Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Alexander A. Henneman"'
Autor:
Marloes Zoetemelk, George M. Ramzy, Magdalena Rausch, Thibaud Koessler, Judy R. vanBeijnum, Andrea Weiss, Valentin Mieville, Sander R. Piersma, Richard R. deHaas, Céline Delucinge‐Vivier, Axel Andres, Christian Toso, Alexander A. Henneman, Simone Ragusa, Tatiana V. Petrova, Mylène Docquier, Thomas A. McKee, Connie R. Jimenez, Youssef Daali, Arjan W. Griffioen, Laura Rubbia‐Brandt, Pierre‐Yves Dietrich, Patrycja Nowak‐Sliwinska
Publikováno v:
Molecular Oncology, Vol 14, Iss 11, Pp 2894-2919 (2020)
The current standard of care for colorectal cancer (CRC) is a combination of chemotherapeutics, often supplemented with targeted biological drugs. An urgent need exists for improved drug efficacy and minimized side effects, especially at late‐stage
Externí odkaz:
https://doaj.org/article/95a558b6cae1422989a521f96cb74001
Autor:
David G. J. Cucchi, Carolien Van Alphen, Sonja Zweegman, Bo Van Kuijk, Zinia J. Kwidama, Adil al Hinai, Alexander A. Henneman, Jaco C. Knol, Sander R. Piersma, Thang V. Pham, Connie R. Jimenez, Jacqueline Cloos, Jeroen J. W. M. Janssen
Publikováno v:
HemaSphere, Vol 5, Iss 7, p e606 (2021)
Externí odkaz:
https://doaj.org/article/a219996f1c814e4b922a7f69833bb632
Autor:
Andrea Weiss, Connie R. Jimenez, Patrycja Nowak-Sliwinska, Pierre-Yves Dietrich, Alexander A. Henneman, Marloes Zoetemelk, Mylène Docquier, Youssef Daali, Thibaud Koessler, Magdalena Rausch, Céline Delucinge-Vivier, Thomas Alexander Mckee, Axel Andres, Christian Toso, Tatiana V. Petrova, Richard R. de Haas, Simone Ragusa, Sander R. Piersma, George Mourad Ramzy, Arjan W. Griffioen, Valentin Mieville, Laura Rubbia-Brandt, Judy R. van Beijnum
Publikováno v:
Molecular Oncology
Molecular oncology, vol. 14, no. 11, pp. 2894-2919
Molecular Oncology (2020)
Zoetemelk, M, Ramzy, G M, Rausch, M, Koessler, T, van Beijnum, J R, Weiss, A, Mieville, V, Piersma, S R, de Haas, R R, Delucinge-Vivier, C L, Andres, A, Toso, C, Henneman, A A, Ragusa, S, Petrova, T V, Docquier, M, McKee, T A, Jimenez, C R, Daali, Y, Griffioen, A W, Rubbia-Brandt, L, Dietrich, P-Y & Nowak-Sliwinska, P 2020, ' Optimized low-dose combinatorial drug treatment boosts selectivity and efficacy of colorectal carcinoma treatment ', Molecular oncology, vol. 14, no. 11, pp. 2894-2919 . https://doi.org/10.1002/1878-0261.12797
Molecular oncology, 14(11), 2894-2919. Elsevier
Molecular Oncology, Vol 14, Iss 11, Pp 2894-2919 (2020)
Molecular oncology, vol. 14, no. 11, pp. 2894-2919
Molecular Oncology (2020)
Zoetemelk, M, Ramzy, G M, Rausch, M, Koessler, T, van Beijnum, J R, Weiss, A, Mieville, V, Piersma, S R, de Haas, R R, Delucinge-Vivier, C L, Andres, A, Toso, C, Henneman, A A, Ragusa, S, Petrova, T V, Docquier, M, McKee, T A, Jimenez, C R, Daali, Y, Griffioen, A W, Rubbia-Brandt, L, Dietrich, P-Y & Nowak-Sliwinska, P 2020, ' Optimized low-dose combinatorial drug treatment boosts selectivity and efficacy of colorectal carcinoma treatment ', Molecular oncology, vol. 14, no. 11, pp. 2894-2919 . https://doi.org/10.1002/1878-0261.12797
Molecular oncology, 14(11), 2894-2919. Elsevier
Molecular Oncology, Vol 14, Iss 11, Pp 2894-2919 (2020)
Therapeutically guided multidrug optimization (TGMO) technology, composed of experimental testing and in silico modelling, allowed identification of synergistic and selective low‐dose optimized drug combinations (ODCs) active in multiple colorectal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::697c0adf39c6243b6ff93e1d09b7bbfb
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85092087787&origin=inward
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85092087787&origin=inward
Autor:
Alexander A. Henneman, Marloes Zoetemelk, Connie R. Jimenez, Richard R. de Haas, Judy R. van Beijnum, Louise C. Reckman, Patrycja Nowak-Sliwinska, Tse J. Wong, Arjan W. Griffioen, Olivier Dormond, Sander R. Piersma, Andrea Weiss, Axel Bex, Robert H. Berndsen
Publikováno v:
Cancers, Vol. 12, No 9 (2020) P. 2697
Cancers
Volume 12
Issue 9
van Beijnum, J R, Weiss, A, Berndsen, R H, Wong, T J, Reckman, L C, Piersma, S R, Zoetemelk, M, de Haas, R, Dormond, O, Bex, A, Henneman, A A, Jimenez, C R, Griffioen, A W & Nowak-Sliwinska, P 2020, ' Integrating phenotypic search and phosphoproteomic profiling of active kinases for optimization of drug mixtures for rcc treatment ', Cancers, vol. 12, no. 9, pp. 1-19 . https://doi.org/10.3390/cancers12092697
Cancers, 12(9), 1-19. Multidisciplinary Digital Publishing Institute (MDPI)
Cancers, vol. 12, no. 9, pp. E2697
Cancers, Vol 12, Iss 2697, p 2697 (2020)
Cancers
Volume 12
Issue 9
van Beijnum, J R, Weiss, A, Berndsen, R H, Wong, T J, Reckman, L C, Piersma, S R, Zoetemelk, M, de Haas, R, Dormond, O, Bex, A, Henneman, A A, Jimenez, C R, Griffioen, A W & Nowak-Sliwinska, P 2020, ' Integrating phenotypic search and phosphoproteomic profiling of active kinases for optimization of drug mixtures for rcc treatment ', Cancers, vol. 12, no. 9, pp. 1-19 . https://doi.org/10.3390/cancers12092697
Cancers, 12(9), 1-19. Multidisciplinary Digital Publishing Institute (MDPI)
Cancers, vol. 12, no. 9, pp. E2697
Cancers, Vol 12, Iss 2697, p 2697 (2020)
Combined application of multiple therapeutic agents presents the possibility of enhanced efficacy and reduced development of resistance. Definition of the most appropriate combination for any given disease phenotype is challenged by the vast number o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b59d8c2ac5883f40c4d86091d90b07f5
http://www.scopus.com/inward/record.url?scp=85091658861&partnerID=8YFLogxK
http://www.scopus.com/inward/record.url?scp=85091658861&partnerID=8YFLogxK
Autor:
Bart Kok, Tonny Lagerweij, Jaco C. Knol, Giulia Mantini, Geert Kazemier, T.Y.S. Le Large, Sander R. Piersma, B. El Hassouni, Maarten F. Bijlsma, Elisa Giovannetti, Alexander A. Henneman, Connie R. Jimenez, H.W.M. van Laarhoven, Luca Morelli, Niccola Funel, R. R. de Haas, Thang V. Pham
Publikováno v:
Journal of Experimental & Clinical Cancer Research : CR
le Large, T Y S, Bijlsma, M F, el Hassouni, B, Mantini, G, Lagerweij, T, Henneman, A A, Funel, N, Kok, B, Pham, T V, de Haas, R, Morelli, L, Knol, J C, Piersma, S R, Kazemier, G, van Laarhoven, H W M, Giovannetti, E & Jimenez, C R 2021, ' Focal adhesion kinase inhibition synergizes with nab-paclitaxel to target pancreatic ductal adenocarcinoma ', JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, vol. 40, no. 1, 91 . https://doi.org/10.1186/s13046-021-01892-z
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, 40(1):91. BioMed Central
Journal of Experimental & Clinical Cancer Research, Vol 40, Iss 1, Pp 1-12 (2021)
Journal of experimental & clinical cancer research, 40(1):91. BioMed Central
le Large, T Y S, Bijlsma, M F, el Hassouni, B, Mantini, G, Lagerweij, T, Henneman, A A, Funel, N, Kok, B, Pham, T V, de Haas, R, Morelli, L, Knol, J C, Piersma, S R, Kazemier, G, van Laarhoven, H W M, Giovannetti, E & Jimenez, C R 2021, ' Focal adhesion kinase inhibition synergizes with nab-paclitaxel to target pancreatic ductal adenocarcinoma ', JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, vol. 40, no. 1, 91 . https://doi.org/10.1186/s13046-021-01892-z
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, 40(1):91. BioMed Central
Journal of Experimental & Clinical Cancer Research, Vol 40, Iss 1, Pp 1-12 (2021)
Journal of experimental & clinical cancer research, 40(1):91. BioMed Central
Background Pancreatic ductal adenocarcinoma (PDAC) is a very lethal disease, with minimal therapeutic options. Aberrant tyrosine kinase activity influences tumor growth and is regulated by phosphorylation. We investigated phosphorylated kinases as ta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8214a63d52784a518e8ca3893d4ce0e7
http://www.scopus.com/inward/record.url?scp=85102552220&partnerID=8YFLogxK
http://www.scopus.com/inward/record.url?scp=85102552220&partnerID=8YFLogxK
Autor:
Tim Schelfhorst, Jaco C. Knol, Alexander A. Henneman, Sander R. Piersma, Carolien van Alphen, David G. J. Cucchi, Connie R. Jimenez, Thang V. Pham, Jeroen Janssen, Jacqueline Cloos
Publikováno v:
Journal of Proteomics, 238:104134. Elsevier
van Alphen, C, Cucchi, D G J, Cloos, J, Schelfhorst, T, Henneman, A A, Piersma, S R, Pham, T V, Knol, J C, Jimenez, C R & Janssen, J J W M 2021, ' The influence of delay in mononuclear cell isolation on acute myeloid leukemia phosphorylation profiles ', Journal of Proteomics, vol. 238, 104134 . https://doi.org/10.1016/j.jprot.2021.104134
van Alphen, C, Cucchi, D G J, Cloos, J, Schelfhorst, T, Henneman, A A, Piersma, S R, Pham, T V, Knol, J C, Jimenez, C R & Janssen, J J W M 2021, ' The influence of delay in mononuclear cell isolation on acute myeloid leukemia phosphorylation profiles ', Journal of Proteomics, vol. 238, 104134 . https://doi.org/10.1016/j.jprot.2021.104134
Mass-spectrometry (MS) based phosphoproteomics is increasingly used to explore aberrant cellular signaling and kinase driver activity, aiming to improve kinase inhibitor (KI) treatment selection in malignancies. Phosphorylation is a dynamic, highly r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df2e0474374f21a69bbd4170066c7d0b
https://pubmed.ncbi.nlm.nih.gov/33561558
https://pubmed.ncbi.nlm.nih.gov/33561558
Autor:
Sonja Zweegman, Alexander A. Henneman, Connie R. Jimenez, Adil Al Hinai, Zinia J. Kwidama, Sander R. Piersma, David G. J. Cucchi, Bo J. van Kuijk, Jaco C. Knol, Jeroen Janssen, Thang V. Pham, Carolien van Alphen, Jacqueline Cloos
Publikováno v:
HemaSphere. Wolters Kluwer Health
HemaSphere
HemaSphere, Vol 5, Iss 7, p e606 (2021)
HemaSphere, 6(7):e606. Wolters Kluwer Health
Cucchi, D G J, van Alphen, C, Zweegman, S, van Kuijk, B, Kwidama, Z J, Al Hinai, A, Henneman, A A, Knol, J C, Piersma, S R, Pham, T V, Jimenez, C R, Cloos, J & Janssen, J J W M 2021, ' Phosphoproteomic characterization of primary AML samples and relevance for response toward FLT3-inhibitors ', HemaSphere . https://doi.org/10.1097/HS9.0000000000000606
HemaSphere
HemaSphere, Vol 5, Iss 7, p e606 (2021)
HemaSphere, 6(7):e606. Wolters Kluwer Health
Cucchi, D G J, van Alphen, C, Zweegman, S, van Kuijk, B, Kwidama, Z J, Al Hinai, A, Henneman, A A, Knol, J C, Piersma, S R, Pham, T V, Jimenez, C R, Cloos, J & Janssen, J J W M 2021, ' Phosphoproteomic characterization of primary AML samples and relevance for response toward FLT3-inhibitors ', HemaSphere . https://doi.org/10.1097/HS9.0000000000000606
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf360b48998fe0847a28f815d75388a5
https://doi.org/10.1097/hs9.0000000000000606
https://doi.org/10.1097/hs9.0000000000000606