Multi-omics approach identifies germline regulatory variants associated with hematopoietic malignancies in retriever dog breeds.

Autor: Jacquelyn M Evans, Heidi G Parker, Gerard R Rutteman, Jocelyn Plassais, Guy C M Grinwis, Alexander C Harris, Susan E Lana, Elaine A Ostrander

Publikováno v: PLoS Genetics, Vol 17, Iss 5, p e1009543 (2021)

Histiocytic sarcoma is an aggressive hematopoietic malignancy of mature tissue histiocytes with a poorly understood etiology in humans. A histologically and clinically similar counterpart affects flat-coated retrievers (FCRs) at unusually high freque

Externí odkaz: https://doaj.org/article/fc74da61633c453ea21758503fc0d908

Genome sequencing of 2000 canids by the Dog10K consortium advances the understanding of demography, genome function and architecture

Autor: Jennifer R. S. Meadows, Jeffrey M. Kidd, Guo-Dong Wang, Heidi G. Parker, Peter Z. Schall, Matteo Bianchi, Matthew J. Christmas, Katia Bougiouri, Reuben M. Buckley, Christophe Hitte, Anthony K. Nguyen, Chao Wang, Vidhya Jagannathan, Julia E. Niskanen, Laurent A. F. Frantz, Meharji Arumilli, Sruthi Hundi, Kerstin Lindblad-Toh, Catarina Ginja, Kadek Karang Agustina, Catherine André, Adam R. Boyko, Brian W. Davis, Michaela Drögemüller, Xin-Yao Feng, Konstantinos Gkagkavouzis, Giorgos Iliopoulos, Alexander C. Harris, Marjo K. Hytönen, Daniela C. Kalthoff, Yan-Hu Liu, Petros Lymberakis, Nikolaos Poulakakis, Ana Elisabete Pires, Fernando Racimo, Fabian Ramos-Almodovar, Peter Savolainen, Semina Venetsani, Imke Tammen, Alexandros Triantafyllidis, Bridgett vonHoldt, Robert K. Wayne, Greger Larson, Frank W. Nicholas, Hannes Lohi, Tosso Leeb, Ya-Ping Zhang, Elaine A. Ostrander

Publikováno v: Genome Biology, Vol 24, Iss 1, Pp 1-41 (2023)

Abstract Background The international Dog10K project aims to sequence and analyze several thousand canine genomes. Incorporating 20 × data from 1987 individuals, including 1611 dogs (321 breeds), 309 village dogs, 63 wolves, and four coyotes, we ide

Externí odkaz: https://doaj.org/article/070c928591184511adb6d4a61799d1db

Genomic Diversity and Runs of Homozygosity in Bernese Mountain Dogs

Autor: Anna Letko, Benoît Hédan, Anna Snell, Alexander C. Harris, Vidhya Jagannathan, Göran Andersson, Bodil S. Holst, Elaine A. Ostrander, Pascale Quignon, Catherine André, Tosso Leeb

Publikováno v: Genes
Genes, 2023, 14 (3), ⟨10.3390/genes14030650⟩
Volume 14
Issue 3
Pages: 650
Letko, Anna; Hédan, Benoît; Snell, Anna; Harris, Alexander C; Jagannathan, Vidhya; Andersson, Göran; Holst, Bodil S; Ostrander, Elaine A; Quignon, Pascale; André, Catherine; Leeb, Tosso (2023). Genomic Diversity and Runs of Homozygosity in Bernese Mountain Dogs. Genes, 14(3) MDPI, Molecular Diversity Preservation International 10.3390/genes14030650

International audience; Bernese mountain dogs are a large dog breed formed in the early 1900s in Switzerland. While originally farm dogs that were used for pulling carts, guarding, and driving cattle, today they are considered multi-purpose companion

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf989161125248b224457090adcd5c91
https://hal.science/hal-04100178