Zobrazeno 1 - 10
of 55
pro vyhledávání: '"Alexander Bick"'
Publikováno v:
Genetics in Medicine Open, Vol 1, Iss 1, Pp 100822- (2023)
Purpose: As polygenic risk scores (PRSs) enter clinical practice, health care providers’ and the publics’ comprehension of PRS results are of great importance; yet, they are poorly understood. We present the Vanderbilt polygenic risk scores knowl
Externí odkaz:
https://doaj.org/article/fc808c84733843f585f46ecbc45def17
Publikováno v:
Journal of Clinical and Translational Science, Vol 7, Pp 91-91 (2023)
OBJECTIVES/GOALS: Clonal hematopoiesis of indeterminate potential (CHIP) is a common age-related condition that confers an increased risk of blood cancer, cardiovascular disease, and overall mortality. Larger proportions of blood cells with the CHIP
Externí odkaz:
https://doaj.org/article/b5f35813ccce4700b72e1d2e32ac710c
Autor:
James P. Pirruccello, Alexander Bick, Minxian Wang, Mark Chaffin, Samuel Friedman, Jie Yao, Xiuqing Guo, Bharath Ambale Venkatesh, Kent D. Taylor, Wendy S. Post, Stephen Rich, Joao A. C. Lima, Jerome I. Rotter, Anthony Philippakis, Steven A. Lubitz, Patrick T. Ellinor, Amit V. Khera, Sekar Kathiresan, Krishna G. Aragam
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
Structural changes to the left ventricle are characteristic of dilated cardiomyopathy (DCM), a disease for which many rare genetic variants are known. Here, Pirruccello et al. report GWAS of seven cardiac MRI measurements in the left ventricle and de
Externí odkaz:
https://doaj.org/article/bb4e68aedf3c4014874c9837a0e34e34
Autor:
Connor A Emdin, Mary E Haas, Amit V Khera, Krishna Aragam, Mark Chaffin, Derek Klarin, George Hindy, Lan Jiang, Wei-Qi Wei, Qiping Feng, Juha Karjalainen, Aki Havulinna, Tuomo Kiiskinen, Alexander Bick, Diego Ardissino, James G Wilson, Heribert Schunkert, Ruth McPherson, Hugh Watkins, Roberto Elosua, Matthew J Bown, Nilesh J Samani, Usman Baber, Jeanette Erdmann, Namrata Gupta, John Danesh, Danish Saleheen, Kyong-Mi Chang, Marijana Vujkovic, Ben Voight, Scott Damrauer, Julie Lynch, David Kaplan, Marina Serper, Philip Tsao, Million Veteran Program, Josep Mercader, Craig Hanis, Mark Daly, Joshua Denny, Stacey Gabriel, Sekar Kathiresan
Publikováno v:
PLoS Genetics, Vol 17, Iss 4, p e1009503 (2021)
[This corrects the article DOI: 10.1371/journal.pgen.1008629.].
Externí odkaz:
https://doaj.org/article/78e34e0716754e149bfe3845606b06c3
Autor:
Michael G. Levin, Jennifer Huffman, Anurag Verma, Alexis Rodriguez, Alexander Bick, Ravi Madduri, Scott Damrauer
Publikováno v:
JVS - Vascular Science, Vol 2, Iss , Pp 276- (2021)
Externí odkaz:
https://doaj.org/article/bec3c6ccb4c246d0901938437acf42ef
Autor:
Connor A Emdin, Mary E Haas, Amit V Khera, Krishna Aragam, Mark Chaffin, Derek Klarin, George Hindy, Lan Jiang, Wei-Qi Wei, Qiping Feng, Juha Karjalainen, Aki Havulinna, Tuomo Kiiskinen, Alexander Bick, Diego Ardissino, James G Wilson, Heribert Schunkert, Ruth McPherson, Hugh Watkins, Roberto Elosua, Matthew J Bown, Nilesh J Samani, Usman Baber, Jeanette Erdmann, Namrata Gupta, John Danesh, Danish Saleheen, Kyong-Mi Chang, Marijana Vujkovic, Ben Voight, Scott Damrauer, Julie Lynch, David Kaplan, Marina Serper, Philip Tsao, Million Veteran Program, Josep Mercader, Craig Hanis, Mark Daly, Joshua Denny, Stacey Gabriel, Sekar Kathiresan
Publikováno v:
PLoS Genetics, Vol 16, Iss 4, p e1008629 (2020)
Analyzing 12,361 all-cause cirrhosis cases and 790,095 controls from eight cohorts, we identify a common missense variant in the Mitochondrial Amidoxime Reducing Component 1 gene (MARC1 p.A165T) that associates with protection from all-cause cirrhosi
Externí odkaz:
https://doaj.org/article/39ed03da04ee4e80b0a235596832cedb
Autor:
Connor A. Emdin, Amit V. Khera, Mark Chaffin, Derek Klarin, Pradeep Natarajan, Krishna Aragam, Mary Haas, Alexander Bick, Seyedeh M. Zekavat, Akihiro Nomura, Diego Ardissino, James G. Wilson, Heribert Schunkert, Ruth McPherson, Hugh Watkins, Roberto Elosua, Matthew J. Bown, Nilesh J. Samani, Usman Baber, Jeanette Erdmann, Namrata Gupta, John Danesh, Daniel Chasman, Paul Ridker, Joshua Denny, Lisa Bastarache, Judith H. Lichtman, Gail D’Onofrio, Jennifer Mattera, John A. Spertus, Wayne H.-H. Sheu, Kent D. Taylor, Bruce M. Psaty, Stephen S. Rich, Wendy Post, Jerome I. Rotter, Yii-Der Ida Chen, Harlan Krumholz, Danish Saleheen, Stacey Gabriel, Sekar Kathiresan
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-8 (2018)
Examination of predicted loss-of-function (pLOF) genetic variants allows direct identification of genes with therapeutic potential. Here, Emdin et al. perform association analysis for 3759 pLOF variants with 24 traits and highlight protective variant
Externí odkaz:
https://doaj.org/article/5b782df960c64245a2f0b6bdfadd7745
Publikováno v:
The Quarterly Journal of Economics. 137:1901-1962
We document two robust features of the cross-sectional distribution of usual weekly hours and hourly wages. First, usual weekly hours are heavily concentrated around 40 hours, while at the same time a substantial share of total hours come from indivi
Publikováno v:
ATZelektronik. 16:46-51
Publikováno v:
ATZelectronics worldwide. 16:46-51