Výsledky vyhledávání - "Alexander Bulgak"

Akademický článek

A novel bifunctional hybrid with marine bacterium alkaline phosphatase and Far Eastern holothurian mannan-binding lectin activities.

Autor: Larissa Balabanova, Vasily Golotin, Svetlana Kovalchuk, Alexander Bulgakov, Galina Likhatskaya, Oksana Son, Valery Rasskazov

Publikováno v: PLoS ONE, Vol 9, Iss 11, p e112729 (2014)

A fusion between the genes encoding the marine bacterium Cobetia marina alkaline phosphatase (CmAP) and Far Eastern holothurian Apostichopus japonicus mannan-binding C-type lectin (MBL-AJ) was performed. Expression of the fusion gene in E. coli cells

Externí odkaz: https://doaj.org/article/32555e6923d14a97992c68c591a6d621

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Prediction and modeling of effects on the QTc interval for clinical safety margin assessment, based on single-ascending-dose study data with AZD3839

Autor: Karin Tunblad, Robert Alexander, Angelica Quartino, Ahmad Al-Saffar, Jens Kågström, Michael D. B. Swedberg, Torbjorn Vik, Maria Lüttgen, Erik Sparve, Linnea Sjödin, Anna Teiling Gårdlund, Matthew Bridgland-Taylor, Alexander Bulgak, Johanna Fälting, Björn Paulsson, Chris Pollard

Publikováno v: The Journal of pharmacology and experimental therapeutics. 350(2)

Corrected QT interval (QTc) prolongation in humans is usually predictable based on results from preclinical findings. This study confirms the signal from preclinical cardiac repolarization models (human ether-a-go-go-related gene, guinea pig monophas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa6cdbb627717e61544155d5a6ff1f80
https://pubmed.ncbi.nlm.nih.gov/24917547

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