Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Alexander A. Karakashian"'
Autor:
Natalia V. Giltiay, Alexander A. Karakashian, Alexander P. Alimov, Sandy Ligthle, Mariana N. Nikolova-Karakashian
Publikováno v:
Journal of Lipid Research, Vol 46, Iss 11, Pp 2497-2505 (2005)
Interleukin-1β (IL-1β) is a major inducer of liver acute-phase protein expression in response to infection. Several transcription factors, including CCAAT/enhancer binding protein (C/EBP), are known mediators in this process, although the mechanism
Externí odkaz:
https://doaj.org/article/a742162ce9d84a8fa7604f4f592d24e5
Autor:
Lysa P. Posner, Mariana Nikolova-Karakashian, Alexander A. Karakashian, Sha Chang, Michael W. Nolan, Donald M. Roback, Tracy L. Gieger, Judith N. Rivera
Publikováno v:
Technology in Cancer Research & Treatment
GRID directs alternating regions of high- and low-dose radiation at tumors. A large animal model mimicking the geometries of human treatments is needed to complement existing rodent systems (eg, microbeam) and clarify the physical and biological attr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9d7347bd9d4b35881689bb616df7a84
https://doi.org/10.1177/1533034617690980
https://doi.org/10.1177/1533034617690980
Publikováno v:
Biochemical Journal. 465:371-382
Neutral sphingomyelinase-2 (nSMase-2) is the major sphingomyelinase activated in response to pro-inflammatory cytokines and during oxidative stress. It is a membrane-bound 655 amino acid protein containing 22 cysteine residues. In this study, we expr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1d5ea462a4d1b05e20370f11a96e1e0
https://doi.org/10.1042/bj20140665
https://doi.org/10.1042/bj20140665
Publikováno v:
Journal of Biological Chemistry. 287:44749-44760
FoxO1 transcription factor controls the glucose and lipid metabolism, as well as cell proliferation and stress response. Akt, activated by insulin and other growth factors, phosphorylates FoxO1 causing its nuclear export and activity suppression. In
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fd5cf4c3279fde103c0fc8ca7396ece1
https://doi.org/10.1074/jbc.m112.378836
https://doi.org/10.1074/jbc.m112.378836
Autor:
Alexander A. Karakashian, Aneta Dobierzewska, Mariana Nikolova-Karakashian, Sathish Kumar Sabapathi, Natalia V. Giltiay
Publikováno v:
Journal of Biological Chemistry. 286:32064-32073
The IL-1β signaling cascade is initiated by the phosphorylation of IL-1β receptor-associated kinase-1 (IRAK-1), followed by its ubiquitination and degradation. This paper investigates the regulation of IRAK-1 degradation in primary hepatocytes and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0244136fd373cabde745f65cea933372
https://doi.org/10.1074/jbc.m111.238030
https://doi.org/10.1074/jbc.m111.238030
Autor:
Alexander A. Karakashian, Kristina Rutkute, Natalia V. Giltiay, Mariana Nikolova-Karakashian, Aneta Dobierzewska
Publikováno v:
Hepatology. 46:1166-1176
The process of aging has recently been shown to substantially affect the ability of cells to respond to inflammatory challenges. We demonstrate that aging leads to hepatic hyperresponsiveness to interleukin 1β (IL-1β), and we examine the factors th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01bce57c5ae8c633c0f0d0adf00d2cb1
https://doi.org/10.1002/hep.21777
https://doi.org/10.1002/hep.21777
Autor:
Alexander A. Karakashian, Sabapathi Sathishkumar, Aneta Dobierzewska, L. Shi, Natalia V. Giltiay, Daipayan Banerjee, Mariana Nikolova-Karakashian
Publikováno v:
American journal of physiology. Endocrinology and metabolism. 310(8)
The level of insulin-like growth factor-binding protein 1 (IGFBP1), a liver-produced serum protein that regulates insulin-like growth factor-I bioactivity, glucose homeostasis, and tissue regeneration, increases during inflammation. This manuscript d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27f1de39180a788c4464b64595f5f7d8
https://pubmed.ncbi.nlm.nih.gov/26884383
https://pubmed.ncbi.nlm.nih.gov/26884383
Autor:
Mohammed Mohiuddin, Mahesh Kudrimoti, Krassimira A. Rozenova, Alexander A. Karakashian, Sabapathi Sathishkumar, Mansoor M. Ahmed, Natalia V. Giltiay, Boris B. Boyanovsky, Mariana Nikolova-Karakashian
Publikováno v:
Cancer Biology & Therapy. 4:979-986
Spatially fractionated high dose (grid) radiation treatment (SFGRT) involves irradiation of bulky tumors with one high, grid-delivered, dose of 15 Gy followed by multiple consecutive doses of 2 Gy each. The goal of this study is to determine the effe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3e9266d9e896dbf4d9ff37750cbbac4
https://doi.org/10.4161/cbt.4.9.1915
https://doi.org/10.4161/cbt.4.9.1915
Autor:
Alexander A. Karakashian, Natalia V. Giltiay, Kelley King, Boris B. Boyanovsky, Mariana Nikolova-Karakashian
Publikováno v:
Journal of Biological Chemistry. 278:26992-26999
Ceramide is a bioactive molecule involved in cellular responses to stress and inflammation. The major pathway for ceramide accumulation is via agonist-induced activation of cellular sphingomyelinases. It has also been shown that the ceramide level in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c690c60e0d0eecdb02ad159b25f39908
https://doi.org/10.1074/jbc.m301536200
https://doi.org/10.1074/jbc.m301536200
Publikováno v:
The Journal of biological chemistry. 287(53)
FoxO1 transcription factor controls the glucose and lipid metabolism, as well as cell proliferation and stress response. Akt, activated by insulin and other growth factors, phosphorylates FoxO1 causing its nuclear export and activity suppression. In
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2d77e9a4fa91cbba8f69d6ab3e21d87f
https://pubmed.ncbi.nlm.nih.gov/23105097
https://pubmed.ncbi.nlm.nih.gov/23105097