Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Alexander B. Seryshev"'
Autor:
Guizhen Fan, Mariah R. Baker, Lara E. Terry, Vikas Arige, Muyuan Chen, Alexander B. Seryshev, Matthew L. Baker, Steven J. Ludtke, David I. Yule, Irina I. Serysheva
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Here authors report cryo-EM structures of IP3R1 which provide atomic details of IP3, Ca2+ and ATP binding. Molecular motions of key domains and sidechains were found to regulate ligand binding and gating, which are validated by functional assays.
Externí odkaz:
https://doaj.org/article/19978619640c40e4bd70b573581c08b9
Autor:
Mariah R. Baker, Guizhen Fan, Alexander B. Seryshev, Melina A. Agosto, Matthew L. Baker, Irina I. Serysheva
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-11 (2021)
3D structure of full-length rat type 1 inositol 1,4,5-trisphosphate receptor reconstituted in lipid nanodisc is determined using single-particle cryo-electron microscopy. The study suggests conserved locations of protein-bound lipids among structural
Externí odkaz:
https://doaj.org/article/10329eb0880f42febb3dead68ecf9485
Autor:
Guizhen Fan, Mariah R. Baker, Lara E. Terry, Vikas Arige, Muyuan Chen, Alexander B. Seryshev, Matthew L. Baker, Steven J. Ludtke, David I. Yule, Irina I. Serysheva
Inositol-1,4,5-trisphosphate receptors (IP3Rs) are activated by IP3 and Ca2+ and their gating is regulated by various intracellular messengers that finely tune the channel activity. Here, using single particle cryo-EM analysis we determined 3D struct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ac020b81808b0a7919b5bffd9befaf0b
https://doi.org/10.1101/2022.05.27.493711
https://doi.org/10.1101/2022.05.27.493711
Autor:
Matthew L. Baker, Mariah R. Baker, Irina I. Serysheva, Melina A. Agosto, Alexander B. Seryshev, Guizhen Fan
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-11 (2021)
Type 1 inositol 1,4,5-trisphosphate receptor (IP3R1) is the predominant Ca2+-release channel in neurons. IP3R1 mediates Ca2+ release from the endoplasmic reticulum into the cytosol and thereby is involved in many physiological processes. Here, we pre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d70ee00c3490e9c108633be858ba6c9d
https://doi.org/10.1038/s42003-021-02156-4
https://doi.org/10.1038/s42003-021-02156-4
Autor:
Mariah R. Baker, Alexander B. Seryshev, Steven J. Ludtke, Irina I. Serysheva, Zhao Wang, Guizhen Fan, Matthew L. Baker
Publikováno v:
Cell Research
Inositol-1,4,5-trisphosphate receptors (InsP3Rs) are cation channels that mobilize Ca2+from intracellular stores in response to a wide range of cellular stimuli. The paradigm of InsP3R activation is the coupled interplay between binding of InsP3and C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de4a0ab70e46022bbf0c968b7611e59b
https://doi.org/10.1101/374041
https://doi.org/10.1101/374041