Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Alexander Bondoc"'
Autor:
Ruhi Gulati, Michael Johnston, Maria Rivas, Ashley Cast, Meenasri Kumbaji, Margaret A. Hanlon, Sanghoon Lee, Ping Zhou, Charissa Lake, Emily Schepers, Kyung‐Won Min, Je‐Hyun Yoon, Rebekah Karns, Lola M. Reid, Dolores Lopez‐Terrada, Lubov Timchenko, Sreeja Parameswaran, Matthew T. Weirauch, Sarangarajan Ranganathan, Alexander Bondoc, James Geller, Gregory Tiao, Soona Shin, Nikolai Timchenko
Publikováno v:
Hepatology Communications, Vol 6, Iss 10, Pp 2950-2963 (2022)
Abstract Fibrolamellar hepatocellular carcinoma (FLC) is a disease that occurs in children and young adults. The development of FLC is associated with creation of a fusion oncoprotein DNAJB1‐PKAc kinase, which activates multiple cancer‐associated
Externí odkaz:
https://doaj.org/article/3b39dff74afb4b70b221609038dea359
Autor:
Katherine M. Somers, Rachel Bernstein Tabbouche, Alexander Bondoc, Alexander J. Towbin, Sarangarajan Ranganathan, Greg Tiao, James I. Geller
Publikováno v:
Cancers, Vol 15, Iss 15, p 3921 (2023)
Background: Hepatoblastoma (HB) is the most common liver malignancy in children. There is no standard of care for management of relapsed/refractory HB (rrHB) and reports in the literature are limited. Objective: To describe presenting features, biolo
Externí odkaz:
https://doaj.org/article/0d36aff92520419b84b7066063032b18
Autor:
Senyo S. Whyte, Rebekah Karns, Kyung‐Won Min, Jung‐Hyun Cho, Sanghoon Lee, Charissa Lake, Alexander Bondoc, Je‐Hyun Yoon, Soona Shin
Publikováno v:
Cancer Reports, Vol 6, Iss 1, Pp n/a-n/a (2023)
Abstract Background Pediatric hepatocellular carcinoma (HCC) is a group of liver cancers whose mechanisms behind their pathogenesis and progression are poorly understood. Aim We aimed to identify alterations in the expression of miRNAs and their puta
Externí odkaz:
https://doaj.org/article/6bcf8f176bdb4ce09cc9364855d78339
Autor:
Alexander Bondoc, Kathryn Glaser, Kang Jin, Charissa Lake, Stefano Cairo, James Geller, Gregory Tiao, Bruce Aronow
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
Bondoc et al perform single-cell RNA-Seq profiling of Hepatoblastoma, background liver, and patient-derived xenografts to investigate cell-type heterogeneity and characterise the driver malignant cell cluster.
Externí odkaz:
https://doaj.org/article/1ae5ebea38d9407bb8359463ea860fc8
Autor:
Zishaan Farooqui, Michael Johnston, Emily Schepers, Nathalie Brewer, Stephen Hartman, Todd Jenkins, Alexander Bondoc, Ahna Pai, James Geller, Gregory M. Tiao
Publikováno v:
Children, Vol 10, Iss 5, p 890 (2023)
Hepatoblastoma is the most common malignant liver tumor of childhood, with liver transplant and extended resection used as surgical treatments for locally advanced tumors. Although each approach has well-described post-operative complications, qualit
Externí odkaz:
https://doaj.org/article/cf6d0689c80541fa9fe237c0cb389f5c
Autor:
Maria Rivas, Michael E. Johnston, II, Ruhi Gulati, Meenasri Kumbaji, Talita Ferreira Margues Aguiar, Lubov Timchenko, Ana Krepischi, Soona Shin, Alexander Bondoc, Gregory Tiao, James Geller, Nikolai Timchenko
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 5, Pp 1669-1682 (2021)
Background & Aims: Epigenetic regulation of gene expression plays a critical role in the development of liver cancer; however, the molecular mechanisms of epigenetic-driven liver cancers are not well understood. The aims of this study were to examine
Externí odkaz:
https://doaj.org/article/a79ef3c66404472896ca72ae3a9c2d38
Autor:
Astha Malik, Unmesha Thanekar, Surya Amarachintha, Reena Mourya, Shreya Nalluri, Alexander Bondoc, Pranavkumar Shivakumar
Publikováno v:
Frontiers in Oncology, Vol 10 (2021)
Hepatocellular carcinoma (HCC) is the most common primary malignancy of the liver and a leading cause of death in the US and worldwide. HCC remains a global health problem and is highly aggressive with unfavorable prognosis. Even with surgical interv
Externí odkaz:
https://doaj.org/article/b6afafcdbd614ed3a613938a56aef9f0
Publikováno v:
Cells, Vol 10, Iss 12, p 3461 (2021)
Biliary atresia (BA) is an obstructive neonatal cholangiopathy leading to liver cirrhosis and end stage liver disease. A Kasai portoenterostomy may restore biliary drainage, but most patients ultimately require liver transplantation for survival. At
Externí odkaz:
https://doaj.org/article/ec952950420847bb8396f17cb9eea2ef
Autor:
Sujit K Mohanty, Bryan Donnelly, Alexander Bondoc, Mubeen Jafri, Ashley Walther, Abigail Coots, Monica McNeal, David Witte, Gregory M Tiao
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e69069 (2013)
Biliary atresia (BA) is a neonatal disease that results in obliteration of the biliary tree. The murine model of BA, which mirrors the human disease, is based upon infection of newborn mice with rhesus rotavirus (RRV), leading to an obstructive chola
Externí odkaz:
https://doaj.org/article/88ad68ed56fa4af881c3b3f594ca9dbc
Autor:
Li Fan, Qingfei Pan, Wentao Yang, Selene C. Koo, Cheng Tian, Liyuan Li, Meifen Lu, Anthony Brown, Bensheng Ju, John Easton, Sarangarajan Ranganathan, Soona Shin, Alexander Bondoc, Jun J. Yang, Jiyang Yu, Liqin Zhu
Publikováno v:
Hepatology. 76:1275-1290
Hepatoblastoma (HB) is the most common pediatric liver cancer. Its predominant occurrence in very young children led us to investigate whether the neonatal liver provides a protumorigenic niche to HB development.HB development was compared between or