Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Alexander Brik"'
Autor:
Nataniel Białas, Nina Rosenkranz, Daniel Gilbert Weber, Kathrin Kostka, Georg Johnen, Aileen Winter, Alexander Brik, Kateryna Loza, Katja Szafranski, Thomas Brüning, Jürgen Bünger, Götz Westphal, Matthias Epple
Publikováno v:
Particle and Fibre Toxicology, Vol 21, Iss 1, Pp 1-20 (2024)
Abstract Background Inhalation of biopersistent fibers like asbestos can cause strong chronic inflammatory effects, often resulting in fibrosis or even cancer. The interplay between fiber shape, fiber size and the resulting biological effects is stil
Externí odkaz:
https://doaj.org/article/aef22fbba73a4b5c92e65cbdb147fe78
Autor:
Alexander Brik, Katharina Wichert, Daniel G. Weber, Katja Szafranski, Peter Rozynek, Swetlana Meier, Yon-Dschun Ko, Reinhard Büttner, Klaus Gerwert, Thomas Behrens, Thomas Brüning, Georg Johnen
Publikováno v:
BMC Research Notes, Vol 16, Iss 1, Pp 1-7 (2023)
Abstract Objective Lung cancer is the second most frequent cancer type and the most common cause of cancer-related deaths worldwide. Alteration of gene copy numbers are associated with lung cancer and the determination of copy number variations (CNV)
Externí odkaz:
https://doaj.org/article/4d4b32ed6fb3484da5c41823e17232a2
Autor:
Daniel G. Weber, Swaantje Casjens, Alexander Brik, Irina Raiko, Martin Lehnert, Dirk Taeger, Jan Gleichenhagen, Jens Kollmeier, Torsten T. Bauer, Thomas Brüning, Georg Johnen, the MoMar study group
Publikováno v:
Biomarker Research, Vol 8, Iss 1, Pp 1-11 (2020)
Abstract Background For the detection of malignant mesothelioma additional markers are needed besides the established panel consisting of calretinin and mesothelin. The aim of this study was the identification and verification of long non-coding RNAs
Externí odkaz:
https://doaj.org/article/bea13f3215704da2ab4816e0d01936fe
Autor:
Carmina Jiménez-Ramírez, Daniel Gilbert Weber, Guadalupe Aguilar-Madrid, Alexander Brik, Cuauhtémoc Arturo Juárez-Pérez, Swaantje Casjens, Irina Raiko, Thomas Brüning, Georg Johnen, Alejandro Cabello-López
Publikováno v:
PLoS ONE, Vol 17, Iss 10 (2022)
Malignant pleural mesothelioma (MPM) is a cancer associated with asbestos exposure and its diagnosis is challenging due to the moderate sensitivities of the available methods. In this regard, miR-103a-3p was considered to increase the sensitivity of
Externí odkaz:
https://doaj.org/article/358955d952ab433faf7e8bfa2d0590bf
Autor:
Daniel Gilbert Weber, Alexander Brik, Swaantje Casjens, Katarzyna Burek, Martin Lehnert, Beate Pesch, Dirk Taeger, Thomas Brüning, Georg Johnen, the MoMar study group
Publikováno v:
BMC Research Notes, Vol 12, Iss 1, Pp 1-6 (2019)
Abstract Objective Malignant mesothelioma is an aggressive cancer of the serous membranes. For the detection of the tumor at early stages non- or minimally-invasive biomarkers are needed. The circulating biomarkers miR-132-3p, miR-126-3p, and miR-103
Externí odkaz:
https://doaj.org/article/3e2face1f8ee488bbcb4b20ede36ca14
Autor:
Dirk Theegarten, Thomas Brüning, Swetlana Meier, Daniel G. Weber, Georg Johnen, Alexander Brik, Thomas Behrens, Swaantje Casjens, Kaid Darwiche, P. Rozynek, Georgios Stamatis
Publikováno v:
Disease Markers, Vol 2020 (2020)
Background. MYC (v-myc avian myelocytomatosis viral oncogene homolog) is one of the most frequently amplified genes in lung tumors. For the analysis of gene copy number variations, dPCR (digital PCR) is an appropriate tool. The aim of our study was t
Autor:
Alexander Brik, Bryan Hellack, Georg Johnen, Götz A. Westphal, Christian Monsé, Daniel G. Weber, Nina Kaiser, Thomas Brüning, Isabell Föhring, Markus Mattenklott, Jürgen Bünger, Nina Rosenkranz
Publikováno v:
Toxicology in Vitro. 58:215-223
Biopersistent pro-inflammatory fibers are suspected human carcinogens. Cytotoxicity and transcription of pro- and anti-inflammatory mediators of different fibers were investigated in functional relationship to chemotaxis in vitro as a model for fiber
Autor:
Alexander, Brik, Daniel G, Weber, Swaantje, Casjens, Peter, Rozynek, Swetlana, Meier, Thomas, Behrens, Georgios, Stamatis, Kaid, Darwiche, Dirk, Theegarten, Thomas, Brüning, Georg, Johnen
Publikováno v:
Disease markers. 2020
The results of theThe results of the study show that dPCR is an accurate and reliable method for the determination of
Autor:
Karolina Edlund, Mikheil Gogiashvili, Jörg Rahnenführer, Kathrin Gianmoena, Rosemarie Marchan, Jan G. Hengstler, Alexander Brik, Jörg Lambert, Roland Hergenröder, Cristina Cadenas, Birte Hellwig, Jan T. Andersson, Katrin Madjar
Publikováno v:
Analytical and Bioanalytical Chemistry. 409:1591-1606
Metabolic perturbations resulting from excessive hepatic fat accumulation are poorly understood. Thus, in this study, leptin-deficient ob/ob mice, a mouse model of fatty liver disease, were used to investigate metabolic alterations in more detail. Me
Autor:
Mikheil, Gogiashvili, Karolina, Edlund, Kathrin, Gianmoena, Rosemarie, Marchan, Alexander, Brik, Jan T, Andersson, Jörg, Lambert, Katrin, Madjar, Birte, Hellwig, Jörg, Rahnenführer, Jan G, Hengstler, Roland, Hergenröder, Cristina, Cadenas
Publikováno v:
Analytical and bioanalytical chemistry. 409(6)
Metabolic perturbations resulting from excessive hepatic fat accumulation are poorly understood. Thus, in this study, leptin-deficient ob/ob mice, a mouse model of fatty liver disease, were used to investigate metabolic alterations in more detail. Me