Zobrazeno 1 - 10
of 76
pro vyhledávání: '"Alexander B. Barnes"'
Autor:
Lea Marti, Nergiz Şahin Solmaz, Michal Kern, Anh Chu, Reza Farsi, Philipp Hengel, Jialiang Gao, Nicholas Alaniva, Michael A. Urban, Ronny Gunzenhauser, Alexander Däpp, Daniel Klose, Jens Anders, Giovanni Boero, Lukas Novotny, Martin Frimmer, Alexander B. Barnes
Publikováno v:
Journal of Magnetic Resonance Open, Vol 18, Iss , Pp 100145- (2024)
Higher magic angle spinning (MAS) frequencies than currently available are desirable to improve spectral resolution in NMR and EPR systems. While conventional strategies employ pneumatic spinning limited by fluid dynamics, this paper demonstrates the
Externí odkaz:
https://doaj.org/article/7cf05b623fc44141ba3c5087300c845b
Autor:
Selen Manioglu, Seyed Majed Modaresi, Johannes Thoma, Sarah A. Overall, Gregory Upert, Anatol Luther, Alexander B. Barnes, Daniel Obrecht, Daniel J. Müller, Sebastian Hiller
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-4 (2023)
Externí odkaz:
https://doaj.org/article/28d1b793f563437193c5331af1142178
Autor:
Selen Manioglu, Seyed Majed Modaresi, Noah Ritzmann, Johannes Thoma, Sarah A. Overall, Alexander Harms, Gregory Upert, Anatol Luther, Alexander B. Barnes, Daniel Obrecht, Daniel J. Müller, Sebastian Hiller
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Abstract Polymyxins are last-resort antibiotics with potent activity against multi-drug resistant pathogens. They interact with lipopolysaccharide (LPS) in bacterial membranes, but mechanistic details at the molecular level remain unclear. Here, we c
Externí odkaz:
https://doaj.org/article/0539de9771d743a08fee0604262fc708
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 5, p 4598 (2023)
Protein kinase C delta (PKC-δ) is an important signaling molecule in human cells that has both proapoptotic as well as antiapoptotic functions. These conflicting activities can be modulated by two classes of ligands, phorbol esters and bryostatins.
Externí odkaz:
https://doaj.org/article/70f025b301e74930853f1734da0920a0
Publikováno v:
Journal of Magnetic Resonance Open, Vol 8, Iss , Pp 100019- (2021)
To date, the most common method for setting the magic angle in magic angle spinning (MAS) solid state NMR experiments has been to monitor the NMR signal from a quadrupolar nuclide (such as 79Br in KBr) under MAS, then swapping to a sample of interest
Externí odkaz:
https://doaj.org/article/a45a1a54da45419e9194aaf739f38d7d
Autor:
Pin-Hui Chen, Chukun Gao, Lauren E. Price, Michael A. Urban, Thomas M. Osborn Popp, Alexander B. Barnes
Publikováno v:
Journal of Magnetic Resonance Open, Vol 8, Iss , Pp 100015- (2021)
Spherical rotors are a new paradigm in magic angle spinning (MAS) solid-state nuclear magnetic resonance (NMR). The simple geometry makes smaller diameter spheres and their utilization within narrow-bore NMR probes feasible. Here we report a 68 kHz s
Externí odkaz:
https://doaj.org/article/da88ed6fd0da4253acda9d7bc2d9af3d
Autor:
Sarah A. Overall, Alexander B. Barnes
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2021)
In-cell DNP is a growing application of NMR to the study of biomolecular structure and function within intact cells. An important unresolved question for in-cell DNP spectroscopy is the integrity of cellular samples under the cryogenic conditions of
Externí odkaz:
https://doaj.org/article/974fa7e930ec4b6caca32fc17e12d701
Autor:
Thomas M. Osborn Popp, Nicholas H. Alaniva, Ronny Gunzenhauser, Pin-Hui Chen, Chukun Gao, Lauren E. Price, Alexander B. Barnes
Publikováno v:
Journal of Magnetic Resonance Open, Vol 6, Iss , Pp 100014- (2021)
Precise alignment of the sample's spinning axis is vital for many magic angle spinning solid state NMR experiments. Spherical rotors are a new paradigm for magic angle spinning NMR, having been demonstrated to spin stably with little risk of rotor cr
Externí odkaz:
https://doaj.org/article/3c09931a51d941ec9533c0e5b1f5a735
Autor:
Hao Yang, Daryl Staveness, Steven M. Ryckbosch, Alison D. Axtman, Brian A. Loy, Alexander B. Barnes, Vijay S. Pande, Jacob Schaefer, Paul A. Wender, Lynette Cegelski
Publikováno v:
ACS Central Science, Vol 4, Iss 1, Pp 89-96 (2018)
Bryostatin 1 (henceforth bryostatin) is in clinical trials for the treatment of Alzheimer’s disease and for HIV/AIDS eradication. It is also a preclinical lead for cancer immunotherapy and other therapeutic indications. Yet nothing is known about t
Externí odkaz:
https://doaj.org/article/0c4021d3b7b3445188b8df92455c1628
Autor:
Brice J. Albert, Austin Niu, Rashmi Ramani, Garland R. Marshall, Paul A. Wender, Robert M. Williams, Lee Ratner, Alexander B. Barnes, George B. Kyei
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Abstract Current antiretroviral therapy (ART) for HIV/AIDS slows disease progression by reducing viral loads and increasing CD4 counts. Yet ART is not curative due to the persistence of CD4+ T-cell proviral reservoirs that chronically resupply active
Externí odkaz:
https://doaj.org/article/51c1c2571b74471db5299a641c3986a0