Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Alexander Bragat"'
Autor:
Zhigang Yu, Andrew Shenker, Frank LaCreta, Stanford Jhee, Janice Pursley, Jessie Wang, Charles Frost, Alexander Bragat
Publikováno v:
Clinical Pharmacology : Advances and Applications
Charles Frost,1 Andrew Shenker,1 Stanford Jhee,2 Zhigang Yu,1 Jessie Wang,3 Alexander Bragat,1 Janice Pursley,4 Frank LaCreta1 1Exploratory Clinical and Translational Research, Bristol-Myers Squibb, Princeton, NJ, USA; 2PAREXEL International Early Ph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d901ffc0feca5087f7002b7bb56e87a7
https://www.dovepress.com/evaluation-of-the-single-dose-pharmacokinetics-and-pharmacodynamics-of-peer-reviewed-article-CPAA
https://www.dovepress.com/evaluation-of-the-single-dose-pharmacokinetics-and-pharmacodynamics-of-peer-reviewed-article-CPAA
Publikováno v:
Clinical Pharmacology in Drug Development. 2:120-132
Migalastat HCl is an investigational, oral treatment for Fabry disease, an X-linked lysosomal storage disorder. Four Phase 1 studies were conducted to determine the pharmacokinetics, pharmacodynamics, safety, and tolerability of migalastat. Healthy v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d1eed33a4fc1ed8500e557de94a6324d
https://doi.org/10.1002/cpdd.1
https://doi.org/10.1002/cpdd.1
Autor:
Jeff Castelli, Sheela Sitaraman, Dan Walker, J. Charles Jennette, Pol Boudes, Alexander Bragat, Laura Barisoni, Robert B. Colvin
Publikováno v:
Archives of Pathology & Laboratory Medicine. 136:816-824
Context.—Assessing the amount of globotriaosylceramide inclusions in renal peritubular capillaries by a semiquantitative approach is a standard and useful measure of therapeutic efficacy in Fabry disease, achievable by light microscopy analysis. Ob
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8682c340623993fc67981a84c5c6db08
https://doi.org/10.5858/arpa.2011-0350-oa
https://doi.org/10.5858/arpa.2011-0350-oa
Publikováno v:
Clinical pharmacology in drug development. 2(2)
Migalastat HCl is an investigational, oral treatment for Fabry disease, an X-linked lysosomal storage disorder. Four Phase 1 studies were conducted to determine the pharmacokinetics, pharmacodynamics, safety, and tolerability of migalastat. Healthy v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5978c37e13a4011c6249466b675f4fa4
https://pubmed.ncbi.nlm.nih.gov/27121667
https://pubmed.ncbi.nlm.nih.gov/27121667
Autor:
Samuel J. Mann, Phyllis August, Thomas G. Pickering, Rosemerie Marion, Mark S. Pecker, Jon D. Blumenfeld, Julio E. Sotelo, Jean E. Sealey, John H. Laragh, Alexander Bragat
Publikováno v:
American journal of hypertension. 12(5)
Although beta-adrenergic-blocking drugs suppress the renin system (RAAS), plasma angiotensin II (Ang II) responses during beta-blockade have not been defined. This study quantifies the effects of beta-blockade on the RAAS and examines its impact on p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73498eb98d9f4ce506d284f5985632b9
https://pubmed.ncbi.nlm.nih.gov/10342782
https://pubmed.ncbi.nlm.nih.gov/10342782
Autor:
Dominique P. Germain, Fatih Süheyl Ezgü, Sheela Sitaraman, Claudio Feliciani, Pol Boudes, Rosemary Schroyer, Suma P. Shankar, Alexander Bragat, Salim Janmohamed, Kathy Nicholls, Shiona M. Laing
Publikováno v:
Molecular Genetics and Metabolism. 108:S70
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::511ace2cbdb4ea6ec0609c00d8c0b093
https://doi.org/10.1016/j.ymgme.2012.11.182
https://doi.org/10.1016/j.ymgme.2012.11.182
Autor:
Sheela Sitaraman, Pol Boudes, J. C. Jennette, Jeffrey P. Castelli, D. Walker, Laura Barisoni, Alexander Bragat, Robert B. Colvin
Publikováno v:
Archives of Pathology & Laboratory Medicine. 136:842-842
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::49fe41326bc876ee57c7b6460af6769e
https://doi.org/10.5858/1543-2165-136.8.842
https://doi.org/10.5858/1543-2165-136.8.842
Autor:
David J. Lockhart, Derralynn Hughes, Jeff Castelli, Pol Boudes, Kathy Nicholls, Charles Jennette, Sheela Sitaraman, Roberto Giugliani, Laura Barisoni, Atul Mehta, Alexander Bragat, Dominique P. Germain
Publikováno v:
Orphanet Journal of Rare Diseases
Orphanet Journal of Rare Diseases, Vol 7, Iss 1, p 91 (2012)
Orphanet Journal of Rare Diseases, Vol 7, Iss 1, p 91 (2012)
Background Fabry disease (FD) is a genetic disorder resulting from deficiency of the lysosomal enzyme α-galactosidase A (α-Gal A), which leads to globotriaosylceramide (GL-3) accumulation in multiple tissues. We report on the safety and pharmacodyn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57788d1787b19a818bf8a76663e2462e
https://doi.org/10.1186/1750-1172-7-91
https://doi.org/10.1186/1750-1172-7-91
Autor:
Jeff Castelli, Alexander Bragat, Robert B. Colvin, Laura Barisoni, Pol Boudes, Charles Jennette, Sheela Sitaraman
Publikováno v:
Molecular Genetics and Metabolism. 102:S7
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4b62e32a698315d9f525fcff81629a53
https://doi.org/10.1016/j.ymgme.2010.11.022
https://doi.org/10.1016/j.ymgme.2010.11.022
Autor:
Randall Stoltz, Sheela Sitaraman, Jane Royalty, Richard Lazauskas, George R. Lankas, Ken Valenzano, Douglas Stuart Greene, Alexander Bragat, Pol Boudes, Mathews Adera
Publikováno v:
Molecular Genetics and Metabolism. 102:S4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2f266d79704c8d518abb03855913e06e
https://doi.org/10.1016/j.ymgme.2010.11.011
https://doi.org/10.1016/j.ymgme.2010.11.011