Zobrazeno 1 - 10
of 281
pro vyhledávání: '"Alexander Arlt"'
Autor:
Claudia Geismann, Charlotte Hauser, Frauke Grohmann, Christian Schneeweis, Nico Bölter, Jan-Paul Gundlach, Günter Schneider, Christoph Röcken, Christian Meinhardt, Heiner Schäfer, Stefan Schreiber, Alexander Arlt
Publikováno v:
Cell Death and Disease, Vol 14, Iss 1, Pp 1-10 (2023)
Abstract The emergence of resistance to systemic therapies in pancreatic ductal adenocarcinoma (PDAC) is still a major obstacle in clinical practice. Both, constitutive and inducible NF-κB activity are known as key players in this context. To identi
Externí odkaz:
https://doaj.org/article/c49d5f0c0be94c26918207d7b67b5744
Publikováno v:
Clinical Endoscopy, Vol 55, Iss 1, Pp 58-66 (2022)
Background/Aims Anastomotic leakage after esophageal surgery remains a feared complication. During the last decade, management of this complication changed from surgical revision to a more conservative and endoscopic approach. However, the treatment
Externí odkaz:
https://doaj.org/article/46dd5051886a489f8ec1aecb88d5082a
Autor:
Gaetan Aime Noubissi Nzeteu, Claudia Geismann, Alexander Arlt, Frederik J. H. Hoogwater, Maarten W. Nijkamp, N. Helge Meyer, Maximilian Bockhorn
Publikováno v:
Cancers, Vol 14, Iss 22, p 5483 (2022)
Tumor-related death is primarily caused by metastasis; consequently, understanding, preventing, and treating metastasis is essential to improving clinical outcomes. Metastasis is mainly governed by the dissemination of tumor cells in the systemic cir
Externí odkaz:
https://doaj.org/article/5db810973c3945469739ddb4b19bccfe
Autor:
Wiebke Breternitz, Friedrich Sandkühler, Frauke Grohmann, Jochen Hampe, Mario Brosch, Alexander Herrmann, Clemens Schafmayer, Christian Meinhardt, Stefan Schreiber, Alexander Arlt, Claudia Geismann
Publikováno v:
Cells, Vol 11, Iss 21, p 3504 (2022)
Obesity and obesity-associated diseases represent one of the key health challenges of our time. In this context, aberrant hepatic lipid accumulation is a central pathological aspect of non-alcoholic fatty liver disease (NAFLD). By comparing methylati
Externí odkaz:
https://doaj.org/article/933daf0b06b54792a193896036ad38eb
Autor:
Claudia Geismann, Alexander Arlt
Publikováno v:
Translational Oncology, Vol 14, Iss 1, Pp 100968- (2021)
Externí odkaz:
https://doaj.org/article/8b6b282d2dac4e6486bd643091594504
Autor:
Florian Tran, Christine Klein, Alexander Arlt, Simon Imm, Evelyn Knappe, Alison Simmons, Philip Rosenstiel, Philip Seibler
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Individualised cellular models of disease are a key tool for precision medicine to recapitulate chronic inflammatory processes. Organoid models can be derived from induced pluripotent stem cells (iPSCs) or from primary stem cells ex vivo. These model
Externí odkaz:
https://doaj.org/article/a98f95e7d3c54acfaf498dbdf52ed0ed
Autor:
Friederike Flachsbart, Janina Dose, Liljana Gentschew, Claudia Geismann, Amke Caliebe, Carolin Knecht, Marianne Nygaard, Nandini Badarinarayan, Abdou ElSharawy, Sandra May, Anne Luzius, Guillermo G. Torres, Marlene Jentzsch, Michael Forster, Robert Häsler, Kathrin Pallauf, Wolfgang Lieb, Céline Derbois, Pilar Galan, Dmitriy Drichel, Alexander Arlt, Andreas Till, Ben Krause-Kyora, Gerald Rimbach, Hélène Blanché, Jean-François Deleuze, Lene Christiansen, Kaare Christensen, Michael Nothnagel, Philip Rosenstiel, Stefan Schreiber, Andre Franke, Susanne Sebens, Almut Nebel
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
FOXO3 is one of the few established longevity genes. Here, the authors fine-map the FOXO3-longevity association to two intronic SNPs and, using luciferase assays and EMSAs, show that these SNPs affect binding of transcription factors CTCF and SRF and
Externí odkaz:
https://doaj.org/article/f1d90b23cde74314abd23e1b467785a0
Autor:
Claudia Geismann, Alexander Arlt
Publikováno v:
Cells, Vol 9, Iss 11, p 2353 (2020)
With a five-year survival rate under 9%, pancreatic ductal adenocarcinoma (PDAC) represents one of the deadliest tumors. Although the treatment options are slightly improving, PDAC is the second leading cause of cancer related death in 2020 in the US
Externí odkaz:
https://doaj.org/article/a9be00762cdf43f69fe3120c47775756
Autor:
Leontine Sandforth, Nourhane Ammar, Lisa Antonia Dinges, Christoph Röcken, Alexander Arlt, Susanne Sebens, Heiner Schäfer
Publikováno v:
Cancers, Vol 12, Iss 3, p 581 (2020)
Metabolite exchange between stromal and tumor cells or among tumor cells themselves accompanies metabolic reprogramming in cancer including pancreatic adenocarcinoma (PDAC). Some tumor cells import and utilize lactate for oxidative energy production
Externí odkaz:
https://doaj.org/article/a04e7ccd9c324a99b8f06a0b5722b775
Autor:
Claudia Geismann, Heiner Schäfer, Jan-Paul Gundlach, Charlotte Hauser, Jan-Hendrik Egberts, Günter Schneider, Alexander Arlt
Publikováno v:
Cancers, Vol 11, Iss 10, p 1445 (2019)
Pancreatic cancer is one of the carcinomas with the worst prognoses, as shown by its five-year survival rate of 9%. Although there have been new therapeutic innovations, the effectiveness of these therapies is still limited, resulting in pancreatic d
Externí odkaz:
https://doaj.org/article/a7bfc68b813c4950a70571284026df6a