Zobrazeno 1 - 10
of 116
pro vyhledávání: '"Alexander B Taylor"'
Autor:
Sevan N Alwan, Alexander B Taylor, Jayce Rhodes, Michael Tidwell, Stanton F McHardy, Philip T LoVerde
Publikováno v:
PLoS Pathogens, Vol 19, Iss 7, p e1011018 (2023)
Human schistosomiasis is a neglected tropical disease caused by Schistosoma mansoni, S. haematobium, and S. japonicum. Praziquantel (PZQ) is the method of choice for treatment. Due to constant selection pressure, there is an urgent need for new thera
Externí odkaz:
https://doaj.org/article/145091b1d84e47368851c4e2839695f6
Autor:
Meghan A Guzman, Anastasia R Rugel, Reid S Tarpley, Sevan N Alwan, Frédéric D Chevalier, Dmytro P Kovalskyy, Xiaohang Cao, Stephen P Holloway, Timothy J C Anderson, Alexander B Taylor, Stanton F McHardy, Philip T LoVerde
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 14, Iss 8, p e0008517 (2020)
Currently there is only one method of treatment for human schistosomiasis, the drug praziquantel. Strong selective pressure has caused a serious concern for a rise in resistance to praziquantel leading to the necessity for additional pharmaceuticals,
Externí odkaz:
https://doaj.org/article/63cb9a6c7eed407f9070e62dc9bc98ef
Autor:
Frédéric D Chevalier, Winka Le Clec'h, Marina McDew-White, Vinay Menon, Meghan A Guzman, Stephen P Holloway, Xiaohang Cao, Alexander B Taylor, Safari Kinung'hi, Anouk N Gouvras, Bonnie L Webster, Joanne P Webster, Aidan M Emery, David Rollinson, Amadou Garba Djirmay, Khalid M Al Mashikhi, Salem Al Yafae, Mohamed A Idris, Hélène Moné, Gabriel Mouahid, P John Hart, Philip T LoVerde, Timothy J C Anderson
Publikováno v:
PLoS Pathogens, Vol 15, Iss 10, p e1007881 (2019)
Do mutations required for adaptation occur de novo, or are they segregating within populations as standing genetic variation? This question is key to understanding adaptive change in nature, and has important practical consequences for the evolution
Externí odkaz:
https://doaj.org/article/a50784decc0348ce8bf4dc913999942b
Autor:
Anthony P King, Maria Muzik, Lindsay Hamilton, Alexander B Taylor, Katherine L Rosenblum, Israel Liberzon
Publikováno v:
PLoS ONE, Vol 11, Iss 8, p e0160473 (2016)
The DRD4 VNTR has been associated with child behavior problems in interaction with maternal insensitivity in European and American cohorts of preschoolers, with the 7-repeat (7R) allele associated with greater problems. We sought to replicate and exp
Externí odkaz:
https://doaj.org/article/30038642613b4f2ca8d37f01402a6ad9
Autor:
Alexander B Taylor, Livia Pica-Mattoccia, Chiara M Polcaro, Enrica Donati, Xiaohang Cao, Annalisa Basso, Alessandra Guidi, Anastasia R Rugel, Stephen P Holloway, Timothy J C Anderson, P John Hart, Donato Cioli, Philip T LoVerde
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 9, Iss 10, p e0004132 (2015)
For over two decades, a racemic mixture of oxamniquine (OXA) was administered to patients infected by Schistosoma mansoni, but whether one or both enantiomers exert antischistosomal activity was unknown. Recently, a ~30 kDa S. mansoni sulfotransferas
Externí odkaz:
https://doaj.org/article/3b7c1e7a5a064fd091f62e935ccc0828
Autor:
Philip T. LoVerde, Sevan N. Alwan, Alexander B. Taylor, Jayce Rhodes, Frédéric D. Chevalier, Timothy Jc Anderson, Stanton F. McHardy
Publikováno v:
International Journal for Parasitology: Drugs and Drug Resistance, Vol 18, Iss , Pp 103- (2022)
Externí odkaz:
https://doaj.org/article/db504295d1b64fbdba4f77b5d55ff3c7
Autor:
Meghan A. Guzman, Anastasia Rugel, Sevan N. Alwan, Reid Tarpley, Alexander B. Taylor, Frédéric D. Chevalier, George R. Wendt, James J. Collins, Timothy J. C. Anderson, Stanton F. McHardy, Philip T. LoVerde
Publikováno v:
Pharmaceutics, Vol 14, Iss 7, p 1416 (2022)
Oxamniquine (OXA) is a prodrug activated by a sulfotransferase (SULT) that was only active against Schistosoma mansoni. We have reengineered OXA to be effective against S. haematobium and S. japonicum. Three derivatives stand out, CIDD-0066790, CIDD-
Externí odkaz:
https://doaj.org/article/e5605799150f4a7ab88576d43918dca9
Autor:
Sevan N. Alwan, Alexander B. Taylor, Jayce Rhodes, Michael Tidwell, Stanton F. McHardy, Philip T. LoVerde
Human schistosomiasis is a neglected tropical disease caused bySchistosoma mansoni, S. haematobium,andS. japonicum.Praziquantel (PZQ) is the method of choice for treatment. Due to constant selection pressure, there is an urgent need for new therapies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0156157919f51d848e4d03e12b5d3ec0
https://doi.org/10.1101/2023.05.23.541778
https://doi.org/10.1101/2023.05.23.541778
Autor:
Alfred Amambua-Ngwa, Katrina A. Button-Simons, Xue Li, Sudhir Kumar, Katelyn Vendrely Brenneman, Marco Ferrari, Lisa A. Checkley, Meseret T. Haile, Douglas A. Shoue, Marina McDew-White, Sarah M. Tindall, Ann Reyes, Elizabeth Delgado, Haley Dalhoff, James K. Larbalestier, Roberto Amato, Richard D. Pearson, Alexander B. Taylor, François H. Nosten, Umberto D’Alessandro, Dominic Kwiatkowski, Ian H. Cheeseman, Stefan H. I. Kappe, Simon V. Avery, David J. Conway, Ashley M. Vaughan, Michael T. Ferdig, Timothy J. C. Anderson
Publikováno v:
Nature Microbiology.
Malaria parasites break down host haemoglobin into peptides and amino acids in the digestive vacuole for export to the parasite cytoplasm for growth: interrupting this process is central to the mode of action of several antimalarial drugs. Mutations
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6a35b58c849bdeda40f0a91f6a59661b
https://doi.org/10.1038/s41564-023-01377-z
https://doi.org/10.1038/s41564-023-01377-z
Autor:
Nathaniel E. Clark, Adam Katolik, Anastasia Welch, Christoph Schorl, Stephen P. Holloway, Jonathan P. Schuermann, P. John Hart, Alexander B. Taylor, Masad J. Damha, William G. Fairbrother
Publikováno v:
Biochemistry
The RNA lariat debranching enzyme is the sole enzyme responsible for hydrolyzing the 2′–5′ phosphodiester bond in RNA lariats produced by the spliceosome. Here we test the ability of Dbr1 to hydrolyze branched RNAs (bRNAs) which contain a 2′
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f67fef474ead4eaa9bf0c6612c34fee
https://europepmc.org/articles/PMC10308451/
https://europepmc.org/articles/PMC10308451/