Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Alexander Agrotis"'
Publikováno v:
Autophagy Reports, Vol 3, Iss 1 (2024)
Protein ATG8ylation refers to a post-translational modification involving covalent attachment of ubiquitin-like autophagy-related protein ATG8 (LC3/GABARAP) to other cellular proteins, with reversal mediated by ATG4 proteases. While lipid ATG8ylation
Externí odkaz:
https://doaj.org/article/28b3c83a71204668890066419ac4007b
Autor:
Niccolo Pengo, Krisna Prak, Joana R. Costa, Christin Luft, Alexander Agrotis, Jamie Freeman, Christina A. Gewinner, A. W. Edith Chan, David L. Selwood, Janos Kriston-Vizi, Robin Ketteler
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 6 (2018)
Autophagy protease ATG4B is a key regulator of the LC3/GABARAP conjugation system required for autophagosome formation, maturation and closure. Members of the ATG4 and the LC3/GABARAP family have been implicated in various diseases including cancer,
Externí odkaz:
https://doaj.org/article/604f0cb92baf46c28da8fdf84dc91d3d
Autor:
Alexander Agrotis, Robin Ketteler
Publikováno v:
Cells, Vol 9, Iss 1, p 53 (2019)
Autophagy is an evolutionary conserved stress survival pathway that has been shown to play an important role in the initiation, progression, and metastasis of multiple cancers; however, little progress has been made to date in translation of basic re
Externí odkaz:
https://doaj.org/article/fc58f1ed17ce45f2be303ff5801e20ef
Autor:
Alexander Agrotis, Frederic Lamoliatte, Thomas D Williams, Ailsa Black, Rhuari Horberry, Adrien Rousseau
Publikováno v:
Life Science Alliance. 6:e202201642
The homohexameric p97 complex, composed of Cdc48 subunits in yeast, is a crucial component of protein quality control pathways including ER-associated degradation. The complex acts to segregate protein complexes in an ATP-dependent manner, requiring
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d4507e48c9d581f7492e9d72dd8f1c08
https://doi.org/10.26508/lsa.202201642
https://doi.org/10.26508/lsa.202201642
Autor:
Pedro R. Cutillas, Alexander Agrotis, Stéphanie Kermorgant, Arran Dokal, Thomas D. Nightingale, Fanourios Michailidis, Jemima J. Burden, Marie Nollet, Robin Ketteler, Vinothini Rajeeve
LC3 (Light Chain 3) is a key player of autophagy, a major stress-responsive proteolysis pathway promoting cellular homeostasis. It coordinates the formation and maturation of autophagosomes and recruits cargo to be further degraded upon autophagosome
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9c3bfea8118a572e98f99f48e27821b1
https://doi.org/10.1101/2021.10.08.463639
https://doi.org/10.1101/2021.10.08.463639
Autor:
Thomas Williams, Roberta Cacioppo, Alexander Agrotis, Ailsa Black, Houjiang Zhou, Adrien Rousseau
Publikováno v:
Nature cell biology. 24(7)
When cells are stressed, bulk translation is often downregulated to reduce energy demands while stress-response proteins are simultaneously upregulated. To promote proteasome assembly and activity and maintain cell viability upon TORC1 inhibition, 19
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58abe579b64b219a7ef7c27e6e11a2e8
https://pubmed.ncbi.nlm.nih.gov/35739319
https://pubmed.ncbi.nlm.nih.gov/35739319
Autor:
Hannah M. Mitchison, Evie Robson, Dale Moulding, Andrew Rutman, Sam M. Janes, Daniel Peckham, Claire Smith, Dani Do Hyang Lee, Satyanarayana Somavarapu, Stephen L. Hart, Colin R. Butler, Philip L. Beales, Ersilia Nigro, Robert E. Hynds, Daniela Cardinale, Elisabeth Forsythe, Mahmoud R. Fassad, Robin Ketteler, Alexander Agrotis, Christopher O'Callaghan, Robert A. Hirst
Publikováno v:
The European Respiratory Journal
article-version (VoR) Version of Record
article-version (VoR) Version of Record
Background Development of therapeutic approaches for rare respiratory diseases is hampered by the lack of systems that allow medium-to-high-throughput screening of fully differentiated respiratory epithelium from affected patients. This is a particul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe7bdc80b9353d49a8bcebcfe1959983
http://hdl.handle.net/11591/467848
http://hdl.handle.net/11591/467848
Autor:
Mahmoud R. Fassad, Colin R. Butler, Satyanarayana Somavarapu, Sam M. Janes, Stephen L. Hart, Daniela Cardinale, Philip L. Beales, Dani Do Hyang Lee, Elisabeth Forsythe, Ersilia Nigro, Daniel Peckham, Hannah M. Mitchison, Andrew Rutman, Alexander Agrotis, Claire Smith, Christopher O'Callaghan, Robert E. Hynds, Robin Ketteler, Evie Robson, Dale Moulding, Robert A. Hirst
Development of therapeutic approaches for rare respiratory diseases is hampered by the lack of systems that allow medium-to-high-throughput screening of fully differentiated respiratory epithelium from affected patients. This is a particular problem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e48e63d1e5b9666a19b90d00ef0d315c
Autor:
Ingo Ahrens, Helena Domeij, Denijal Topcic, Izhak Haviv, Ruusu-Maaria Merivirta, Alexander Agrotis, Ephraem Leitner, Jeremy B Jowett, Christoph Bode, Martha Lappas, Karlheinz Peter
Publikováno v:
PLoS ONE, Vol 6, Iss 8, p e23210 (2011)
Endothelial progenitor cells (EPCs) can be purified from peripheral blood, bone marrow or cord blood and are typically defined by a limited number of cell surface markers and a few functional tests. A detailed in vitro characterization is often restr
Externí odkaz:
https://doaj.org/article/fd7ca2dbdcd84f2bab499a0fd8e977b7
Autor:
Alexander, Agrotis, Lucas, von Chamier, Harriet, Oliver, Koshiro, Kiso, Tanya, Singh, Robin, Ketteler
Publikováno v:
The Journal of Biological Chemistry
Microtubule-associated protein 1 light chain 3 α (LC3)/GABA type A receptor-associated protein (GABARAP) comprises a family of ubiquitin-like proteins involved in (macro)autophagy, an important intracellular degradation pathway that delivers cytopla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6832c054746226f674cff57f593d98fb
https://pubmed.ncbi.nlm.nih.gov/31315929
https://pubmed.ncbi.nlm.nih.gov/31315929