Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Alexander C. Brueckner"'
Publikováno v:
Journal of Medicinal Chemistry. 66:1955-1971
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fbcb5bf80b2c763f1e696cc744337efa
https://doi.org/10.1021/acs.jmedchem.2c01744
https://doi.org/10.1021/acs.jmedchem.2c01744
Autor:
Simon Ng, Alexander C. Brueckner, Soheila Bahmanjah, Qiaolin Deng, Jennifer M. Johnston, Lan Ge, Ruchia Duggal, Bahanu Habulihaz, Benjamin Barlock, Sookhee Ha, Ahmad Sadruddin, Constance Yeo, Corey Strickland, Andrea Peier, Brian Henry, Edward C. Sherer, Anthony W. Partridge
Publikováno v:
Journal of Medicinal Chemistry. 65:9789-9801
STIP1 homology and U-Box containing protein 1 (STUB1) plays a key role in maintaining cell health during stress and aging. Recent evidence suggested STUB1 also helps regulate immunity with the potential of clearing malignant cells. Indeed, we and oth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82d4ec6db56ddbda74bf2aedff793236
https://doi.org/10.1021/acs.jmedchem.2c00406
https://doi.org/10.1021/acs.jmedchem.2c00406
Autor:
Alexander C. Brueckner, Ann E. Cleves, Edward C. Sherer, Qiaolin Deng, Mikhail Reibarkh, Ajay N. Jain, Charles A. Lesburg, Juan C. Alvarez
Publikováno v:
Journal of Medicinal Chemistry. 64:3282-3298
Macrocyclic peptides are an important modality in drug discovery, but molecular design is limited due to the complexity of their conformational landscape. To better understand conformational propensities, global strain energies were estimated for 156
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42213055d2f2991f2d1c48c5b3fdf836
https://doi.org/10.1021/acs.jmedchem.0c02159
https://doi.org/10.1021/acs.jmedchem.0c02159
Autor:
Charles A. Lesburg, Alexander C. Brueckner, Qiaolin Deng, Ann E. Cleves, Edward C. Sherer, Mikhail Reibarkh, Ajay N. Jain
Publikováno v:
Journal of Medicinal Chemistry. 63:10509-10528
We report a new method for X-ray density ligand fitting and refinement that is suitable for a wide variety of small-molecule ligands, including macrocycles. The approach (called "xGen") augments a force field energy calculation with an electron densi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de61ef0c116f6c0ccb929b0da9c853df
https://doi.org/10.1021/acs.jmedchem.0c01373
https://doi.org/10.1021/acs.jmedchem.0c01373
Autor:
Ryan A. Altman, Taisiia Feoktistova, Manikandan Selvaraju, Paul Ha-Yeon Cheong, Ming-Hsiu Yang, Alexander C. Brueckner, Markas A. Grove, Suvajit Koley, Francisco de Azambuja
Publikováno v:
Nature chemistry
Transition metal-catalyzed C–H functionalization and decarboxylative coupling are two of the most notable synthetic strategies developed in the last 30 years. Herein, we connect these two reaction pathways using bases and a simple Pd-based catalyst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5f497bff9be334a04cd8532d278105f
https://doi.org/10.1038/s41557-020-0428-1
https://doi.org/10.1038/s41557-020-0428-1
Autor:
Mark A. Maskeri, Karl A. Scheidt, Daniel M. Walden, Taisiia Feoktistova, Matthew J. O'Connor, Alexander C. Brueckner, Paul Ha-Yeon Cheong
Publikováno v:
Chemical Science
Enantioselective additions to oxocarbenium ions are high-value synthetic transformations but have proven challenging to achieve. In particular, the oxa-Pictet–Spengler reaction has only recently been rendered enantioselective. We report experimenta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04434603607d706198a8df76e60b49ca
https://pubmed.ncbi.nlm.nih.gov/34123127
https://pubmed.ncbi.nlm.nih.gov/34123127
Publikováno v:
The Journal of Organic Chemistry. 84:9196-9214
The development of a π-stacking-based approach for increased stereoselectivity in Sharpless asymmetric and diastereomeric dihydroxylation of cis-enynes is disclosed. The use of neighboring, electron-rich benzoate esters proved key to the success of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3103beafdb08cc8812de8905a0334fe5
https://doi.org/10.1021/acs.joc.9b01153
https://doi.org/10.1021/acs.joc.9b01153
Autor:
Daniel M. Walden, Alexander C. Brueckner, Andrew D. Smith, Andrew D. Campbell, Taisiia Feoktistova, Markas A. Grove, Elizabeth S. Munday, Alexandra M. Z. Slawin, Claire M. Young, Paul Ha-Yeon Cheong
Publikováno v:
Angewandte Chemie (International ed. in English). 59(20)
We would like to thank the Engineering and Physical Sciences Research Council, University of St Andrews, and the EPSRC Centre for Doctoral Training in Critical Resource Catalysis (CRITICAT) for financial support [Ph.D. studentship to E.M.; Grant code
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da972dfb569c9bc9dd5fb7a99020b35e
https://pubmed.ncbi.nlm.nih.gov/31975528
https://pubmed.ncbi.nlm.nih.gov/31975528
Autor:
Alexander C. Brueckner, Paul Ha-Yeon Cheong, Karl A. Scheidt, H. Camille Richardson, Keegan P. Fitzpatrick, C. Benjamin Schwamb
Publikováno v:
Journal of the American Chemical Society. 140:10644-10648
The first highly selective catalytic hydroboration of alkyl-substituted aldimines to provide medicinally relevant α-amidoboronates is disclosed. The Cu(I)-catalyzed borylation proceeds with excellent facial selectivity when a set of planar-chiral N-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::662cf6d46c074bc78664e481b930ddc4
https://doi.org/10.1021/jacs.8b05045
https://doi.org/10.1021/jacs.8b05045
Autor:
Lisa M. Eytel, Alexander C. Brueckner, Jessica A. Lohrman, Michael M. Haley, Paul H.-Y. Cheong, Darren W. Johnson
Publikováno v:
Chemical Communications. 54:13208-13211
Conformationally flexible hosts with relatively small binding pockets are seldom shown to bind oxoanions preferentially over other guests. Herein, we disclose the binding of diprotic, monoprotic, and aprotic tetrahedral oxoanions with three different
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2606baa2b1ffbf872fc4e9981f9f64e1
https://doi.org/10.1039/c8cc07301e
https://doi.org/10.1039/c8cc07301e