Zobrazeno 1 - 10
of 617
pro vyhledávání: '"Alexander A Vinks"'
Autor:
Jamie K. Capal, David M. Ritter, David Neal Franz, Molly Griffith, Kristn Currans, Bridget Kent, E. Martina Bebin, Hope Northrup, Mary Kay Koenig, Tomoyuki Mizuno, Alexander A. Vinks, Stephanie L. Galandi, Wujuan Zhang, Kenneth D.R. Setchell, Kelly M. Kremer, Carlos M. Prada, Hansel M. Greiner, Katherine Holland‐Bouley, Paul S. Horn, Darcy A. Krueger
Publikováno v:
Annals of the Child Neurology Society, Vol 2, Iss 2, Pp 106-119 (2024)
Abstract Objective Tuberous sclerosis complex (TSC) results from overactivity of the mechanistic target of rapamycin (mTOR). Sirolimus and everolimus are mTOR inhibitors that treat most facets of TSC but are understudied in infants. We sought to unde
Externí odkaz:
https://doaj.org/article/17fb7d1309944a378a54771f3b5d9cfb
Autor:
Nicole K. Wilson, PharmD, MS, BCTXP, Simon Tremblay, PharmD, PhD, Adele R. Shields, PharmD, E. Steve Woodle, MD, Rita R. Alloway, PharmD, Alexander A. Vinks, PharmD, PhD, Bradley Miyagawa, PharmD, Tomoyuki Mizuno, PhD
Publikováno v:
Transplantation Direct, Vol 10, Iss 8, p e1677 (2024)
Externí odkaz:
https://doaj.org/article/46e0b3350bac47339923c2425099e3be
Autor:
Zachary L. Taylor, Ethan A. Poweleit, Kelli Paice, Katherine M. Somers, Kathryn Pavia, Alexander A. Vinks, Nieko Punt, Tomoyuki Mizuno, Sonya Tang Girdwood
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 12, Iss 12, Pp 1827-1845 (2023)
Abstract There has been rising interest in using model‐informed precision dosing to provide personalized medicine to patients at the bedside. This methodology utilizes population pharmacokinetic models, measured drug concentrations from individual
Externí odkaz:
https://doaj.org/article/56d8ea879ac64219a5762377a87769e5
Publikováno v:
BMJ Open, Vol 14, Iss 3 (2024)
Introduction The only biologic therapy currently approved to treat moderate to severe Crohn’s disease in children (8 weeks and endoscopic remission (simple endoscopic severity-Crohn’s disease≤2).Ethics and dissemination ). The study protocol ha
Externí odkaz:
https://doaj.org/article/5ebc7ea38f3e4d3693b1b3581afb7b08
Autor:
Matthijs W. van Hoogdalem, Ryota Tanaka, Khaled Abduljalil, Trevor N. Johnson, Scott L. Wexelblatt, Henry T. Akinbi, Alexander A. Vinks, Tomoyuki Mizuno
Publikováno v:
Pharmaceutics, Vol 16, Iss 3, p 375 (2024)
Buprenorphine readily crosses the placenta, and with greater prenatal exposure, neonatal opioid withdrawal syndrome (NOWS) likely grows more severe. Current dosing strategies can be further improved by tailoring doses to expected NOWS severity. To al
Externí odkaz:
https://doaj.org/article/f4fb827a797440a68bc781f557d22126
Autor:
Luke R. Smart, Mwesige Charles, Kathryn E. McElhinney, Min Dong, Alexandra Power-Hays, Thad Howard, Alexander A. Vinks, Emmanuela E. Ambrose, Russell E. Ware
Publikováno v:
Frontiers in Molecular Biosciences, Vol 10 (2023)
Introduction: Hydroxyurea is effective disease-modifying treatment for sickle cell anemia (SCA). Escalation to maximum tolerated dose (MTD) achieves superior benefits without additional toxicities, but requires dose adjustments with serial monitoring
Externí odkaz:
https://doaj.org/article/183e0c06437248edad0f4356a4244ac4
Autor:
Sonya Tang Girdwood, Kathryn Pavia, Kelli Paice, H. Rhodes Hambrick, Jennifer Kaplan, Alexander A. Vinks
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
There has been emerging interest in implementing therapeutic drug monitoring and model-informed precision dosing of β-lactam antibiotics in critically ill patients, including children. Despite a position paper endorsed by multiple international soci
Externí odkaz:
https://doaj.org/article/b019359bd12d49da9ed8607f8680817b
Autor:
Zachary L. Taylor, Lauren E. Thompson, Heather Bear, Tomoyuki Mizuno, Alexander A. Vinks, Laura B. Ramsey
Publikováno v:
Clinical and Translational Science, Vol 14, Iss 6, Pp 2267-2277 (2021)
Abstract Low‐dose methotrexate (MTX) is a first‐line therapy for the treatment of arthritis. However, there is considerable interindividual variability in MTX exposure following standard dosing. Polymorphisms in SLCO1B1 significantly effect MTX c
Externí odkaz:
https://doaj.org/article/a6b2dde967344193adb79c03c44199eb
Autor:
Emily R. Meier, Susan E. Creary, Matthew M. Heeney, Min Dong, Abena O. Appiah-Kubi, Stephen C. Nelson, Omar Niss, Connie Piccone, Maa-Ohui Quarmyne, Charles T. Quinn, Kay L. Saving, John P. Scott, Ravi Talati, Teresa S. Latham, Amanda Pfeiffer, Lisa M. Shook, Alexander A. Vinks, Adam Lane, Patrick T. McGann
Publikováno v:
Trials, Vol 21, Iss 1, Pp 1-14 (2020)
Abstract Background Sickle cell disease (SCD) is a severe and devastating hematological disorder that affects over 100,000 persons in the USA and millions worldwide. Hydroxyurea is the primary disease-modifying therapy for the SCD, with proven benefi
Externí odkaz:
https://doaj.org/article/f4848c1e5cb84d1ca9d6331a034404f0
Autor:
Chie Emoto, Trevor N. Johnson, David Hahn, Uwe Christians, Rita R. Alloway, Alexander A. Vinks, Tsuyoshi Fukuda
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 8, Iss 5, Pp 273-284 (2019)
Physiologically‐based pharmacokinetic (PBPK) modeling allows assessment of the covariates contributing to the large pharmacokinetic (PK) variability of tacrolimus; these include multiple physiological and biochemical differences among patients. A P
Externí odkaz:
https://doaj.org/article/2417614322424306a3f5384a8e116391