Zobrazeno 1 - 10
of 333
pro vyhledávání: '"Alexander A Vinks"'
Publikováno v:
BMJ Open, Vol 14, Iss 3 (2024)
Introduction The only biologic therapy currently approved to treat moderate to severe Crohn’s disease in children (8 weeks and endoscopic remission (simple endoscopic severity-Crohn’s disease≤2).Ethics and dissemination ). The study protocol ha
Externí odkaz:
https://doaj.org/article/5ebc7ea38f3e4d3693b1b3581afb7b08
Autor:
Rita R Alloway, Alexander A Vinks, Tsuyoshi Fukuda, Tomoyuki Mizuno, Eileen C King, Yuanshu Zou, Wenlei Jiang, E Steve Woodle, Simon Tremblay, Jelena Klawitter, Jost Klawitter, Uwe Christians
Publikováno v:
PLoS Medicine, Vol 14, Iss 11, p e1002428 (2017)
BACKGROUND:Although the generic drug approval process has a long-term successful track record, concerns remain for approval of narrow therapeutic index generic immunosuppressants, such as tacrolimus, in transplant recipients. Several professional tra
Externí odkaz:
https://doaj.org/article/4f6b5c162ba04fa6a0243a6e6286b413
Autor:
Pornswan Ngamprasertwong, Min Dong, Jing Niu, Raja Venkatasubramanian, Alexander A Vinks, Senthilkumar Sadhasivam
Publikováno v:
PLoS ONE, Vol 11, Iss 1, p e0146563 (2016)
Measuring fetal drug concentrations is extremely difficult in humans. We conducted a study in pregnant sheep to simultaneously describe maternal and fetal concentrations of propofol, a common intravenous anesthetic agent used in humans. Compared to i
Externí odkaz:
https://doaj.org/article/6205cf444ec1450584e0ae4e0d5928e9
Autor:
Zachary L. Taylor, Lauren E. Thompson, Heather Bear, Tomoyuki Mizuno, Alexander A. Vinks, Laura B. Ramsey
Publikováno v:
Clinical and Translational Science, Vol 14, Iss 6, Pp 2267-2277 (2021)
Abstract Low‐dose methotrexate (MTX) is a first‐line therapy for the treatment of arthritis. However, there is considerable interindividual variability in MTX exposure following standard dosing. Polymorphisms in SLCO1B1 significantly effect MTX c
Externí odkaz:
https://doaj.org/article/a6b2dde967344193adb79c03c44199eb
Autor:
Chie Emoto, Trevor N. Johnson, David Hahn, Uwe Christians, Rita R. Alloway, Alexander A. Vinks, Tsuyoshi Fukuda
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 8, Iss 5, Pp 273-284 (2019)
Physiologically‐based pharmacokinetic (PBPK) modeling allows assessment of the covariates contributing to the large pharmacokinetic (PK) variability of tacrolimus; these include multiple physiological and biochemical differences among patients. A P
Externí odkaz:
https://doaj.org/article/2417614322424306a3f5384a8e116391
Publikováno v:
Therapeutic Drug Monitoring. 45:143-150
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::34bcd237a3b4f0f3e6708d9a76036f58
https://doi.org/10.1097/ftd.0000000000001078
https://doi.org/10.1097/ftd.0000000000001078
Publikováno v:
Therapeutic Drug Monitoring. 45:376-382
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eaf87cf073f77151758d6ded85c66fa3
https://doi.org/10.1097/ftd.0000000000001045
https://doi.org/10.1097/ftd.0000000000001045
Autor:
Chie Emoto, Trevor N. Johnson, Sibylle Neuhoff, David Hahn, Alexander A. Vinks, Tsuyoshi Fukuda
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 7, Iss 7, Pp 464-473 (2018)
Morphine has large pharmacokinetic variability, which is further complicated by developmental changes in neonates and small infants. The impacts of organic cation transporter 1 (OCT1) genotype and changes in blood‐flow on morphine clearance (CL) we
Externí odkaz:
https://doaj.org/article/6eba7d5d81b146268ee380e8e8eee12d
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 7, Iss 4, Pp 237-250 (2018)
Simultaneous changes in several physiological factors may contribute to the large pharmacokinetic (PK) variability of vancomycin. This study was designed to systematically characterize the effects of multiple physiological factors to the altered PK o
Externí odkaz:
https://doaj.org/article/e7cb8beb6ecf404cba0fdb2882fbf804
Autor:
Susan M. Blaney, Brenda Weigel, Helen Chen, L. Austin Doyle, Peter J. Houghton, Darcy A. Krueger, Carol A. Mercer, George Thomas, Charlotte Ahern, Joel M. Reid, Alexander A. Vinks, Lars M. Wagner, John P. Perentesis, Maryam Fouladi
Supplemental Figure 1. Graph of IMC-A12 trough serum concentrations versus time.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b985670d0034ef45eca9969c9267b7d
https://doi.org/10.1158/1078-0432.22460369
https://doi.org/10.1158/1078-0432.22460369
