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pro vyhledávání: '"Alexander Chu-Kung"'
Autor:
Michael J. Rozema, Brian J. Kotecki, Albert W. Kruger, Anthony R. Haight, Albert M. Schwartz, Zhe Wang, Steven M. Richter, Alexander Chu-Kung, Jorge Gandarilla
Publikováno v:
Organic Process Research & Development. 13:1419-1425
The discovery, development and implementation of two chemical routes to ABT-869 is reported. Optimization of the first-generation heterocycle formation and Suzuki coupling is briefly described. Key features of the second-generation synthesis include