Zobrazeno 1 - 10
of 73
pro vyhledávání: '"Alexander C. Drohat"'
Autor:
Brittani L. Schnable, Matthew A. Schaich, Vera Roginskaya, Liam P. Leary, Tyler M. Weaver, Bret D. Freudenthal, Alexander C. Drohat, Bennett Van Houten
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)
Abstract Base excision repair is the main pathway involved in active DNA demethylation. 5-formylcytosine and 5-carboxylcytosine, two oxidized moieties of methylated cytosine, are recognized and removed by thymine DNA glycosylase (TDG) to generate an
Externí odkaz:
https://doaj.org/article/c5ab3255991842278bb091539a39a8ac
Autor:
Lakshmi S. Pidugu, Hardler W. Servius, Spiridon E. Sevdalis, Mary E. Cook, Kristen M. Varney, Edwin Pozharski, Alexander C. Drohat
Publikováno v:
PLoS ONE, Vol 18, Iss 1 (2023)
AP endonuclease 1 (APE1) processes DNA lesions including apurinic/apyrimidinic sites and 3´-blocking groups, mediating base excision repair and single strand break repair. Much effort has focused on developing specific inhibitors of APE1, which coul
Externí odkaz:
https://doaj.org/article/32eae5cb6764407b9dcf845b634d46d6
Publikováno v:
Biophysical Journal. 122:355a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fe4e55cca9e3608cedbf18e2b553682c
https://doi.org/10.1016/j.bpj.2022.11.1967
https://doi.org/10.1016/j.bpj.2022.11.1967
Publikováno v:
Journal of Biological Chemistry. 299:102756
Oxidation of DNA bases generates mutagenic and cytotoxic lesions that are implicated in cancer and other diseases. Oxidative base lesions, including 7,8-dihydro-8-oxoguanine (oxoG), are typically removed through base excision repair (BER). In additio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e24d899350618513706e22448fd67096
https://doi.org/10.1016/j.jbc.2022.102756
https://doi.org/10.1016/j.jbc.2022.102756
Publikováno v:
Journal of the American Chemical Society. 141:4952-4962
A broad range of proteins employ nucleotide flipping to recognize specific sites in nucleic acids, including DNA glycosylases, which remove modified nucleobases to initiate base excision repair. Deamination, a pervasive mode of damage, typically gene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3c1202b6dee708412f032edd9cb532e9
https://doi.org/10.1021/jacs.9b00146
https://doi.org/10.1021/jacs.9b00146
Autor:
Jennifer L Illuzzi, Nicole A Harris, Brittney A Manvilla, Daemyung Kim, Mengxia Li, Alexander C Drohat, David M Wilson
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e65922 (2013)
Apurinic/apyrimidinic endonuclease 1 (APE1) is the predominant AP site repair enzyme in mammals. APE1 also maintains 3'-5' exonuclease and 3'-repair activities, and regulates transcription factor DNA binding through its REF-1 function. Since complete
Externí odkaz:
https://doaj.org/article/ca95f19d63ee4dd6bcc755cc748ad470
Publikováno v:
Nucleic Acids Research
Thymine DNA glycosylase (TDG) excises thymine from mutagenic G·T mispairs generated by deamination of 5-methylcytosine (mC) and it removes two mC derivatives, 5−formylcytosine (fC) and 5−carboxylcytosine (caC), in a multistep pathway for DNA dem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acc5c3b4660ed8bb279fffb767277444
http://europepmc.org/articles/PMC6007377
http://europepmc.org/articles/PMC6007377
Autor:
Edwin Pozharski, Sheila S. David, Alexander C. Drohat, Robert P. Van Ostrand, Hilary Bright, Wen-Jen Lin, Chandrima Majumdar, Lakshmi S. Pidugu
Publikováno v:
Journal of molecular biology, vol 433, iss 15
J Mol Biol
J Mol Biol
DNA glycosylases remove damaged or modified nucleobases by cleaving the N-glycosyl bond and the correct nucleotide is restored through subsequent base excision repair. In addition to excising threatening lesions, DNA glycosylases contribute to epigen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::031bc9e02c561492fafc568b41ab5546
https://doi.org/10.1016/j.jmb.2021.167097
https://doi.org/10.1016/j.jmb.2021.167097
Publikováno v:
J Am Chem Soc
5-Methylcytosine (mC) is an epigenetic mark that is written by methyltransferases, erased through passive and active mechanisms, and impacts transcription, development, diseases including cancer, and aging. Active DNA demethylation involves TET-media
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e827cff9d983bb43a4ef4dbc7860ae23
https://pubmed.ncbi.nlm.nih.gov/31693361
https://pubmed.ncbi.nlm.nih.gov/31693361
Publikováno v:
Journal of the American Chemical Society. 141(12)
A broad range of proteins employ nucleotide flipping to recognize specific sites in nucleic acids, including DNA glycosylases, which remove modified nucleobases to initiate base excision repair. Deamination, a pervasive mode of damage, typically gene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d77dd1d50de83b268a0f1a6184e8911c
https://pubmed.ncbi.nlm.nih.gov/30841696
https://pubmed.ncbi.nlm.nih.gov/30841696