Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Alexander Borodavka"'
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 9, Iss 1, Pp 1-2 (2024)
Externí odkaz:
https://doaj.org/article/661b3caf2e32450db091399a7a18d021
Autor:
Tomas Sneideris, Nadia A. Erkamp, Hannes Ausserwöger, Kadi L. Saar, Timothy J. Welsh, Daoyuan Qian, Kai Katsuya-Gaviria, Margaret L. L. Y. Johncock, Georg Krainer, Alexander Borodavka, Tuomas P. J. Knowles
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Antimicrobial peptides (AMPs), which combat bacterial infections by disrupting the bacterial cell membrane or interacting with intracellular targets, are naturally produced by a number of different organisms, and are increasingly also explor
Externí odkaz:
https://doaj.org/article/f347a58e300d44799db612aff9c099ee
Autor:
Christine T Styles, Jie Zhou, Katie E Flight, Jonathan C Brown, Charlotte Lewis, Xinyu Wang, Michael Vanden Oever, Thomas P Peacock, Ziyin Wang, Rosie Millns, John S O’Neill, Alexander Borodavka, Joe Grove, Wendy S Barclay, John S Tregoning, Rachel S Edgar
Publikováno v:
EMBO Molecular Medicine, Vol 16, Iss 7, Pp 1751-1751 (2024)
Externí odkaz:
https://doaj.org/article/f4a74545bc594cc4bcccd449114fd4d7
Publikováno v:
Viruses, Vol 16, Iss 6, p 814 (2024)
Rotaviruses (RVs) are 11-segmented, double-stranded (ds) RNA viruses and important causes of acute gastroenteritis in humans and other animal species. Early RV particle assembly is a multi-step process that includes the assortment, packaging and repl
Externí odkaz:
https://doaj.org/article/c542fb81810449c2b787eba99922e6fe
Autor:
Christine T Styles, Jie Zhou, Katie E Flight, Jonathan C Brown, Charlotte Lewis, Xinyu Wang, Michael Vanden Oever, Thomas P Peacock, Ziyin Wang, Rosie Millns, John S O'Neill, Alexander Borodavka, Joe Grove, Wendy S Barclay, John S Tregoning, Rachel S Edgar
Publikováno v:
EMBO Molecular Medicine, Vol 15, Iss 12, Pp n/a-n/a (2023)
Abstract Viruses are vulnerable as they transmit between hosts, and we aimed to exploit this critical window. We found that the ubiquitous, safe, inexpensive and biodegradable small molecule propylene glycol (PG) has robust virucidal activity. Propyl
Externí odkaz:
https://doaj.org/article/81c9583b032d41f389c366a3cc12589e
Autor:
William E. Arter, Runzhang Qi, Nadia A. Erkamp, Georg Krainer, Kieran Didi, Timothy J. Welsh, Julia Acker, Jonathan Nixon-Abell, Seema Qamar, Jordina Guillén-Boixet, Titus M. Franzmann, David Kuster, Anthony A. Hyman, Alexander Borodavka, Peter St George-Hyslop, Simon Alberti, Tuomas P. J. Knowles
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-10 (2022)
A central concept for characterising phase-separating systems is the phase diagram but generation of such diagrams for biomolecular systems is typically slow and low-throughput. Here the authors describe PhaseScan, a combinatorial droplet microfluidi
Externí odkaz:
https://doaj.org/article/21a365c2a2af4ba08de716204af10bed
Autor:
Sebastian Strauss, Julia Acker, Guido Papa, Daniel Desirò, Florian Schueder, Alexander Borodavka, Ralf Jungmann
Publikováno v:
eLife, Vol 12 (2023)
Rotaviruses transcribe 11 distinct RNAs that must be co-packaged prior to their replication to make an infectious virion. During infection, nontranslating rotavirus transcripts accumulate in cytoplasmic protein-RNA granules known as viroplasms that s
Externí odkaz:
https://doaj.org/article/0691ba990b834e63b79cf7f1ae404889
Publikováno v:
Viruses, Vol 13, Iss 7, p 1349 (2021)
Viroplasms are cytoplasmic, membraneless structures assembled in rotavirus (RV)-infected cells, which are intricately involved in viral replication. Two virus-encoded, non-structural proteins, NSP2 and NSP5, are the main drivers of viroplasm formatio
Externí odkaz:
https://doaj.org/article/8c250d22e61846dc840dd71f200b725d
Publikováno v:
eLife, Vol 6 (2017)
Segmented RNA viruses are ubiquitous pathogens, which include influenza viruses and rotaviruses. A major challenge in understanding their assembly is the combinatorial problem of a non-random selection of a full genomic set of distinct RNAs. This pro
Externí odkaz:
https://doaj.org/article/67b7891992914ca8bbfe5bd850b16b6c
Autor:
Alexander Borodavka, Julia Acker
Publikováno v:
Annual Review of Virology. 10
Phase separation of viral biopolymers is a key factor in the formation of cytoplasmic viral inclusions, known as sites of virus replication and assembly. This review describes the mechanisms and factors that affect phase separation in viral replicati