Citrullination modulates antigen processing and presentation by revealing cryptic epitopes in rheumatoid arthritis

Autor: Ashley M. Curran, Alexander A. Girgis, Yura Jang, Jonathan D. Crawford, Mekha A. Thomas, Ryan Kawalerski, Jeff Coller, Clifton O. Bingham, Chan Hyun Na, Erika Darrah

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)

Antibodies directed against citrullinated proteins are commonly found in patients with rheumatoid arthritis. Here, the authors show that citrullination alters the peptide repertoire presented to T cells by altering protease cleavage and inducing prot

Externí odkaz: https://doaj.org/article/167ebce599e34f1fa373394b0186f854

Pancreatic cancer is marked by complement-high blood monocytes and tumor-associated macrophages

Autor: Samantha B Kemp, Nina G Steele, Eileen S Carpenter, Katelyn L Donahue, Grace G Bushnell, Aaron H Morris, Stephanie The, Sophia M Orbach, Veerin R Sirihorachai, Zeribe C Nwosu, Carlos Espinoza, Fatima Lima, Kristee Brown, Alexander A Girgis, Valerie Gunchick, Yaqing Zhang, Costas A Lyssiotis, Timothy L Frankel, Filip Bednar, Arvind Rao, Vaibhav Sahai, Lonnie D Shea, Howard C Crawford, Marina Pasca di Magliano

Publikováno v: Life Science Alliance

This study uses biomaterial scaffolds to identify a macrophage gene signature defined by high expression of C1qa, C1qb, and Trem2 that is elevated systemically in mouse and human pancreatic cancer.
Pancreatic ductal adenocarcinoma (PDA) is accom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0cf90ac8412a610d0a673d6e234e680
https://pubmed.ncbi.nlm.nih.gov/33782087

Successful Use of Cangrelor and Heparin for Cardiopulmonary Bypass in a Patient With Heparin-Induced Thrombocytopenia and End-Stage Renal Disease: A Case Report

Autor: Eugene Golts, Alexander M Girgis, Doug Humber, Dalia A. Banks

Publikováno v: A&A Practice. 13:10-12

Heparin is the only well-established anticoagulant medication for cardiopulmonary bypass making selecting an alternative anticoagulant challenging in patients with heparin-induced thrombocytopenia. Other anticoagulant medications can cause significan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::99aae5893d6f70cdd9817e9058020511
https://doi.org/10.1213/xaa.0000000000000969

Immunotherapy response induces divergent tertiary lymphoid structure morphologies in hepatocellular carcinoma.

Autor: Shu DH; Marlene and Stewart Greenebaum Comprehensive Cancer Center, University of Maryland, Baltimore, MD, USA.; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Johns Hopkins University, Baltimore, MD, USA.; Convergence Institute, Johns Hopkins University, Baltimore, MD, USA., Ho WJ; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Johns Hopkins University, Baltimore, MD, USA.; Convergence Institute, Johns Hopkins University, Baltimore, MD, USA., Kagohara LT; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Johns Hopkins University, Baltimore, MD, USA.; Convergence Institute, Johns Hopkins University, Baltimore, MD, USA., Girgis A; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Johns Hopkins University, Baltimore, MD, USA.; Convergence Institute, Johns Hopkins University, Baltimore, MD, USA.; Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Johns Hopkins University, Baltimore, MD, USA., Shin SM; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Johns Hopkins University, Baltimore, MD, USA., Danilova L; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Johns Hopkins University, Baltimore, MD, USA., Lee JW; Department of Pathology, Johns Hopkins University School of Medicine, Johns Hopkins University, Baltimore, MD, USA., Sidiropoulos DN; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Johns Hopkins University, Baltimore, MD, USA.; Convergence Institute, Johns Hopkins University, Baltimore, MD, USA., Mitchell S; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Johns Hopkins University, Baltimore, MD, USA., Munjal K; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Johns Hopkins University, Baltimore, MD, USA., Howe K; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Johns Hopkins University, Baltimore, MD, USA., Bendinelli KJ; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Johns Hopkins University, Baltimore, MD, USA., Kartalia E; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Johns Hopkins University, Baltimore, MD, USA., Qi H; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Johns Hopkins University, Baltimore, MD, USA., Mo G; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Johns Hopkins University, Baltimore, MD, USA., Montagne J; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Johns Hopkins University, Baltimore, MD, USA.; Convergence Institute, Johns Hopkins University, Baltimore, MD, USA., Leatherman JM; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Johns Hopkins University, Baltimore, MD, USA., Lopez-Vidal TY; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Johns Hopkins University, Baltimore, MD, USA.; Convergence Institute, Johns Hopkins University, Baltimore, MD, USA., Zhu Q; Convergence Institute, Johns Hopkins University, Baltimore, MD, USA.; Department of Pathology, Johns Hopkins University School of Medicine, Johns Hopkins University, Baltimore, MD, USA., Huff AL; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Johns Hopkins University, Baltimore, MD, USA.; Convergence Institute, Johns Hopkins University, Baltimore, MD, USA., Yuan X; Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Johns Hopkins University, Baltimore, MD, USA., Hernandez A; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Johns Hopkins University, Baltimore, MD, USA., Coyne EM; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Johns Hopkins University, Baltimore, MD, USA., Zaidi N; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Johns Hopkins University, Baltimore, MD, USA.; Convergence Institute, Johns Hopkins University, Baltimore, MD, USA., Zabransky DJ; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Johns Hopkins University, Baltimore, MD, USA.; Convergence Institute, Johns Hopkins University, Baltimore, MD, USA., Engle LL; Department of Dermatology, Johns Hopkins University School of Medicine, Johns Hopkins University, Baltimore, MD, USA.; The Mark Foundation Center for Advanced Genomics and Imaging, Johns Hopkins University, Baltimore, MD, USA.; Bloomberg∼Kimmel Institute for Cancer Immunotherapy and Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD, USA., Ogurtsova A; Department of Dermatology, Johns Hopkins University School of Medicine, Johns Hopkins University, Baltimore, MD, USA.; The Mark Foundation Center for Advanced Genomics and Imaging, Johns Hopkins University, Baltimore, MD, USA.; Bloomberg∼Kimmel Institute for Cancer Immunotherapy and Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD, USA., Baretti M; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Johns Hopkins University, Baltimore, MD, USA., Laheru D; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Johns Hopkins University, Baltimore, MD, USA.; Convergence Institute, Johns Hopkins University, Baltimore, MD, USA., Durham JN; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Johns Hopkins University, Baltimore, MD, USA., Wang H; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Johns Hopkins University, Baltimore, MD, USA., Sunshine JC; Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Johns Hopkins University, Baltimore, MD, USA.; Department of Pathology, Johns Hopkins University School of Medicine, Johns Hopkins University, Baltimore, MD, USA.; Department of Dermatology, Johns Hopkins University School of Medicine, Johns Hopkins University, Baltimore, MD, USA.; The Mark Foundation Center for Advanced Genomics and Imaging, Johns Hopkins University, Baltimore, MD, USA.; Bloomberg∼Kimmel Institute for Cancer Immunotherapy and Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD, USA., Johnston RJ; Genentech Inc, South San Francisco, CA, USA., Deutsch JS; Department of Dermatology, Johns Hopkins University School of Medicine, Johns Hopkins University, Baltimore, MD, USA.; The Mark Foundation Center for Advanced Genomics and Imaging, Johns Hopkins University, Baltimore, MD, USA.; Bloomberg∼Kimmel Institute for Cancer Immunotherapy and Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD, USA., Taube JM; Department of Dermatology, Johns Hopkins University School of Medicine, Johns Hopkins University, Baltimore, MD, USA.; The Mark Foundation Center for Advanced Genomics and Imaging, Johns Hopkins University, Baltimore, MD, USA.; Bloomberg∼Kimmel Institute for Cancer Immunotherapy and Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD, USA., Anders RA; Convergence Institute, Johns Hopkins University, Baltimore, MD, USA.; Department of Pathology, Johns Hopkins University School of Medicine, Johns Hopkins University, Baltimore, MD, USA., Jaffee EM; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Johns Hopkins University, Baltimore, MD, USA.; Convergence Institute, Johns Hopkins University, Baltimore, MD, USA.; Bloomberg∼Kimmel Institute for Cancer Immunotherapy and Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD, USA., Fertig EJ; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Johns Hopkins University, Baltimore, MD, USA. ejfertig@jhmi.edu.; Convergence Institute, Johns Hopkins University, Baltimore, MD, USA. ejfertig@jhmi.edu.; Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Johns Hopkins University, Baltimore, MD, USA. ejfertig@jhmi.edu.; Department of Applied Mathematics and Statistics, Johns Hopkins University Whiting School of Engineering, Johns Hopkins University, Baltimore, MD, USA. ejfertig@jhmi.edu., Yarchoan M; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Johns Hopkins University, Baltimore, MD, USA. mark.yarchoan@jhmi.edu.; Convergence Institute, Johns Hopkins University, Baltimore, MD, USA. mark.yarchoan@jhmi.edu.; Bloomberg∼Kimmel Institute for Cancer Immunotherapy and Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD, USA. mark.yarchoan@jhmi.edu.

Publikováno v: Nature immunology [Nat Immunol] 2024 Nov; Vol. 25 (11), pp. 2110-2123. Date of Electronic Publication: 2024 Oct 25.

Interleukin 22 Signaling Regulates Acinar Cell Plasticity to Promote Pancreatic Tumor Development in Mice.

Autor: Perusina Lanfranca M; Department of Surgery, University of Michigan, Ann Arbor, Michigan., Zhang Y; Department of Surgery, University of Michigan, Ann Arbor, Michigan., Girgis A; Department of Surgery, University of Michigan, Ann Arbor, Michigan., Kasselman S; Department of Surgery, University of Michigan, Ann Arbor, Michigan., Lazarus J; Department of Surgery, University of Michigan, Ann Arbor, Michigan., Kryczek I; Department of Surgery, University of Michigan, Ann Arbor, Michigan; Department of Pathology, University of Michigan, Ann Arbor, Michigan., Delrosario L; Department of Surgery, University of Michigan, Ann Arbor, Michigan., Rhim A; Department of Gastroenterology, University of Texas, MD Anderson Cancer Center, Houston, Texas., Koneva L; Computational Medicine and Bioinformatics, University of Michigan Medical School, Ann Arbor, Michigan., Sartor M; Computational Medicine and Bioinformatics, University of Michigan Medical School, Ann Arbor, Michigan., Sun L; Department of Surgery, University of Michigan, Ann Arbor, Michigan., Halbrook C; Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, Michigan., Nathan H; Department of Surgery, University of Michigan, Ann Arbor, Michigan., Shi J; Department of Pathology, University of Michigan, Ann Arbor, Michigan., Crawford HC; Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, Michigan., Pasca di Magliano M; Department of Surgery, University of Michigan, Ann Arbor, Michigan; Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, Michigan; Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, Michigan; Program in Cellular and Molecular Biology, University of Michigan, Ann Arbor, Michigan; Rogel Cancer Center, University of Michigan, Ann Arbor, Michigan., Zou W; Department of Surgery, University of Michigan, Ann Arbor, Michigan; Department of Pathology, University of Michigan, Ann Arbor, Michigan; Rogel Cancer Center, University of Michigan, Ann Arbor, Michigan; Graduate Programs in Immunology and Tumor Biology, University of Michigan, Ann Arbor, Michigan., Frankel TL; Department of Surgery, University of Michigan, Ann Arbor, Michigan; Rogel Cancer Center, University of Michigan, Ann Arbor, Michigan. Electronic address: timofran@med.umich.edu.

Publikováno v: Gastroenterology [Gastroenterology] 2020 Apr; Vol. 158 (5), pp. 1417-1432.e11. Date of Electronic Publication: 2019 Dec 14.