Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Alexander A. Soukas"'
Autor:
Ben Zhou, Yuyao Zhang, Sainan Li, Lianfeng Wu, Geza Fejes-Toth, Aniko Naray-Fejes-Toth, Alexander A. Soukas
Publikováno v:
Cell Reports, Vol 37, Iss 1, Pp 109785- (2021)
Summary: A hallmark of type 2 diabetes (T2D) is hepatic resistance to insulin’s glucose-lowering effects. The serum- and glucocorticoid-regulated family of protein kinases (SGK) is activated downstream of mechanistic target of rapamycin complex 2 (
Externí odkaz:
https://doaj.org/article/bf3437e737224b42bf79f1cf6078987f
Autor:
Shuying Xu, Marianela Feliu, Allison K. Lord, Daniel P. Lukason, Paige E. Negoro, Nida S. Khan, Zeina Dagher, Michael B. Feldman, Jennifer L. Reedy, Samantha N. Steiger, Jenny M. Tam, Alexander A. Soukas, David B. Sykes, Michael K. Mansour
Publikováno v:
Virulence, Vol 9, Iss 1, Pp 1150-1162 (2018)
Candida spp. are the fourth leading cause of nosocomial blood stream infections in North America. Candida glabrata is the second most frequently isolated species, and rapid development of antifungal resistance has made treatment a challenge. In this
Externí odkaz:
https://doaj.org/article/aaf0263e893d4e9ab7b1c1e88e54c095
Autor:
Christopher M. Webster, Elizabeth C. Pino, Christopher E. Carr, Lianfeng Wu, Ben Zhou, Lucydalila Cedillo, Michael C. Kacergis, Sean P. Curran, Alexander A. Soukas
Publikováno v:
Cell Reports, Vol 20, Iss 3, Pp 627-640 (2017)
Organisms must execute metabolic defenses to survive nutrient deprivation. We performed a genome-wide RNAi screen in Caenorhabditis elegans to identify fat regulatory genes indispensable for starvation resistance. Here, we show that opposing proteost
Externí odkaz:
https://doaj.org/article/4b497a686e6442d89ac74faa349deb0e
Autor:
Lucydalila Cedillo, Fasih M Ahsan, Sainan Li, Nicole L Stuhr, Yifei Zhou, Yuyao Zhang, Adebanjo Adedoja, Luke M Murphy, Armen Yerevanian, Sinclair Emans, Khoi Dao, Zhaozhi Li, Nicholas D Peterson, Jeramie Watrous, Mohit Jain, Sudeshna Das, Read Pukkila-Worley, Sean P Curran, Alexander A Soukas
Publikováno v:
eLife, Vol 12 (2023)
Biguanides, including the world’s most prescribed drug for type 2 diabetes, metformin, not only lower blood sugar, but also promote longevity in preclinical models. Epidemiologic studies in humans parallel these findings, indicating favorable effec
Externí odkaz:
https://doaj.org/article/5f9402d37613409b85d1992e1eaa7bee
Autor:
Sinclair W. Emans, Armen Yerevanian, Fasih M. Ahsan, Yifei Zhou, Lucydalila Cedillo, Alexander A. Soukas
Both Hedgehog (Hh) signaling and target of rapamycin complex 2 (TORC2) are central, evolutionarily conserved pathways that regulate development and metabolism. InC. elegans, loss of essential TORC2 component RICTOR (rict-1) causes delayed development
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7aadda13848dce5c8ab82fa5dcf37fe5
https://doi.org/10.1101/2022.11.17.517002
https://doi.org/10.1101/2022.11.17.517002
Autor:
Armen Yerevanian, Luke M. Murphy, Sinclair Emans, Yifei Zhou, Fasih M. Ahsan, Daniel Baker, Sainan Li, Adebanjo Adedoja, Lucydalila Cedillo, Nicole L. Stuhr, Einstein Gnanatheepam, Khoi Dao, Mohit Jain, Sean P. Curran, Irene Georgakoudi, Alexander A. Soukas
Publikováno v:
Aging cell. 21(11)
Riboflavin is an essential cofactor in many enzymatic processes and in the production of flavin adenine dinucleotide (FAD). Here, we report that the partial depletion of riboflavin through knockdown of the C. elegans riboflavin transporter 1 (rft-1)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1726de56d3d874ef7fdaa5e548845968
https://pubmed.ncbi.nlm.nih.gov/36181246
https://pubmed.ncbi.nlm.nih.gov/36181246
Autor:
Marie-Louis Wronski, Franziska Plessow, Liya Kerem, Elisa Asanza, Michelle L. O’Donoghue, Fatima C. Stanford, Miriam A. Bredella, Martin Torriani, Alexander A. Soukas, Arvin Kheterpal, Kamryn T. Eddy, Tara M. Holmes, Thilo Deckersbach, Mark Vangel, Laura M. Holsen, Elizabeth A. Lawson
Publikováno v:
Contemporary clinical trials. 122
Obesity affects more than one-third of adults in the U.S., and effective treatment options are urgently needed. Oxytocin administration induces weight loss in animal models of obesity via effects on caloric intake, energy expenditure, and fat metabol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91803f9725c81b0b6e423c2fb3815264
https://pubmed.ncbi.nlm.nih.gov/36087842
https://pubmed.ncbi.nlm.nih.gov/36087842
Autor:
Jeramie D. Watrous, Khoi Dao, Zhaozhi Li, Sudeshna Das, Read Pukkila-Worley, Sinclair Emans, Alexander A. Soukas, Fasih M. Ahsan, Nicholas D. Peterson, Adebanjo Adedoja, Sainan Li, Lucydalila Cedillo, Mohit Jain
Biguanides, including the world’s most commonly prescribed drug for type 2 diabetes, metformin, not only lower blood sugar, but also promote longevity in preclinical models. Epidemiologic studies in humans parallel these findings, indicating favora
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::becd3043c6465d678e82982c5f657b4d
https://doi.org/10.1101/2021.09.02.457410
https://doi.org/10.1101/2021.09.02.457410
Autor:
Hans M. Dalton, Cole M. Haynes, Chia-An Yen, Sean P. Curran, Sarah M. Anderson, Nandhitha Uma Naresh, James D. Nhan, Dana L Ruter, Hilary K. Cheesman, Christian D. Turner, Read Pukkila-Worley, Alexander A. Soukas
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance The transcription factor SKN-1, the Caenorhabditis elegans ortholog of mammalian NRF2, mediates cytoprotective responses to diverse stresses to restore cellular homeostasis. We have discovered that pathogen exposure drives the rapid loss
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c780b915ab878bd73a038c77e8bcb6e
https://doi.org/10.1073/pnas.1909666116
https://doi.org/10.1073/pnas.1909666116
Autor:
Armen Yerevanian, Alexander A. Soukas
Publikováno v:
Curr Obes Rep
PURPOSE OF REVIEW: Metformin has multiple benefits for health beyond its antihyperglycemic properties. The purpose of this manuscript is to review the mechanisms that underlie metformin’s effects on obesity. RECENT FINDINGS: Metformin is first line
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f17c3999ad87aa4eeb8c8bc892ec3ee2
https://doi.org/10.1007/s13679-019-00335-3
https://doi.org/10.1007/s13679-019-00335-3