Zobrazeno 1 - 10
of 62
pro vyhledávání: '"Alexander A. Kolykhalov"'
Autor:
Peiqi Yin, Nicholas A. May, Laura Sandra Lello, Atef Fayed, M. Guston Parks, Adam M. Drobish, Sainan Wang, Meghan Andrews, Zachary Sticher, Alexander A. Kolykhalov, Michael G. Natchus, George R. Painter, Andres Merits, Margaret Kielian, Thomas E. Morrison
Publikováno v:
mBio, Vol 15, Iss 6 (2024)
ABSTRACT Chikungunya virus (CHIKV) is an enveloped, positive-sense RNA virus that has re-emerged to cause millions of human infections worldwide. In humans, acute CHIKV infection causes fever and severe muscle and joint pain. Chronic and debilitating
Externí odkaz:
https://doaj.org/article/dfff5e12899b43dd9c8db8e7247e88db
Autor:
Robert M. Cox, Josef D. Wolf, Nicole A. Lieberman, Carolin M. Lieber, Hae-Ji Kang, Zachary M. Sticher, Jeong-Joong Yoon, Meghan K. Andrews, Mugunthan Govindarajan, Rebecca E. Krueger, Elizabeth B. Sobolik, Michael G. Natchus, Andrew T. Gewirtz, Rik L. deSwart, Alexander A. Kolykhalov, Khan Hekmatyar, Kaori Sakamoto, Alexander L. Greninger, Richard K. Plemper
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Measles cases have surged pre-COVID-19 and the pandemic has aggravated the problem. Most measles-associated morbidity and mortality arises from destruction of pre-existing immune memory by measles virus (MeV), a paramyxovirus of the morbilli
Externí odkaz:
https://doaj.org/article/c318e8440b28489e92886789df7a2812
Autor:
Robert M. Cox, Carolin M. Lieber, Josef D. Wolf, Amirhossein Karimi, Nicole A. P. Lieberman, Zachary M. Sticher, Pavitra Roychoudhury, Meghan K. Andrews, Rebecca E. Krueger, Michael G. Natchus, George R. Painter, Alexander A. Kolykhalov, Alexander L. Greninger, Richard K. Plemper
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Therapeutic options against SARS-CoV-2 are underutilized. Two oral drugs, molnupiravir and paxlovid (nirmatrelvir/ritonavir), have received emergency use authorization. Initial trials suggested greater efficacy of paxlovid, but recent studie
Externí odkaz:
https://doaj.org/article/61d1e30d9f164794bdecb43d97a77a87
Autor:
Julien Sourimant, Carolin M. Lieber, Megha Aggarwal, Robert M. Cox, Josef D. Wolf, Jeong-Joong Yoon, Mart Toots, Chengin Ye, Zachary Sticher, Alexander A. Kolykhalov, Luis Martinez-Sobrido, Gregory R. Bluemling, Michael G. Natchus, George R. Painter, Richard K. Plemper
Publikováno v:
bioRxiv
Science
Science
The COVID-19 pandemic has underscored the critical need for broad-spectrum therapeutics against respiratory viruses. Respiratory syncytial virus (RSV) is a major threat to pediatric patients and the elderly. We describe 4’-fluorouridine (4’-FlU,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a9a490333684dc23dc48664090d7f06
https://pubmed.ncbi.nlm.nih.gov/34031658
https://pubmed.ncbi.nlm.nih.gov/34031658
Autor:
Robert M Cox, Carolin M Lieber, Josef D Wolf, Amirhossein Karimi, Nicole A P Lieberman, Zachary M Sticher, Pavitra Roychoudhury, Meghan K Andrews, Rebecca E Krueger, Michael G Natchus, George R Painter, Alexander A Kolykhalov, Alexander L Greninger, Richard K Plemper
Publikováno v:
bioRxiv
Despite the continued spread of SARS-CoV-2 and emergence of variants of concern (VOC) that are capable of escaping preexisting immunity, therapeutic options are underutilized. In addition to preventing severe disease in high-risk patients, antivirals
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d826bcf5816628c7ba9b71dc6797bf6
https://pubmed.ncbi.nlm.nih.gov/36451893
https://pubmed.ncbi.nlm.nih.gov/36451893
Autor:
Carolin M. Lieber, Megha Aggarwal, Jeong-Joong Yoon, Robert M. Cox, Hae-Ji Kang, Julien Sourimant, Mart Toots, Scott K. Johnson, Cheryl A. Jones, Zachary M. Sticher, Alexander A. Kolykhalov, Manohar T. Saindane, Stephen M. Tompkins, Oliver Planz, George R. Painter, Michael G. Natchus, Kaori Sakamoto, Richard K. Plemper
Influenza outbreaks are associated with substantial morbidity, mortality and economic burden. Next generation antivirals are needed to treat seasonal infections and prepare against zoonotic spillover of avian influenza viruses with pandemic potential
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06b4a0e6406c62c40e4bba51689586e8
https://doi.org/10.1101/2022.11.05.515296
https://doi.org/10.1101/2022.11.05.515296
Autor:
Gregory R. Bluemling, Shuli Mao, Michael G. Natchus, Wendy Painter, Sabue Mulangu, Mark Lockwood, Abel De La Rosa, Trevor Brasel, Jason E. Comer, Alexander N. Freiberg, Alexander A. Kolykhalov, George R. Painter
The unprecedented magnitude of the 2013-2016 Ebola virus (EBOV) epidemic in West Africa resulted in over 11,000 deaths and spurred an international public health emergency. A second outbreak in 2018-2020 in DRC resulted in an additional >3400 cases a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::54dc3248a92fa332815e96410974c759
https://doi.org/10.1101/2022.10.18.512767
https://doi.org/10.1101/2022.10.18.512767
Autor:
Gregory R, Bluemling, Shuli, Mao, Michael G, Natchus, Wendy, Painter, Sabue, Mulangu, Mark, Lockwood, Abel, De La Rosa, Trevor, Brasel, Jason E, Comer, Alexander N, Freiberg, Alexander A, Kolykhalov, George R, Painter
Publikováno v:
Antiviral research. 209
The unprecedented magnitude of the 2013-2016 Ebola virus (EBOV) epidemic in West Africa resulted in over 11 000 deaths and spurred an international public health emergency. A second outbreak in 2018-2020 in DRC resulted in an additional3400 cases and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::54c76b10578980536022477c62606374
https://pubmed.ncbi.nlm.nih.gov/36379378
https://pubmed.ncbi.nlm.nih.gov/36379378
Autor:
Benhur Lee, Robert M. Cox, Jose R. Marengo, Negar Makhsous, Mart Toots, Jeong-Joong Yoon, Richard K. Plemper, Mugunthan Govindarajan, Satoshi Ikegame, Alexander L. Greninger, Michael G. Natchus, Ruth E. Watkinson, Michelle J. Lin, Julien Sourimant, Zachary M. Sticher, Alexander A. Kolykhalov, Patricia A. Thibault
Publikováno v:
Nature microbiology
Paramyxoviruses such as human parainfluenza virus type-3 (HPIV3) and measles virus (MeV) are a substantial health threat. In a high-throughput screen for inhibitors of HPIV3 (a major cause of acute respiratory infection), we identified GHP-88309—a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f52729f7232a684354bf11b7c3674a89
https://doi.org/10.1038/s41564-020-0752-7
https://doi.org/10.1038/s41564-020-0752-7
Autor:
Gregory R. Bluemling, Shuli Mao, Michael G. Natchus, Wendy Painter, Sabue Mulangu, Mark Lockwood, Abel De La Rosa, Trevor Brasel, Jason E. Comer, Alexander N. Freiberg, Alexander A. Kolykhalov, George R. Painter
Publikováno v:
Antiviral Research. 209:105453
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c23f03f1420e913d1fd5890771076dbf
https://doi.org/10.1016/j.antiviral.2022.105453
https://doi.org/10.1016/j.antiviral.2022.105453