Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Alexander B H, Bakker"'
Autor:
Cecile Geuijen, Paul Tacken, Liang-Chuan Wang, Rinse Klooster, Pieter Fokko van Loo, Jing Zhou, Arpita Mondal, Yao-bin Liu, Arjen Kramer, Thomas Condamine, Alla Volgina, Linda J. A. Hendriks, Hans van der Maaden, Eric Rovers, Steef Engels, Floris Fransen, Renate den Blanken-Smit, Vanessa Zondag-van der Zande, Abdul Basmeleh, Willem Bartelink, Ashwini Kulkarni, Wilfred Marissen, Cheng-Yen Huang, Leslie Hall, Shane Harvey, Soyeon Kim, Marina Martinez, Shaun O’Brien, Edmund Moon, Steven Albelda, Chrysi Kanellopoulou, Shaun Stewart, Horacio Nastri, Alexander B. H. Bakker, Peggy Scherle, Ton Logtenberg, Gregory Hollis, John de Kruif, Reid Huber, Patrick A. Mayes, Mark Throsby
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
The anti-tumour effect of immune checkpoint inhibitors is potentiated by CD137 agonists in preclinical models, but translation of these results to the clinical practice is hampered by toxicity. Authors describe here a human CD137xPD-L1 bispecific ant
Externí odkaz:
https://doaj.org/article/4044cbbb9c1d4937ac08f857eba69b30
Autor:
Camilla, De Nardis, Linda J A, Hendriks, Emilie, Poirier, Tudor, Arvinte, Piet, Gros, Alexander B H, Bakker, John, de Kruif
Publikováno v:
The Journal of biological chemistry. 292(35)
Bispecific antibodies show great promise as intrinsic combination therapies, but often suffer from poor physiochemical properties, many times related to poor heterodimerization. De Nardis et al. identify specific electrostatic interactions that facil
Autor:
Marjo Kestilä, Joseph H. Phillips, Tuomo Timonen, Leena Peltonen, Antti Salminen, Alexander B. H. Bakker, Juha Paloneva, Lewis L. Lanier, Jun Wu, Tom Böhling, P. Pekkarinen, Vesa Ruotsalainen, Panu Hakola
Publikováno v:
University of Helsinki
Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL; MIM 221770), also known as Nasu-Hakola disease, is a recessively inherited disease characterized by a combination of psychotic symptoms rapidly progressing to presen
Publikováno v:
The Journal of Immunology. 161:7-10
Several members of the Ly-49 receptor family inhibit NK cell-mediated lysis of targets expressing appropriate MHC class I molecules. Ly-49D and Ly-49H, two Ly-49 molecules that lack immunoreceptor tyrosine-based inhibitory motifs (ITIM) in their cyto
Publikováno v:
The Journal of Immunology. 160:5239-5245
NK cells and T cells express killer cell inhibitory receptors (KIR) recognizing polymorphic MHC class I molecules. Although prior studies have established that MHC class I can protect normal and transformed hematopoietic cells from NK cell lysis, the
Autor:
Alexander B. H. Bakker, Thomas Spies, Jun Wu, Lewis L. Lanier, Stefan Bauer, Yaoli Song, Joseph H. Phillips
Publikováno v:
Science, 285, 5428, pp. 730-732
Science, 285, 730-732
Science, 285, 730-732
Many immune receptors are composed of separate ligand-binding and signal-transducing subunits. In natural killer (NK) and T cells, DAP10 was identified as a cell surface adaptor protein in an activating receptor complex with NKG2D, a receptor for the
Autor:
Alexander B H, Bakker, Sonja, van den Oudenrijn, Arjen Q, Bakker, Nicole, Feller, Marja, van Meijer, Judith A, Bia, Mandy A C, Jongeneelen, Therese J, Visser, Nora, Bijl, Cecilia A W, Geuijen, Wilfred E, Marissen, Katarina, Radosevic, Mark, Throsby, Gerrit Jan, Schuurhuis, Gert J, Ossenkoppele, John, de Kruif, Jaap, Goudsmit, Ada M, Kruisbeek
Publikováno v:
Cancer research. 64(22)
Acute myeloid leukemia (AML) has a poor prognosis due to treatment-resistant relapses. A humanized anti-CD33 antibody (Mylotarg) showed a limited response rate in relapsed AML. To discover novel AML antibody targets, we selected a panel of single cha
Publikováno v:
Immunology today. 21(12)
DAP12, an ITAM-bearing transmembrane adaptor protein, associates non-covalently with receptors in natural killer (NK) and myeloid cells, and provides signaling function via the Syk and ZAP-70 tyrosine kinase activation pathways. Humans and mice lacki
Retinoic acid early inducible genes define a ligand family for the activating NKG2D receptor in mice
Autor:
Terri McClanahan, Adelheid Cerwenka, Jun Wu, Joseph H. Phillips, Alexander B. H. Bakker, Lewis L. Lanier, Janet Wagner
Publikováno v:
Immunity. 12(6)
Here we describe a family of GPI-anchored cell surface proteins that function as ligands for the mouse activating NKG2D receptor. These molecules are encoded by the retinoic acid early inducible (RAE-1) and H60 minor histocompatibility antigen genes
Publikováno v:
Human Immunology, 61, 18-27
Human Immunology, 61, 1, pp. 18-27
Human Immunology, 61, 1, pp. 18-27
A delicate balance between positive and negative signals regulates NK cell effector function. Activation of NK cells may be initiated by the triggering of multiple adhesion or costimulatory molecules, and can be counterbalanced by inhibitory signals