (bpy = 2,2′-bipyridine and PhenA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a05cbcacaaa99c1986419fc8efcd08a8
https://doi.org/10.1016/j.bbapap.2016.09.005
https://doi.org/10.1016/j.bbapap.2016.09.005
Autor:
Vincent Chow, Marta Starcevic Manning, Sarah A Hoofring, J Miller, Gary Fanjiang, Alexander Colbert, Melissa A. Gessner, Dan Mytych
Publikováno v:
Diagnostics and imaging procedures.
Background Adalimumab and its biosimilars are anti-tumour necrosis factor (TNF)- monoclonal antibodies that are approved in Europe as treatment for various autoimmune-related indications, including Crohn’s disease and ulcerative colitis. Despite th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2a9e0d6301729e3a3ab740aadfe08eae
https://doi.org/10.1136/annrheumdis-2019-eular.6361
https://doi.org/10.1136/annrheumdis-2019-eular.6361
Autor:
Sabina Buntich, Amber Umble-Romero, Wei-Jian Pan, L Som, Jason M. Gow, C D Krill, Yu Sun, Samantha P. Prokop, Kathleen Köck, Alexander Colbert, Yu Zhang, Wayne Tsuji, Jennifer E. Towne, T J Goletz, M W Trimble, William A. Rees, John P. Gibbs, Michelle Horner, J C O'Neill, Kathryn J. Newhall
Publikováno v:
British Journal of Pharmacology. 172:159-172
Background and Purpose AMG 139 is a human anti-IL-23 antibody currently in a phase II trial for treating Crohn's disease. To support its clinical development in humans, in vitro assays and in vivo studies were conducted in cynomolgus monkeys to deter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ff2df1ca4f60b9725b1651875f7c7b2d
https://doi.org/10.1111/bph.12904
https://doi.org/10.1111/bph.12904
Publikováno v:
Inorganic chemistry. 56(11)
Ru(II)-diimine complexes covalently attached near the heme active site of P450 BM3 enzymes have been used to rapidly inject electrons and drive selective C-H functionalization upon visible light irradiation. Herein, we have generated a series of hybr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92db0ab2e05da7d52cad0fa3fba9a930
https://pubmed.ncbi.nlm.nih.gov/28537742
https://pubmed.ncbi.nlm.nih.gov/28537742
Autor:
John P. Gibbs, Susan Pederson, Alexander Colbert, Amber Umble-Romero, Samantha P. Prokop, Ren Xu
Publikováno v:
mAbs
Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a serine protease that plays an important role in the regulation of serum low-density lipoprotein (LDL) cholesterol by downregulation of LDL receptor, and as such is considered a novel target i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::918032aab5ead36d9f8843434e46507e
https://doi.org/10.4161/mabs.28719
https://doi.org/10.4161/mabs.28719
Autor:
Stephen Uy, Brian Smith, Evan A. Stein, Scott M. Wasserman, Caroline Crispino, Clapton Dias, Alexander Colbert, Marc W. Retter, Mark Matson, Blaire Cooke, Maurice Emery, Adam J. Shaywitz, John P. Gibbs, Dina Stolman, Karen Smirnakis, Bing Gao
Publikováno v:
Journal of the American College of Cardiology. 60:1888-1898
Objectives: The aim of this study was to evaluate the safety, tolerability, and effects of AMG 145 on low-density lipoprotein cholesterol (LDL-C) in healthy and hypercholesterolemic subjects on sta...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4a19f02051ae29e12bb63e2b6bf6571
https://doi.org/10.1016/j.jacc.2012.08.986
https://doi.org/10.1016/j.jacc.2012.08.986
Autor:
Alejandro Cortez, Alexander Colbert, Sudharsan Dwaraknath, Angelina Nguyen, Sarah Mullen, Thanh Dao, Lionel Cheruzel, Ngoc-Han Tran
We have synthesized and characterized four octahedral polypyridyl d(6) metal complexes bearing the 5,6-epoxy-5,6-dihydro-[1,10]phenanthroline ligand (L1) as cysteine specific labeling reagents. The proposed synthetic pathways allow the preparation of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64357ce64669d2833b068d5e70319694
https://europepmc.org/articles/PMC4058400/
https://europepmc.org/articles/PMC4058400/
Autor:
Clapton S, Dias, Adam J, Shaywitz, Scott M, Wasserman, Brian P, Smith, Bing, Gao, Dina S, Stolman, Caroline P, Crispino, Karen V, Smirnakis, Maurice G, Emery, Alexander, Colbert, John P, Gibbs, Marc W, Retter, Blaire P, Cooke, Stephen T, Uy, Mark, Matson, Evan A, Stein
Publikováno v:
Journal of the American College of Cardiology. 60(19)
The aim of this study was to evaluate the safety, tolerability, and effects of AMG 145 on low-density lipoprotein cholesterol (LDL-C) in healthy and hypercholesterolemic subjects on statin therapy.Proprotein convertase subtilisin/kexin type 9 (PCSK9)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::594da8e2f2af49190f935c3583baad4b
https://pubmed.ncbi.nlm.nih.gov/23083772
https://pubmed.ncbi.nlm.nih.gov/23083772
Autor:
Stephen Uy, Caroline Crispino, Bing Gao, Scott M. Wasserman, Karen Smirnakis, Ren Xu, Mark Matson, Dina Stolman, Blaire Cooke, Maurice Emery, Clapton Dias, Adam J. Shaywitz, Brian H. Smith, Marc W. Retter, Evan A. Stein, Alexander Colbert, John P. Gibbs
Publikováno v:
Journal of Clinical Lipidology. 6:286-287
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::30fa4869dbdfded72ee78d979e9ad586
https://doi.org/10.1016/j.jacl.2012.04.066
https://doi.org/10.1016/j.jacl.2012.04.066