Výsledky vyhledávání - "Alexander Bulgak"

Prediction and modeling of effects on the QTc interval for clinical safety margin assessment, based on single-ascending-dose study data with AZD3839

Autor: Karin Tunblad, Robert Alexander, Angelica Quartino, Ahmad Al-Saffar, Jens Kågström, Michael D. B. Swedberg, Torbjorn Vik, Maria Lüttgen, Erik Sparve, Linnea Sjödin, Anna Teiling Gårdlund, Matthew Bridgland-Taylor, Alexander Bulgak, Johanna Fälting, Björn Paulsson, Chris Pollard

Publikováno v: The Journal of pharmacology and experimental therapeutics. 350(2)

Corrected QT interval (QTc) prolongation in humans is usually predictable based on results from preclinical findings. This study confirms the signal from preclinical cardiac repolarization models (human ether-a-go-go-related gene, guinea pig monophas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa6cdbb627717e61544155d5a6ff1f80
https://pubmed.ncbi.nlm.nih.gov/24917547

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