Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Alexander Boecker"'
Publikováno v:
Cell Reports, Vol 42, Iss 5, Pp 112448- (2023)
Summary: Gain-of-function mutations in the LRRK2 gene cause Parkinson’s disease (PD), increasing phosphorylation of RAB GTPases through hyperactive kinase activity. We find that LRRK2-hyperphosphorylated RABs disrupt the axonal transport of autopha
Externí odkaz:
https://doaj.org/article/0e1af3ea98cc466fb9c9dea8dce782a5
Autor:
Lisa M Strong, Chunmei Chang, Julia F Riley, C Alexander Boecker, Thomas G Flower, Cosmo Z Buffalo, Xuefeng Ren, Andrea KH Stavoe, Erika LF Holzbaur, James H Hurley
Publikováno v:
eLife, Vol 10 (2021)
Autophagy is a cellular process that degrades cytoplasmic cargo by engulfing it in a double-membrane vesicle, known as the autophagosome, and delivering it to the lysosome. The ATG12–5–16L1 complex is responsible for conjugating members of the ub
Externí odkaz:
https://doaj.org/article/3680dcace3464a88937af5f1d613cc8d
Autor:
Sunetra Sase, Akshata A Almad, C Alexander Boecker, Pedro Guedes-Dias, Jian J Li, Asako Takanohashi, Akshilkumar Patel, Tara McCaffrey, Heta Patel, Divya Sirdeshpande, Julian Curiel, Judy Shih-Hwa Liu, Quasar Padiath, Erika LF Holzbaur, Steven S Scherer, Adeline Vanderver
Publikováno v:
eLife, Vol 9 (2020)
Mutations in TUBB4A result in a spectrum of leukodystrophy including Hypomyelination with Atrophy of Basal Ganglia and Cerebellum (H-ABC), a rare hypomyelinating leukodystrophy, often associated with a recurring variant p.Asp249Asn (D249N). We have d
Externí odkaz:
https://doaj.org/article/d63c220dcb804fd689ffcb48f6975f30
Autor:
C. Alexander Boecker
This protocol describes the preparation and culture of mouse primary cortical neurons for live-imaging experiments. Cortices were dissected from mouse embryos at day 15.5. Cortical neurons were isolated by digestion with 0.25% Trypsin and trituration
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7d514dbd9044dfcc27bb295be46b9431
https://doi.org/10.17504/protocols.io.81wgby723vpk/v1
https://doi.org/10.17504/protocols.io.81wgby723vpk/v1
Publikováno v:
Autophagy
Parkinson disease (PD)-causing mutations in the LRRK2 (leucine rich repeat kinase 2) gene hyperactivate LRRK2 kinase activity. Here, we discuss our recent work linking LRRK2 hyperactivation to defective axonal autophagosome transport in neurons. In t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6da893c1cf606b9e9af8d4361990bb5
https://doi.org/10.1080/15548627.2021.1936933
https://doi.org/10.1080/15548627.2021.1936933
Autor:
James H. Hurley, Xuefeng Ren, Julia F Riley, Chunmei Chang, Erika L.F. Holzbaur, Lisa M Strong, C Alexander Boecker, Andrea K. H. Stavoe, Cosmo Z. Buffalo, Thomas G Flower
Publikováno v:
eLife, Vol 10 (2021)
eLife
eLife
Autophagy is a cellular process that degrades cytoplasmic cargo by engulfing it in a double-membrane vesicle, known as the autophagosome, and delivering it to the lysosome. The ATG12–5–16L1 complex is responsible for conjugating members of the ub
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7ee5bd934cb0b2a232e7813cd90c5fe
https://elifesciences.org/articles/70372
https://elifesciences.org/articles/70372
Autor:
Xuefeng Ren, Julia F Riley, C Alexander Boecker, Lisa M Strong, Thomas G Flower, Andrea K.H. Stavoe, Erika L.F. Holzbaur, James H. Hurley, Cosmo Z. Buffalo, Chunmei Chang
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dcf4f47e9a11d137228fdc20317db6a1
https://doi.org/10.7554/elife.70372.sa2
https://doi.org/10.7554/elife.70372.sa2
Autor:
Elizabeth R. Gallagher, Mara A. Olenick, Erika L.F. Holzbaur, Clemens Alexander Boecker, Michael E. Ward
Publikováno v:
Traffic
Induced pluripotent stem cells (iPSCs) hold promise to revolutionize studies of intracellular transport in live human neurons and to shed new light on the role of dysfunctional transport in neurodegenerative disorders. Here, we describe an approach f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5119c9a38a8657a366d6622a76635007
https://doi.org/10.1111/tra.12701
https://doi.org/10.1111/tra.12701
Publikováno v:
Curr Opin Neurobiol
Autophagy and endo-lysosomal degradation are two parallel degradation pathways essential for maintaining neuronal health and function. Autophagosomes and endosomes sequester cellular cargo through different mechanisms, but these pathways converge upo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4e58b28224fbf1574e335730464f1a0
https://doi.org/10.1016/j.conb.2019.01.005
https://doi.org/10.1016/j.conb.2019.01.005
Autor:
Chunmei Chang, C Alexander Boecker, Erika L.F. Holzbaur, James H. Hurley, Xuefeng Ren, Andrea K. H. Stavoe, Lisa M Strong, Cosmo Z. Buffalo, Thomas G Flower
Autophagy is a cellular process that degrades cytoplasmic cargo by engulfing it in a double membrane vesicle, known as the autophagosome, and delivering it to the lysosome. The ATG12–5-16L1 complex is responsible for conjugating members of the ubiq
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::60ca6845c44e3ad2ea4de14158f87c4a
https://doi.org/10.1101/2021.05.14.444175
https://doi.org/10.1101/2021.05.14.444175